Self-protection of Pseudomonas syringae pv. "tabaci" from its toxin, tabtoxinine-beta-lactam

Knight, Thomas J.; Durbin, R. D.; Langston-Unkefer, Pat J.

doi:10.1128/jb.169.5.1954-1959.1987

Cited by 24 publications

(3 citation statements)

References 20 publications

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“…Tabtoxin is a dipeptide containing tabtoxinine-b-lactam linked to threonine (or serine) from which proteolysis releases tabtoxinine-b-lactam that irreversibly inactivates glutamine synthase. Although adenylylation of that enzyme in the producer reduced its sensitivity to tabtoxinine-b-lactam, self-protection was attributed primarily to b-lactamase activity [100]. Thus, the ring-opened, inactive species, tabtoxinine, accumulated when Ps.…”

Section: Tabtoxinmentioning

confidence: 99%

Avoidance of suicide in antibiotic-producing microbes

Cundliffe

Demain

2010

J Ind Microbiol Biotechnol

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Many microbes synthesize potentially autotoxic antibiotics, mainly as secondary metabolites, against which they need to protect themselves. This is done in various ways, ranging from target-based strategies (i.e. modification of normal drug receptors or de novo synthesis of the latter in drug-resistant form) to the adoption of metabolic shielding and/or efflux strategies that prevent drug-target interactions. These self-defence mechanisms have been studied most intensively in antibiotic-producing prokaryotes, of which the most prolific are the actinomycetes. Only a few documented examples pertain to lower eukaryotes while higher organisms have hardly been addressed in this context. Thus, many plant alkaloids, variously described as herbivore repellents or nitrogen excretion devices, are truly antibiotics-even if toxic to humans. As just one example, bulbs of Narcissus spp. (including the King Alfred daffodil) accumulate narciclasine that binds to the larger subunit of the eukaryotic ribosome and inhibits peptide bond formation. However, ribosomes in the Amaryllidaceae have not been tested for possible resistance to narciclasine and other alkaloids. Clearly, the prevalence of suicide avoidance is likely to extend well beyond the remit of the present article.

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Section: Tabtoxinmentioning

confidence: 99%

Avoidance of suicide in antibiotic-producing microbes

Cundliffe

Demain

2010

J Ind Microbiol Biotechnol

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“…63C). 656,657 Recently, a tabtoxin-resistance gene (ttr) has been characterised 658 and used to enable the NPR Review development of transgenic tobacco cultivars resistant to P. syringae. 659 TTR is an acetyltransferase and contains the four motifs conserved in the GNAT superfamily (Section 5.10).…”

Section: Tabtoxin Biosynthesismentioning

confidence: 99%

The enzymes of β-lactam biosynthesis

et al. 2013

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The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. The desire for more efficient routes to existing antibiotics and for access to new and synthetically challenging ones stimulates continued interest in β-lactam biosynthesis. We review knowledge of the pathways leading to β-lactam antibiotics focusing on the mechanisms, structures and biocatalytic applications of the enzymes involved.

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“…1991). However, Rhizobium meliloti in the root nodules produces B‐lactamase and inactivates Pseudomonas syringae toxin (Knight et al. 1987).…”

Section: Importance Of Rhizosphere Modificationsmentioning

confidence: 99%

Ecophysiology of the Plant–Rhizosphere System

El-Shatnawi

Makhadmeh

2001

J Agronomy Crop Science

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The rhizosphere is the site of organic deposition and the generator of habitat and resource heterogeneity for soil organisms. Plants can modify their rhizosphere through nutrient, moisture and O2 uptake from the rhizosphere, rhizo‐deposition and production of root exudates. As a result, rhizosphere chemical (pH, nutrient solubility, O2, CO2 and other chemicals), physical (moisture and aeration), and biological (soil pathogens, beneficial microorganisms and allelopathy) characteristics will be changed or modified. Rhizosphere microorganisms have positive or negative effects on plant growth and morphology by affecting the plant hormone balance, plant enzymatic activity, nutrient availability and toxicity, and competition with other plants. Plants modify the rhizosphere and as a result will modify the community.

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Self-protection of Pseudomonas syringae pv. "tabaci" from its toxin, tabtoxinine-beta-lactam

Cited by 24 publications

References 20 publications

Avoidance of suicide in antibiotic-producing microbes

Avoidance of suicide in antibiotic-producing microbes

The enzymes of β-lactam biosynthesis

Ecophysiology of the Plant–Rhizosphere System

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