Self-Reactive T Cell Receptor-Reactive CD8+ T Cells Inhibit T Cell Lymphoma Growth In Vivo

Gonthier, Marie; Llobera, Régine; Arnaud, Jacques; Rubin, Bent

doi:10.4049/jimmunol.173.11.7062

Cited by 8 publications

(19 citation statements)

References 39 publications

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“…The general mechanisms for tumour suppression have been principally attributed to CD4 + T helper lymphocytes. Cytokines and lymphokines from CD4 + T cells can also activate CD8 + CTL, NK cells and macrophages, which have all been shown to be involved in tumour immunity [13][14][15][16][17]. Additionally, regulatory T cells (CD4 + CD25 + ) have suppressive effects on the development of tumourassociated antigen-reactive lymphocytes [18].…”

Section: Reactive Microenvironment and Non-hodgkin's Lymphoma: Differmentioning

confidence: 97%

Appraisal of immune response in lymphoproliferative syndromes: A systematic review

Álvaro¹,

Lejeune²,

Escrivá³

et al. 2009

Critical Reviews in Oncology/Hematology

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Section: Reactive Microenvironment and Non-hodgkin's Lymphoma: Differmentioning

confidence: 97%

Appraisal of immune response in lymphoproliferative syndromes: A systematic review

Álvaro¹,

Lejeune²,

Escrivá³

et al. 2009

Critical Reviews in Oncology/Hematology

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“…CD8 T cells capable of lysing tumor cells produce high amounts of TNF, suggesting that T cell-derived TNF is important for antitumor immunity in mice [66][67][68]. PrevostBlondel et al [69] used a lung carcinoma cell transfer model, where CD8 T cells induce a protective tumor-specific response and found that tumor was not rejected when carcinoma cells were inoculated to TNF -/-hosts.…”

Section: Tnf and T Cells In Immunitymentioning

confidence: 99%

“…It is of particular notice that in most cases, mTNF on T cells, rather than soluble, was proposed to mediate tumor killing/rejection [66,67,70,71].…”

Section: Tnf and T Cells In Immunitymentioning

confidence: 99%

T Cells as Sources and Targets of TNF: Implications for Immunity and Autoimmunity

Chatzidakis

Mamalaki

2010

Current Directions in Autoimmunity

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TNF is a pleiotropic cytokine produced by many cell types upon different stimuli and in various physiological and pathological conditions. In this review, we focus on the role of TNF in T cell responses as demonstrated by in vitro and in vivo observations in mice and humans. TNF has an impact on all aspects of T cell biology such as development in the thymus, peripheral homeostasis, primary antigenic responses, apoptosis, effector functions, memory cell formation and tolerance induction and maintenance. In most cases, TNF has an immunostimulatory role in T cell responses; however, under certain conditions, TNF can exert immunomodulatory effects on T cells. We also review how T cell-derived TNF is an important component of T cell immunity as exemplified by many studies involving intracellular pathogens and tumors. Finally, we summarize how TNF T cells interplay contributes to pathology in autoimmune disorders and what is known about the effect of widely used TNF blockers on T cell differentiation/function.

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“…It is even more difficult to decide on what item to concentrate. I have worked on T‐lymphocyte biology during my entire career, from T‐lymphocyte reactivity and specificity [1, 2] via structures and biosynthesis of T‐cell receptors (TCR) [3–5] to T‐lymphocyte and TCR involvement in tumour immunology and autoimmunity [6, 7]. I have decided to review my work on immune responses to tumour cells as the ideas behind this work saw the light of day and matured during my post‐doctoral years in the Institute of Tumor Biology directed by George Klein (1971–73).…”

Section: Prefacementioning

confidence: 99%

Natural Immunity has Significant Impact on Immune Responses Against Cancer

Rubin

2009

Scand J Immunol

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The immune system defends the host against pathogenic attacks by micro‐organisms and their products. It does not react against self‐components due to the relatively efficient negative selection of developing T lymphocytes in the thymus. This process does permit T cells with low avidity against self to be present in the T cell repertoire. Such cells play an important physiological role as the host needs so‐called autoimmune reactions in order to eliminate dying cells or transformed tumour cells. One of the mysteries in immunology is how the host maintains beneficial autoimmune reactions and avoids pathogenic autoimmune reactions. Activation of the adaptive T lymphocytes is mediated by the low avidity interaction between T‐cell antigen receptors and antigenic peptides associated with major histocompatibility complex class I or class II molecules. This interaction is strengthened by T‐cell co‐receptors such as CD2, CD4, CD8, CD28 and CD154, which react with ligands expressed by cells of the innate immune system. In recent years, the importance of pre‐activation of the innate immune system for initiation of adaptive T‐cell immune responses has been appreciated. In the present review, I will summarize our work on how natural immunity plays an important role in determining the level of beneficial autoimmune reactions against cancer.

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Self-Reactive T Cell Receptor-Reactive CD8+ T Cells Inhibit T Cell Lymphoma Growth In Vivo

Cited by 8 publications

References 39 publications

Appraisal of immune response in lymphoproliferative syndromes: A systematic review

Appraisal of immune response in lymphoproliferative syndromes: A systematic review

T Cells as Sources and Targets of TNF: Implications for Immunity and Autoimmunity

Natural Immunity has Significant Impact on Immune Responses Against Cancer

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