“…Dreno et al [4] also found a risk of poor adherence of 60% among patients taking a combination of both systemic and topical therapy, and a higher likelihood of poor adherence to the systemic arm of treatment compared to the topical arm (54 vs. 44%, respectively). Other studies utilizing questionnaires and/or single questions to assess adherence have found rates of poor adherence ranging from 76 to 0% [2,3,5,15,16,17]. Studies using objective measures such as not keeping appointments, pill counts, weighing medication, number of medication refills, and electronic caps have reported adherence rates ranging from 28 to 88.3% [6,7,8,18].…”