Self-oscillating gel as novel biomimetic materials

Yoshida, Ryo; Sakai, Takamasa; Hara, Yusuke; Maeda, Shingo; Hashimoto, Shuji; Suzuki, Daisuke; Murase, Yoko

doi:10.1016/j.jconrel.2009.04.029

Cited by 63 publications

(41 citation statements)

References 44 publications

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“…These attributes could be usefully exploited in a range of microfluidic applications, where, for example, an external light source could be utilized to tailor the movement of a soft ''conveyor belt'' 78,79,93 and thus, regulate the transport of microscopic objects within the devices.…”

Section: Probing the Behavior Of Two Interacting Ciliamentioning

confidence: 99%

Chemo-responsive, self-oscillating gels that undergo biomimetic communication

et al. 2013

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Species ranging from single-cell organisms to social insects can undergo auto-chemotaxis, where the entities move towards a chemo-attractant that they themselves emit. Polymer gels undergoing the self-oscillating Belousov-Zhabotinsky (BZ) reaction exhibit autonomous, periodic pulsations, which produce chemical species collectively referred to as the activator. The diffusion of this activator into the surrounding solution affects the dynamic behavior of neighboring BZ gels and hence, the BZ gels not only emit, but also respond to self-generated chemical gradients. This review describes recent experimental and computational studies that reveal how this biomimetic behavior effectively allows neighboring BZ gels to undergo cooperative, self-propelled motion. These distinctive properties of the BZ gels provide a route for creating reconfigurable materials that autonomously communicate with neighboring units and thereby actively participate in constructing the desired structures.

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Section: Probing the Behavior Of Two Interacting Ciliamentioning

confidence: 99%

Chemo-responsive, self-oscillating gels that undergo biomimetic communication

et al. 2013

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“…The uniqueness of smart polymers lies not only in the rapid macroscopic changes occurring in their structure but also in the reversible nature of these transitions. The affected factors include shape [9], surface characteristics [10,11], solubility [12], molecular affinity [13,14], and sol-gel transition [15], etc., whereas the external triggers can be temperature [2,5,16], pH [4,17], ionic strength [18], or certain chemicals [19,20]. More recently, electric fields [21], magnetic fields [22], and light [23] have been used as additional stimuli for these polymers.…”

Section: Introductionmentioning

confidence: 99%

A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

Techawanitchai

Idota

Uto

et al. 2012

Science and Technology of Advanced Materials

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We demonstrate a timed explosive drug release from smart pH-responsive hydrogels by utilizing a phototriggered spatial pH-jump reaction. A photoinitiated proton-releasing reaction of o-nitrobenzaldehyde (o-NBA) was integrated into poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (P(NIPAAm-co-CIPAAm)) hydrogels. o-NBA-hydrogels demonstrated the rapid release of protons upon UV irradiation, allowing the pH inside the gel to decrease to below the pK a value of P(NIPAAm-co-CIPAAm). The generated protons diffused gradually toward the non-illuminated area, and the diffusion kinetics could be controlled by adjusting the UV irradiation time and intensity. After irradiation, we observed the enhanced release of entrapped L-3,4-dihydroxyphenylalanine (DOPA) from the gels, which was driven by the dissociation of DOPA from CIPAAm. Local UV irradiation also triggered the release of DOPA from the non-illuminated area in the gel via the diffusion of protons. Conventional systems can activate only the illuminated region, and their response is discontinuous when the light is turned off. The ability of the proposed pH-jump system to permit gradual activation via proton diffusion may be beneficial for the design of predictive and programmable devices for drug delivery.

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“…Since the first report in 1996, [7] we have been systematically studying polymer and gel systems as novel biomimetic materials. [8][9][10][11][12][13][14][15] The design of polymers for biomedical applications has also been investigated.…”

Section: Introductionmentioning

confidence: 99%

Self‐Driven Gel Conveyer: Effect of Interactions Between Loaded Cargo and Self‐Oscillating Gel Surface

Murase¹,

Takeshima²,

Yoshida³

2011

Macromolecular Bioscience

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A "self-oscillating" gel that swells and deswells periodically under constant conditions is developed as a novel biomimetic gel differing from conventional stimuli-responsive polymer gels. By utilizing the peristaltic motion of the self-oscillating gel, autonomous mass-transport systems can be realized. With the propagation of the chemical wave, the loaded gel cargo is autonomously transported by rotating on the surface. To apply the self-driven gel conveyer to a wider range of uses, it is important to investigate the influence of the physical interaction between the self-oscillating gel and the loaded cargo on its transporting ability. Here, the effect of the interaction is evaluated by using several kinds of gel cargo with varying charge states, hydrophilicities, and surface roughnesses.

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Self-oscillating gel as novel biomimetic materials

Cited by 63 publications

References 44 publications

Chemo-responsive, self-oscillating gels that undergo biomimetic communication

Chemo-responsive, self-oscillating gels that undergo biomimetic communication

A smart hydrogel-based time bomb triggers drug release mediated by pH-jump reaction

Self‐Driven Gel Conveyer: Effect of Interactions Between Loaded Cargo and Self‐Oscillating Gel Surface

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