Self‐Powered Controllable Transdermal Drug Delivery System

Yang, Yuan; Xu, Lingling; Jiang, Dongjie; Chen, Bo Zhi; Luo, Ruizeng; Liu, Zhuo; Qu, Xuecheng; Wang, Chan; Shan, Yizhu; Cui, Yong; Zheng, Hui; Wang, Zhiwei; Wang, Zhong Lin; Guo, Xin Dong; Zhou, Li

doi:10.1002/adfm.202104092

Cited by 77 publications

(49 citation statements)

References 41 publications

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“…The morphology of the microneedles was present in Figure 3 c obtained by an optical microscope and Figure 3 d acquired by a scanning electron microscope (SEM). The stiffness of the PLA microneedles had already been tested by the animal experiment [ 40 ]. From the finite element analysis, when the applied voltage was 600 V, the EF of microneedle electrode was above 3 kV/cm ( Figure 3 e).…”

Section: Resultsmentioning

confidence: 99%

Self-Powered Electrical Impulse Chemotherapy for Oral Squamous Cell Carcinoma

et al. 2022

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Oral squamous cell carcinoma (OSCC) is a common oral cancer of the head and neck, which causes tremendous physical and mental pain to people. Traditional chemotherapy usually results in drug resistance and side effects, affecting the therapy process. In this study, a self-powered electrical impulse chemotherapy (EIC) method based on a portable triboelectric nanogenerator (TENG) was established for OSCC therapy. A common chemotherapeutic drug, doxorubicin (DOX), was used in the experiment. The TENG designed with zigzag structure had a small size of 6 cm × 6 cm, which could controllably generate the fixed output of 200 V, 400 V and 600 V. The electrical impulses generated by the TENG increased the cell endocytosis of DOX remarkably. Besides, a simply and ingeniously designed microneedle electrode increased the intensity of electric field (EF) between two adjacent microneedle tips compared with the most used planar interdigital electrode at the same height, which was more suitable for three-dimensional (3D) cells or tissues. Based on the TENG, microneedle electrode and DOX, the self-powered EIC system demonstrated a maximal apoptotic cell ratio of 22.47% and a minimum relative 3D multicellular tumor sphere (MCTS) volume of 160% with the drug dosage of 1 μg mL−1.

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Section: Resultsmentioning

confidence: 99%

Self-Powered Electrical Impulse Chemotherapy for Oral Squamous Cell Carcinoma

et al. 2022

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“…To overcome the above issue, Yang and team developed a self-powered electro-responsive MN patch for on-demand transdermal delivery of dexamethasone (Dex) to treat psoriasis . In this MN system, the piezoelectric nanogenerator (PENG) is adopted as a source of electric current.…”

Section: Stimuli-responsive Microneedlesmentioning

confidence: 99%

Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy

et al. 2022

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Microneedles are one of the most prominent approaches capable of physically disrupting the stratum corneum without devastating the deeper tissues to deliver both small molecules and macromolecules into the viable epidermis/dermis for local/systemic effects. Over the past two decades, microneedles have caught the attention of many researchers because of their outstanding advantages over oral and parenteral drug delivery systems such as self-administration, pain-free, steady-plasma concentration maintenance, avoidance of first-pass hepatic biotransformation, and so on. So far, scientists have reported various types of microneedle patches to deliver the loaded therapeutics as soon as the microneedles are inserted into the skin, regardless of the demand for therapeutics to treat a specific condition. This way of drug delivery can lead to potential risks such as poor therapeutic efficacy or drug overdose. The stimuliresponsive microneedles are the most predominant tool to achieve the on-demand/need-based drug delivery, leading to safe and effective treatment. Various natural and synthetic polymers that can undergo significant transitions such as swelling, shrinking, dissolution, or disintegration play a pivotal role in the development of stimuli-responsive microneedles. The current Review provides brief information about the history, emergence, type, and working principles of microneedles. Furthermore, it selectively discusses various exogenous and endogenous stimuli-responsive microneedles along with their mechanism of action involved in treating different disease conditions. Collaterally, the emergence of "closed-loop" combinatorial stimuli-responsive microneedle patches for precise delivery of therapeutics is meticulously canvassed. Subsequently, it covers the patents of different stimuli-responsive microneedles and further highlights the existing challenges and future perspectives concerning clinical application and large-scale production.

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“…Extensive research over the past decades provided ample proof of the potential of MN-based technology for medical therapy and diagnosis in a convenient and minimally invasive manner. 63–66 The studies summarized in this review show the feasibility of the MN-based technology for cell delivery or cell sampling due to its innate advantages of pain-free mechanical disruption of the tissue barriers, better tissue compatibility, selective lesions targeting, and enhanced therapeutic efficacy with a reduction in dose and side effects. Compared to conventional cell injections or clinical implantation, the MN-based cell therapy can control the delivery of the therapeutic cells to the targeted sites with minimal tissue damage and is more suitable for self-administration by patients.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%