Self-powered and photothermal electronic skin patches for accelerating wound healing

Du, Shuo; Suo, Huinan; Xie, Ge; Lyu, Quanqian; Mo, Min; Xie, Zhixiao; Zhou, Nan; Zhang, Lianbin; Tao, Juan; Zhu, Jintao

doi:10.1016/j.nanoen.2021.106906

Cited by 94 publications

(88 citation statements)

References 38 publications

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“…Du et al used polypyrrole with photothermal properties combined with Pluronic F127 to make a photothermal hydrogel. [ 115 ] Due to the electrical conductivity of polypyrrole and the excellent deformability of F127, this hydrogel was used as an electronic skin patch. Electrical stimulation and photothermal heating jointly stimulate angiogenesis and collagen deposition at the wound site, which effectively promotes wound healing.…”

Section: Hydrogel Combined With Photothermal Therapymentioning

confidence: 99%

Hydrogel Combined with Phototherapy in Wound Healing

Chen

Ying

et al. 2022

Adv Healthcare Materials

110

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Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound healing, and do not have high antibacterial properties. Hydrogels, which are capable of retaining large amounts of water, can create a moist healing environment. Currently, phototherapies have exhibited a high potential for the treatment of bacterial infections. Therefore, combining hydrogels with phototherapy can adequately overcome the shortcomings of traditional wound treatment methods and show great potential for wound healing owing to their high efficiency, low irritation, and good antibacterial performance. In this review, the application of hydrogels combined with phototherapy in wound healing is summarized. First, the basic principles of photodynamic therapy and photothermal therapy are briefly introduced. In addition, the progress of the application of hydrogel combined with phototherapy in wound healing is systematically investigated. Finally, the challenges and prospects of combining hydrogel with phototherapy in wound healing are discussed.

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Section: Hydrogel Combined With Photothermal Therapymentioning

confidence: 99%

Hydrogel Combined with Phototherapy in Wound Healing

Chen

Ying

et al. 2022

Adv Healthcare Materials

110

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“…between wound surface and TENG patch, developed to harvest biomechanical energy and deliver electrical stimulation to injured tissue [87] . Some other similar examples include a flexible, stretchable sandwich structured triboelectric patch composed of double-layer polydimethylsiloxane (PDMS) membrane with a PAAm-LiCl hydrogel embedded [88] and genetically engineered recombinant spider silk proteins based TENG patch [89] . To improve upon the TENG concept of wound healing as described above, a singleelectrode TENG-based e-skin patch for promoting wound healing by synergistically utilizing electrical stimulation and photothermal heating capability, with conductive and photothermal polypyrrole/Pluronic F127 hydrogels as electrolytes [90] was developed, and the whole concept is shown in Figure 11D.…”

Section: Wearable Electrical Stimulatorsmentioning

confidence: 99%

Wearable electronics for skin wound monitoring and healing

Patel¹,

Ershad²,

Zhao³

et al. 2022

Soft Sci

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Wound healing is one of the most complex processes in the human body, supported by many cellular events that are tightly coordinated to repair the wound efficiently. Chronic wounds have potentially life-threatening consequences. Traditional wound dressings come in direct contact with wounds to help them heal and avoid further complications. However, traditional wound dressings have some limitations. These dressings do not provide real-time information on wound conditions, leading clinicians to miss the best time for adjusting treatment. Moreover, the current diagnosis of wounds is relatively subjective. Wearable electronics have become a unique platform to potentially monitor wound conditions in a continuous manner accurately and even to serve as accelerated healing vehicles. In this review, we briefly discuss the wound status with some objective parameters/biomarkers influencing wound healing, followed by the presentation of various novel wearable devices used for monitoring wounds and accelerating wound healing. We further summarize the associated device working principles. This review concludes by highlighting some major challenges in wearable devices toward wound healing that need to be addressed by the research community.

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“…Stretchable and/or shape adaptable 41 [53,79,126,130,158, Ultrathin d) 5 [183,190,205,210,213] Transparent 9 [130,158,182,187,194,196,203,206,213] Sweat permeable 1 [213] Wireless connected 5 [208,[214][215][216][217] Low-cost 11 [179,183,188,190,191,198,199,204,211,214,218] Facile manufacturing 6 [179,183,184,188,199,214] Biocompatible 4 [53,79,190,213] Metal-free 1 [219] Humidity resistive 2 [181,220] Self-healable 5…”

Section: Hmimentioning

confidence: 99%

“…A recent article from Du and coworkers demonstrated a TENG-based ENG that can promote wound recovery by using both electrical stimulation and photothermal heating. [53] The device was fabricated by filling polypyrrole (PPy)/F127 composite into a cured Ecoflex groove. The authors noted that this structure Figure 12.…”

Section: Wound Healingmentioning

confidence: 99%

A Review on Epidermal Nanogenerators: Recent Progress of the Future Self‐Powered Skins

Nguyen

Cheng

2022

Small Structures

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Epidermal nanogenerators (ENGs), defined as nano‐enabled, thin, soft, and flexible skin‐like devices that can convert mechanical and thermal energy into electricity, are emerging as a promising self‐powered technology for wearable biomedical devices. This review covers the discussion of working mechanisms, design strategy, and major requirements of the state‐of‐the‐art ENGs including piezoelectric, triboelectric, pyroelectric, and hybrid. In addition, their representative applications in human–machine interface (HMI), wound healing, and wearable biomedical sensors are described. In particular, a focus has been on the narration of self‐powered ENG‐based biosensors for detecting physical, biochemical, and physiological signals. Despite the encouraging advances over the past decade, the field of ENGs remains in the early stage of development with limited real‐world adoption. There remain a number of challenges such as insufficient energy and power density for powering wearable devices, poor air permeability, limited washability, and durability under severe conditions. The future opportunity lies at the development of better materials and/or designs to tackle these challenges to generate real‐world impact.

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Self-powered and photothermal electronic skin patches for accelerating wound healing

Cited by 94 publications

References 38 publications

Hydrogel Combined with Phototherapy in Wound Healing

Hydrogel Combined with Phototherapy in Wound Healing

Wearable electronics for skin wound monitoring and healing

A Review on Epidermal Nanogenerators: Recent Progress of the Future Self‐Powered Skins

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