Self-Report of Drinking Compared to Objective Markers of Alcohol Consumption

Whitford, Jennifer L.; Widner, Sabina; Mellick, Davis; Elkins, Ralph L.

doi:10.1080/00952990802295212

Cited by 48 publications

(35 citation statements)

References 27 publications

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“…First, due to stigmatization and other adverse outcomes, self-report of smoking and drinking in high risk populations is often unreliable (Burgess et al, 2009; Caraballo et al, 2001; Erim et al, 2007; Russell et al, 2004; Whitford et al, 2009). Second, even if studies utilize biochemical verification of substance use status, current biological measures are known to have limited sensitivity (Florescu et al, 2009; Tavakoli et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation

Dogan

Lei

Beach

et al. 2016

Psychoneuroendocrinology

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Alcohol and cigarette consumption have profound effects on genome wide DNA methylation and are common, often cryptic, comorbid features of many psychiatric disorders. This cryptic consumption is a possible impediment to understanding the biology of certain psychiatric disorders because if the effects of substance use are not taken into account, their presence may confound efforts to identify effects of other behavioral disorders. Since the hypothalamic pituitary adrenal (HPA) axis is known to be dysregulated in these disorders, we examined the potential for confounding effects of alcohol and cigarette consumption by examining their effects on peripheral DNA methylation at two key HPA axis genes, NR3C1 and FKBP5. We found that the influence of alcohol and smoke exposure is more prominent at the FKBP5 gene than the NR3C1 gene. Furthermore, in both genes, loci that were consistently significantly associated with smoking and alcohol consumption demethylated with increasing exposure. We conclude that epigenetic studies of complex disorders involving the HPA axis need to carefully control for the effects of substance use in order to minimize the possibility of type I and type II errors.

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Section: Introductionmentioning

confidence: 99%

Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation

Dogan

Lei

Beach

et al. 2016

Psychoneuroendocrinology

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“…Although %CDT, a form of the serum iron carrying protein transferrin with altered carbohydrate composition, is a more specific marker for identifying chronic excessive alcohol use and monitoring abstinence, it does not have the desired sensitivity and specificity (Golka, K., et al 2004). Substantial efforts have been made to construct interview formats that correctly identify those with alcohol use disorder, such as AUDIT-C (Hawkins, E. J., et al 2010), CAGE (Skogen, J. C., et al 2011), or reports from collateral family who interact with the subject (Whitford, J. L., et al 2009). Limitations of this approach are most apparent in cases where individuals are motivated to deny or minimize the magnitude of drinking behavior to mitigate personal ramifications (Freeman, W. M. & Vrana, K. E. 2010).…”

Section: Introductionmentioning

confidence: 99%

Novel Serum Biomarkers for Detection of Excessive Alcohol Use

Liangpunsakul

Lai

Ross

et al. 2015

Alcohol Clin Exp Res

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Objectives Construct interview that correctly identifies those with alcohol use disorder have limitation, especially when the subjects are motivated to minimize the magnitude of drinking behavior. Current laboratory tests to detect excessive alcohol consumption are limited by marginal sensitivity/specificity. Excessive drinking has been shown to affect several organ systems; which may be reflected in changes in quantity of plasma proteins. Our aim was to employ novel proteomic analyses to identify potential markers for excessive alcohol use. METHODS A prospective case-control study that included 39 controls and 54 excessive drinkers (discovery cohort). The serum proteomic analyses in these subjects were performed and the results were tested in the verification cohort (40 controls and 40 excessive drinkers). RESULTS Using the appropriate cutoff and confirmation with ELISA, we identified 4 proteins which were significantly elevated in the serum of excessive drinkers; AT-rich interactive domain-containing protein 4B (ARID4B), Phosphatidylcholine-sterol acyltransferase (LCAT), Hepatocyte growth factor-like protein (MST1), and ADP-ribosylation factor 6 (ARL6). The performance of the conventional markers (AST, ALT, GGT, %CDT, and MCV) discriminating between excessive alcohol use and controls had an area under the curve (AUC) ranging from 0.21 (ALT) to 0.67 (MCV). The AUC of these novel proteins showed the improvement in the detection of excessive drinkers compared to conventional lab tests, ranging from 0.73 (for ARID4B) to 0.86 (for ARL6). CONCLUSIONS We have identified four novel proteins that can discern subjects with excessive alcohol use. Further studies are needed to determine the clinical implications of these markers to detect excessive alcohol use and confirm abstinence.

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“…Of those who enter and complete treatment, approximately 60% will relapse to some drinking within the first year following alcohol treatment (Maisto et al, 2003; Whitford et al, 2009). With these findings in mind, current research on the outcomes of alcohol-use-disorder treatments examines mechanisms of change associated with reduced alcohol use (Longabaugh et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

The effect of drinking goals at treatment entry on longitudinal alcohol use patterns among adults with alcohol dependence

Mowbray

Krentzman

Bradley

et al. 2013

Drug and Alcohol Dependence

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BACKGROUND Drinking goals at treatment entry are a promising, yet under-studied mechanism of change in alcohol use following treatment. It is not known who, upon treatment entry, is likely to desire abstinence as a drinking goal and whether desiring abstinence as a drinking goal influences alcohol use following treatment. Methods Data from a 2.5-year longitudinal study of alcohol-dependent adults from 3 treatment sites is examined in a secondary data analysis. At treatment entry, participants reported sociodemographic and clinical characteristics, as well as whether they desired abstinence as a drinking goal or not. At each subsequent wave, participants reported their alcohol use. Results Bivariate analyses showed that individuals from a VA outpatient treatment site, men, and racial or ethnic minorities were most likely to desire abstinence as a drinking goal at treatment entry. Multi-level mixed effects regression models indicated that individuals who at baseline desired abstinence as a drinking goal sustained higher percentage of days abstinent and higher percentage of days since last drink 2.5 years following treatment entry, compared to individuals who did not desire abstinence. Conclusions Understanding who is most likely to desire the specific drinking goal of abstinence can assist clinicians in anticipating client response to goal setting. Furthermore, by understanding the benefits and risks associated with drinking goals, clinicians can focus attention to individuals who desire a more risk-laden goal, including goals of non-abstinence, and tailor interventions, including motivational interviewing techniques, to support effective goals.

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Self-Report of Drinking Compared to Objective Markers of Alcohol Consumption

Abstract: Collateral informants serve an important function in supporting the validity of self-report of abstinence versus relapse.

Cited by 48 publications

References 27 publications

Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation

Alcohol and tobacco consumption alter hypothalamic pituitary adrenal axis DNA methylation

Novel Serum Biomarkers for Detection of Excessive Alcohol Use

The effect of drinking goals at treatment entry on longitudinal alcohol use patterns among adults with alcohol dependence

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