2024
DOI: 10.1101/2024.03.24.586443
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Self-quenched fluorophore-DNA labels for super-resolution fluorescence microscopy

Laurell Kessler,
Ashwin Balakrishnan,
Tanja Menche
et al.

Abstract: Protein labeling through transient and repetitive hybridization of short, fluorophore-labeled DNA oligonucleotides has become widely applied in various optical super-resolution microscopy methods. The main advantages are multi-target imaging and molecular quantification. A challenge is the high background signal originating from the presence of unbound fluorophore-DNA labels in solution. Here, we report self-quenching of fluorophore dimers conjugated to DNA oligonucleotides as a general concept to reduce the f… Show more

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