Self-quenching polysaccharide-based nanogels of pullulan/folate-photosensitizer conjugates for photodynamic therapy

Bae, Byoung-chan; Na, Kun

doi:10.1016/j.biomaterials.2010.04.030

Cited by 169 publications

(113 citation statements)

References 27 publications

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“…584 was internalized via folate receptors and the PS cleaved by intracellular enzymes or extracellular matrix producing an active PS. Fluorescence was detected 30 minutes after injection and increased over 12 h period thus exhibiting similar phototoxic properties as the free pheophorbide a [295] .…”

Section: Hydroporphyrinsmentioning

confidence: 88%

“…25 [294] . In addition a similar polysaccharide nanogel was synthesized containing pullulan/folate conjugated to Pheophorbide a PSs [295] . Pullulan is a maltotriose isolated from the fungus Aureobasidium pullulans and can be used as a drug carrier and, combined via DCC or DMAP-mediated ester formation with folate which can target overexpressed receptors on the surface of several human cancer cells, provides a selforganized nanogel.…”

Section: Formula 12mentioning

confidence: 99%

“…Pullulan is a maltotriose isolated from the fungus Aureobasidium pullulans and can be used as a drug carrier and, combined via DCC or DMAP-mediated ester formation with folate which can target overexpressed receptors on the surface of several human cancer cells, provides a selforganized nanogel. When coupled with pheophorbide a again with a carbodiimide reaction they afford nanostructures ~170 nm in size with three derivatives isolated with varying degrees of PS attached to the sugar chain [295] . One such example is 585a, a sapphyrin derivative, which exhibited a singlet oxygen quantum yield of 0.18 and showed phototoxicity against Staphylococcus aureus similar to that of HpD.…”

Section: Formula 12mentioning

confidence: 99%

“…In vivo study was carried out to determine if the ester cleavage of 583 to produce the free PS Pheophorbide a observed in vitro occurred in non-tumor-bearing Balb/Cnude mice [295] . It was demonstrated that the initial release of Pheophorbide a was slow but over time increased with the maximum achieved after 12 h incubation in agreement with the in vitro study.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…The retention of 583 was greater than for Pheophorbide a alone its presence was still observed 30 days after injection. The quantum yield of singlet oxygen was maintained at 0.43 for 30 days with irradiation at 1, 7 and 30 days carried out [295] . A glucosylated zinc phthalocyanine 613 was investigated for its potential as a near-infrared imaging agent with liver tumor-bearing athymic nude mice.…”

Section: In Vivo Studiesmentioning

confidence: 99%

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Chemical Synthesis and Medicinal Applications of Glycoporphyrins

Moylan¹,

Scanlan²,

Senge

2015

CMC

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Abstract:This review presents an in-depth overview of the modification of porphyrins with bioconjugates and their applications in medicine today. Porphyrin bioconjugates ranging from nucleotides to steroids are under active scrutiny. However, carbohydrates have been at the forefront of such research in recent years and offer significant potential. This is attributed to their own selectivity to lectins on the surface of cancer cells and their influence on the amphiphilicity of the porphyrin macrocycle. These characteristics and the tendency of porphyrin photosensitizers to accumulate in tumor tissues make glycoporphyrins promising candidates for use as photosensitizers. Thus, a detailed overview of the synthesis and biological evaluation of glycoporphyrins is given with a particular focus on their applications in photodynamic therapy and their future prospects as drug candidates have been reported.

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Section: Hydroporphyrinsmentioning

confidence: 88%

Section: Formula 12mentioning

confidence: 99%

Section: Formula 12mentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

Section: In Vivo Studiesmentioning

confidence: 99%

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Chemical Synthesis and Medicinal Applications of Glycoporphyrins

Moylan¹,

Scanlan²,

Senge

2015

CMC

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Pullulan: Properties, Synthesis, and Applications

LeDuy

Choplin

Zajic

et al. 2014

Encyclopedia of Polymer Science and Technology

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Pullulan is a water‐soluble extracellular polysaccharide, which consists of linear chains of d ‐glucopyranosyl units that alternate regularly between one (1→6)‐α‐ d and two (1→4)‐α‐ d linkages, or alternatively a linear polymer of maltotriosyl units connected by (1→6)‐α‐ d linkages. Bauer in 1938 was the first to observe the polysaccharide produced by the Aureobasidium pullulans fungus. This article reviews the physical, chemical, and biochemical properties of pullulan. Practical aspects such as laboratory‐ and industrial‐scale production as well as food, industry, and medical applications of pullulans and their derivatives are also discussed.

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