2023
DOI: 10.1101/2023.04.04.534476
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Self-organized intracellular twisters

Abstract: Life in complex systems, such as cities and organisms, comes to a standstill when global coordination of mass, energy, and information flows is disrupted. Global coordination is no less important in single cells, especially in large oocytes and newly formed embryos, which commonly use fast fluid flows for dynamic reorganization of their cytoplasm. Here, we combine theory, computing, and imaging to investigate such flows in the Drosophila oocyte, where streaming has been proposed to spontaneously arise from hyd… Show more

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Cited by 2 publications
(2 citation statements)
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“…As microtubules elongate and encounter the cell periphery, they push on the centrosomal aster, potentially leading to microtubule buckling [46]. Computational tools such as Cytosim [47] and SkellySim [48,49] have been employed to simulate these phenomena, accommodating extensive microtubule deformations and in the case of SkellySim, incorporating hydrodynamic interactions due to microtubule motion. Various coarse-grained models have also been constructed to account for microtubule pushing forces, assuming microtubules grow briefly against the cell surface and push, but disassemble before buckling [7,12,15,50].…”
Section: Discussionmentioning
confidence: 99%
“…As microtubules elongate and encounter the cell periphery, they push on the centrosomal aster, potentially leading to microtubule buckling [46]. Computational tools such as Cytosim [47] and SkellySim [48,49] have been employed to simulate these phenomena, accommodating extensive microtubule deformations and in the case of SkellySim, incorporating hydrodynamic interactions due to microtubule motion. Various coarse-grained models have also been constructed to account for microtubule pushing forces, assuming microtubules grow briefly against the cell surface and push, but disassemble before buckling [7,12,15,50].…”
Section: Discussionmentioning
confidence: 99%
“…On one hand, filament-like polymers are categorized as semiflexible and forced by tangential propulsion by molecular motors or self-propulsion of the monomers, leading to hydrodynamic interactions with their ambient fluids and the emergence of large-scale coherent flows. 16–23 On the other hand, biopolymers like chromatin have lengths significantly surpassing their persistence lengths and are effectively modeled as flexible polymers. While understanding the multi-scale behavior of chromatin requires consideration of inter-bead interactions, and evaluating chromosomal structure at nucleosome resolution necessitates accounting for bending rigidity, 24–28 flexible polymer models consistently capture the meso-scale dynamics 29–33 and can accommodate environmental viscoelasticity, 30,34,35 architectural looping, 32,36 and hydrodynamics.…”
Section: Introductionmentioning
confidence: 99%