BACKGROUND: COVID-19 has a terrible impact worldwide, and more than 0.8 million people had died of it before September 2020. Many countries had taken many measures to against it, and one of the most effective methods was "stay-at-home" order. But staying at home for a long time is not good for human beings with social features, and that may lead to the occurrence of psychological diseases. Because of COVID-19, many people were forced to stay at home and spend more time with family members. As a special group of population, Chinese college student are more dependent on families, and their psychology, such as anxiety, may be more affected by family during the outbreak of COVID-19.METHODS: This cross-sectional study was conducted online from March 14, 2020 to March 21, 2020.The State-Trait Anxiety Inventory (ST-AI) and Chinese Family Function Scale (FAD-18) were used in this study. ANOVA was used in basic information. Path analysis was used to estimate the relationship among family function, state anxiety and trait anxiety.RESULTS: A total of 1039 respondents (695 females and 344 males) were included in the study. Their state anxiety scores were 39.28 and 36.84, respectively. The trait anxiety scores were 40.66 and 38.36, respectively. There were significant differences (p<0.01). But compared with the healthy norm, there was no significant difference. Except gender, there were significant differences (p<0.01) in state anxiety and trait anxiety between college students of medicine and art majors. In path analysis, the standard direct effect of family function on trait anxiety was 0.434(p< 0.001) in male group, 0.271(p< 0.001) in female group. While the standard direct and indirect effect of family function on state anxiety were not significant.CONCLUSIONS: This study found that during the outbreak of COVID-19, the state anxiety and trait anxiety of Chinese college students were related to gender and major. What’s more, family function had a great influence on anxiety. It is very important to pay attention to health function of family and psychological counseling for different genders and majors.