Self-organization of hydroxyapatite nanorods through oriented attachment

Chen, Jing Di; Wang, Ying Jun; Wei, Kun; Zhang, Shu Hua; Shi, Xuetao

doi:10.1016/j.biomaterials.2007.01.033

Cited by 176 publications

(101 citation statements)

References 25 publications

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“…However the apatite deposited on the chitosan scaffolds was different from that suspended in solution. From the previous reports, HAP tends to form one dimensional nanowires or sea-urchin aggre- gates consisting of nanorods or nanowires in aqueous solution [24][25][26]. Here, the interesting point is the different morphologies of HAP formed in solution and on chitosan scaffolds walls.…”

Section: Determination Of Phase Composition Withmentioning

confidence: 82%

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

Li¹,

Zhao²,

Ding³

et al. 2011

Express Polym. Lett.

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Abstract. Biomimetic mineralization was performed on a large scale by a rapid and efficient approach. Chitosan scaffolds were placed in a mixed solution of urea, ethanol and distilled water, followed by the introduction of dibasic sodium phosphate (0.1M) and calcium chloride (0.1M) with the molar ratio of 1.67. These mixed solvents was then adjusted to weakly alkaline by adding sodium hydroxide solution. Finally the reaction mixture was sealed and kept at 80ºC for predetermined time. The composition and morphology of the apatite and the hybrid scaffolds were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier Transform Infrared spectroscopy (FTIR) and environmental scanning electron microscopy (ESEM). The mechanism of nucleation and growth of crystals was discussed as well. The results revealed that chitosan scaffolds improved the crystallinity of hydroxyapatite (HAP) crystals. With the extension of mineralization time, the mineral layers on the outer surface and inner section of chitosan scaffolds increased as well. Furthermore, the compressive strength and modulus of the HAP-chitosan scaffolds biocomposites increased to 0.55±0.003 and 29.29±1.25 MPa respectively. Such one-pot approach may be extended to the mineralization of other materials and will have a broad application in the future.

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Section: Determination Of Phase Composition Withmentioning

confidence: 82%

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

Li¹,

Zhao²,

Ding³

et al. 2011

Express Polym. Lett.

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show abstract

“…7 (c, d, g, h) exhibited the selected area electron diffraction SAED which corresponding to different planes such as (002) planes for hexagonal HA [32]. This indicates that pure HA and HA in the nanocomposites grows along the c-axis direction into uniform rod like shape.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 94%

The Effect of Different Solvents for Chitosan Solubilization on The Crystal Growth of in situ Prepared Hydroxyapatite

2017

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C HITOSAN/hydroxyapatite (CS/HA) nanocomposites have been widely fabricated for potential use in bone defects due to their high biocompatibility and similarity to the natural bone. In the current study, HA nanocrystals were prepared by co-precipitation method in CS which was initially dissolved in different concentrations of acrylic acid and acetic acid (2 and 4 %). The effect of chitosan solvents on the morphology of HA nanocrystals, the crystallite sizes, and the physical binding with CS were investigated by different techniques including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscope (TEM). The FT-IR and XPS results showed that the interaction between CS and HA in the nanocomposites is predominantly dependent on the type of solvent used to dissolve CS. When acetic acid was used, the interaction between CS and HA was stronger when compared to acrylic acid. Quantitative XPS results showed that the atomic percentage of nitrogen (N1s) of the amine groups of CS was less in the case of the composites prepared after dissolving CS in acrylic acid compared to acetic acid. The amine groups of CS (−NH 2 ) can start the nucleation of HA crystals and remain bounded to the surface of the grown crystal through chelation with calcium ions on the crystal facets. In both organic solvents, HA crystals were found to grow along their c-axis direction into rodshape but the growth in the width was more restricted in case of acetic acid. The results in the current study indicated that the type of CS solvents is determining the strength of the physical interaction between the CS and HA. This might be a crucial factor to control and enhance the mechanical and the biological behaviors of the nanocomposites.

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“…2,19,20,44 Due to the complete decomposition of urea at relatively elevated temperatures, urea can only affect the characteristics of HAp in the former stage. The complex urea-Ca 2+ prevents the Ca 2+ ions from reacting quickly with the other reactants and this, therefore, decreases the number of nucleation sites.…”

Section: Mean Diameter Of Hap Nanoparticlesmentioning

confidence: 99%

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

Sadat‐Shojai¹,

Atai²,

Nodehi³

2011

J. Braz. Chem. Soc.

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O objetivo deste trabalho foi investigar a influência de diversos parâmetros de reação sobre as propriedades de nanopartículas de hidroxiapatita (HAp) preparadas pelo método hidrotérmico. Os dados da literatura descrevem condições experimentais variadas para a síntese hidrotérmica de HAp. Uma abordagem específica foi então utilizada para avaliar os fatores estatisticamente influentes entre aqueles descritos na literatura. O papel de cada parâmetro experimental também foi discutido no contexto da nucleação de partículas e do mecanismo de crescimento de cristais. Dentro das variáveis selecionadas, temperatura e pH foram os fatores que mais afetaram a composição e morfologia da HAp. Além disso, neste estudo, diferentes morfologias variando de nanopartículas cilíndricas do tipo bastonete a esféricas com várias características foram obtidas com sucesso, o que pode ser aplicável na preparação de várias biocerâmicas de HAp.The aim of this work was to investigate the influence of different reaction parameters on the properties of hydroxyapatite (HAp) nanoparticles prepared by the hydrothermal method. The literature data describe widely different experimental conditions for the hydrothermal synthesis of HAp. A specific approach was therefore used to evaluate the statistically influential factors among those described in the literature. The role of each experimental parameter was also discussed within the framework of particle nucleation and crystal growth mechanism. Among the selected variables, temperature and pH were found to be the most significant factors affecting the composition and morphology of the HAp. Moreover, in the present study, different morphologies ranging from rod-like to spherical nanoparticles with various characteristics were successfully obtained, which can be applicable for the preparation of various HAp bioceramics.

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Self-organization of hydroxyapatite nanorods through oriented attachment

Cited by 176 publications

References 25 publications

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

Rapid biomimetic mineralization of chitosan scaffolds with a precursor sacrificed method in ethanol/water mixed solution

The Effect of Different Solvents for Chitosan Solubilization on The Crystal Growth of in situ Prepared Hydroxyapatite

Design of experiments (DOE) for the optimization of hydrothermal synthesis of hydroxyapatite nanoparticles

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