The increase in deportations over the years has had adverse effects on immigrant families, communities, and countries of origin. Involuntary return, especially deportation, causes economic hardship, emotional distress, and family separation. Given the rising number of deportees in Africa and Ghana in particular, this study sought to explore the challenges that confront deportees in re-integrating into the Nkoranza Municipality of Ghana. Using a qualitative research design, 20 participants (19 males and 1 female) were purposively recruited for the study. In-depth interviews (IDIs) were conducted to gather data, which were analyzed thematically. The findings of the study indicated that many of the deportees faced challenges, such as difficulty in accessing jobs, food and attendant health complications, and loss of personal belongings. Other challenges were negative perceptions and poor relationships, as well as inaccessible formal support services. Based on the findings of the study, implications are discussed.