The relationships and differences between curiosity and interest have received considerable attention and discussions. Yet, most of the discussions so far draw from little direct empirical evidence. In this set of three studies, the relationship between curiosity and interest were examined. The first study was a meta-analysis that examined the Pearson correlations between scales that aimed to assess curiosity and those that aimed to assess interest. Based on 24 studies (31 effect sizes), we found that curiosity scales correlate with interest scales at a moderate level (r = .53), but have extremely high heterogeneity, suggesting that the relationship largely depends on how they are conceptualized. The second and third studies applied network analyses (i.e., co-occurrence analysis and correlation-based analysis) to data collected using experience sampling method, examining how the subjective feelings of curiosity and interest are related. Across two studies, we found consistently differences between the feelings associated with curiosity and those associated with interest. While the feeling of curiosity was closer to feelings of inquisitiveness and eagerness to know more, the feeling of interest was closer to positive affects such as enjoyment and happiness. Most importantly, an asymmetrical pattern was found in curiosity-interest co-occurrences: when the feeling of curiosity occurred, the co-occurrences of the feeling of interest were highly likely, but not vice versa. That is, when the feeling of interest occurred, the feeling of curiosity was less likely to co-occur. The theoretical and practical implications of our findings are discussed.