Self‐Propelled Tags for Protein Detection

Mayorga‐Martinez, Carmen C.; Pumera, Martin

doi:10.1002/adfm.201906449

Cited by 45 publications

(37 citation statements)

References 55 publications

(72 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therein, the functionalization of m‐bots is crucial for diagnostics, isolation, and biosensing applications. [ 225,323–327 ] Based on the donor–receptor interactions, m‐bots can capture, transport, and release biomacromolecules and cells for isolation purposes. [ 328–332 ] Concanavalin A lectin shows strong coupling effect with polysaccharides.…”

Section: Biomedical Applications Of M‐botsmentioning

confidence: 99%

Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

et al. 2020

View full text Add to dashboard Cite

Micro‐/nanorobots (m‐bots) have attracted significant interest due to their suitability for applications in biomedical engineering and environmental remediation. Particularly, their applications in in vivo diagnosis and intervention have been the focus of extensive research in recent years with various clinical imaging techniques being applied for localization and tracking. The successful integration of well‐designed m‐bots with surface functionalization, remote actuation systems, and imaging techniques becomes the crucial step toward biomedical applications, especially for the in vivo uses. This review thus addresses four different aspects of biomedical m‐bots: design/fabrication, functionalization, actuation, and localization. The biomedical applications of the m‐bots in diagnosis, sensing, microsurgery, targeted drug/cell delivery, thrombus ablation, and wound healing are reviewed from these viewpoints. The developed biomedical m‐bot systems are comprehensively compared and evaluated based on their characteristics. The current challenges and the directions of future research in this field are summarized.

show abstract

Section: Biomedical Applications Of M‐botsmentioning

confidence: 99%

Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Micro/nanorobots are small-scale artificial machines that rationally designed to perform predefined tasks by converting various energies into mechanical motion and various chemical triggers to perform the designed action [1] , [2] , [3] , [4] , [5] . Along with their advanced performances, such as autonomous self-propelling, precisely maneuverable speed and direction, and remote actuation, these tiny robotic systems have demonstrated great potential for a wide range of applications, including sensing [6] , [7] , [8] , targeted delivery [ 2 , 5 ], microsurgery [ 9 , 10 ], biofilm disruption [ 11 , 12 ], and environmental remediation [ 13 , 14 ]. In particular, micro/nanorobots have been exploited to enhance the analytical performance in biosensing applications [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Plasmonic-magnetic nanorobots for SARS-CoV-2 RNA detection through electronic readout

Kim

Mayorga‐Martinez

Vyskočil

et al. 2022

Applied Materials Today

Self Cite

View full text Add to dashboard Cite

The coronavirus disease 2019 (COVID‐19) has prompted an urgent demand for nanotechnological solutions towards the global healthcare crisis, particularly in the field of diagnostics, vaccines, and therapeutics. As an emerging tool for nanoscience and technology, micro/nanorobots have demonstrated advanced performances, such as self-propelling, precise maneuverability, and remote actuation, thus hold great potential to provide breakthroughs in the COVID-19 pandemic. Here we show a plasmonic-magnetic nanorobot-based simple and efficient COVID-19 detection assay through an electronic readout signal. The nanorobots consist of Fe 3 O 4 backbone and the outer surface of Ag, that rationally designed to perform magnetic-powered propulsion and navigation, concomitantly the probe nucleic acids transport and release upon the hybridization which can be quantified with the differential pulse voltammetry (DPV) technique. The magnetically actuated nanorobots swarming enables enhanced micromixing and active targeting, thereby promoting binding kinetics. Experimental results verified the enhanced sensing efficiency, with nanomolar detection limit and high selectivity. Further testing with extracted SARS-CoV-2 viral RNA samples validated the clinical applicability of the proposed assay. This strategy is versatile to extend targeting various nucleic acids, thus it could be a promising detection tool for other emerging infectious diseases, environmental toxins, and forensic analytes.

show abstract

“…[ 5,6 ] Compared with their static counterparts, motile nano/micromotors powered by chemical fuels. [ 7–10 ] or external sources (e.g., magnetic field, [ 11–13 ] ultrasound wave, [ 14 ] and light [ 15 ] ) exhibit notably higher working efficiency for wastewater treatment due to the vigorous dynamic stirring via performing “chemistry‐on‐the‐fly.” [ 16 ] Although many researchers have confirmed the potential of microrobots for water purification in terms of removal, or degradation of heavy metals, [ 11,17 ] oil, [ 18,19 ] antibiotics, [ 20 ] organic contamination (e.g., biological and chemical warfare agents, [ 21–23 ] nerve agents, [ 24 ] explosives, [ 13,25–27 ] dye, [ 28–31 ] pesticides), sensing, [ 32 ] and microbial contamination, [ 33–36 ] investigations on exploiting nano/microrobots for the effective removal of microplastics are still rare.…”

Section: Introductionmentioning

confidence: 99%

Microplastic Removal and Degradation by Mussel‐Inspired Adhesive Magnetic/Enzymatic Microrobots

2021

Self Cite

View full text Add to dashboard Cite

Ubiquitous pollution by microplastics is causing significant deleterious effects on marine life and human health through the food chain and has become a big challenge for the global ecosystem. It is of great urgency to find a cost‐efficient and biocompatible material to remove microplastics from the environment. Mimicking basic characteristics of the adhesive chemistry practiced by marine mussels, adhesive polydopamine (PDA)@Fe3O4 magnetic microrobots (MagRobots) are prepared by coating Fe3O4 nanoparticles with a polymeric layer of dopamine via one‐step self‐polymerization. In addition, lipase is loaded on the PDA@Fe3O4 MagRobots’ surface to perform microplastic enzymatic degradation. The synthesized MagRobots, which are externally triggered by transversal rotating magnetic field, have the capacity to clear away the targeted microplastics due to their strong sticky characteristics. With the adhesive PDA@Fe3O4 MagRobots on their surfaces, the microplastics can be navigated along an arbitrarily predefined path by a rotating field and removed using a directional magnetic field. Such adhesive MagRobots are envisioned to be used in swarms to remove microplastics from aqueous environments.

show abstract

Self‐Propelled Tags for Protein Detection

Cited by 45 publications

References 55 publications

Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

Trends in Micro‐/Nanorobotics: Materials Development, Actuation, Localization, and System Integration for Biomedical Applications

Plasmonic-magnetic nanorobots for SARS-CoV-2 RNA detection through electronic readout

Microplastic Removal and Degradation by Mussel‐Inspired Adhesive Magnetic/Enzymatic Microrobots

Contact Info

Product

Resources

About