Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Tadesse, Wondmagegn Tamiru; Mekonnen, Alemayehu; Tesfaye, Wubshet; Tadesse, Yidnekachew Tamiru

doi:10.1186/2050-6511-15-32

Cited by 45 publications

(40 citation statements)

References 20 publications

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“…Clearly, the issue of the relationship between occurrence of adverse drug events and HAART modification is an extremely important one that deserves further concerted study across several countries and with a larger number of patients, especially considering the fact that HIV has now become a chronic condition, with patients likely to be on life-long therapy. In addition, the proportion of patients experiencing an adverse drug event before therapy modification in this study is similar to the proportions found in studies by Padua et al in Brazil [ 35 ] and Tadesse et al in Ethiopia [ 37 ], which indicated that 56.1 and 53.8 %, respectively, of patients who modified to another therapy self-reported at least one adverse drug reaction [ 35 , 37 ]. A similar case–control study in Ethiopia, however, showed that as high as 85.7 % of patients on HAART had changed therapy [ 32 ].…”

Section: Discussionsupporting

confidence: 89%

Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients

et al. 2016

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IntroductionPatients initiated on highly active antiretroviral therapy (HAART) generally remain on medication indefinitely. A modification in the HAART regimen may become necessary because of possible acute or chronic toxicities, concomitant clinical conditions, development of virological failure or the advent of adverse drug events. The study documents adverse drug events of HIV-positive Ghanaian patients with HAART modifications. It also investigates the association between documented adverse drug events and HAART modification using an unmatched case–control study design.MethodThe study was conducted in the Fevers Unit of the Korle Bu Teaching Hospital and involved patients who attended the HIV Care Clinic between January 2004 and December 2009. Data from 298 modified therapy patients (cases) were compared with 298 continuing therapy patients (controls) who had been on treatment for at least 1 month before the end of study. Controls were sampled from the same database of a cohort of HIV-positive patients on HAART, at the time a case occurred, in terms of treatment initiation ±1 month. Data were obtained from patients’ clinical folders and the HIV clinic database linked to the pharmacy database. The nature of the documented adverse drug events of the cases was described and the association between the documented adverse drug events and HAART modification was determined by logistic regression with reported odds ratios (ORs) and their 95 % confidence interval (CI).ResultsAmong the 298 modified therapy patients sampled in this study, 52.7 % of them had at least one documented adverse drug event. The most documented adverse drug event was anaemia, recorded in 18.5 % of modified therapy patients, all of whom were on a zidovudine-based regimen. The presence of documented adverse drug events was significantly associated with HAART modification [adjusted OR = 2.71 (95 % CI 2.11–3.48), p < 0.001].ConclusionAmong HIV patients on HAART, adverse drug events play a major role in treatment modification. Occurrence of adverse drug events may be used as a predictor for possible therapy modification. We recommend the institution of active pharmacovigilance in HIV treatment programmes as it permits the proper identification and characterisation of drug-related adverse events. This can help develop approaches towards their management and also justify therapy modifications.

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Section: Discussionsupporting

confidence: 89%

Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients

et al. 2016

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“…In this study 62% of the patients experienced side effects since they started using ARVs. These findings compare well with the findings of Tadesse et al (2014) that 89.8% of the study participants experienced at least one adverse drug reaction. A study by Masenyetse et al (2015) established that 37% of the patients on Highly active antiretroviral drugs experienced adverse drug reactions.…”

Section: Side Effects Experienced By Hiv Positive Patients On Haartsupporting

confidence: 90%

Prevalence and Factors Associated With Herbal Medicine Use among HIV Positive Patients on Highly Active Antiretroviral Therapy in Selected Hospitals in Nairobi County

2019

JBAH

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Background: Traditional remedies have been used for many years in Africa to treat various ailments before the introduction of conventional medicines into the continent. Concurrent use of traditional herbal medicines (THM) with highly active antiretroviral therapy (HAART) is widespread among HIV infected patients. Studies done in different parts of the world show conflicting health outcomes among HIV positive patients using HAART and herbal medicine concurrently with some reporting better health outcomes while others report increased risk of adverse drug reactions. However, the extent of THM use is not known in most settings in Sub-Saharan Africa Kenya included. This study aimed to determine the prevalence and factors associated with THM use among HIV infected patients on highly active antiretroviral therapy (HAART) attending two comprehensive care centers in Nairobi County. Methods: A descriptive cross-sectional study was conducted at Kenyatta National Teaching and Referral Hospital and Mbagathi District Hospital. From the two centers a total of 370 participants were selected via systematic random sampling. The participants included were those aged 18 years and above, on HAART, and had consented to participate in the study. Data was collected using an interviewer-administered semi-structured questionnaire seeking information on herbal medicine use, socio-demographic and economic factors associated with herbal medicine use and the association between herbal medicine use and occurrence of adverse drug reactions. THM use referred to someone who had ever used or was currently using herbal medicine while on highly active antiretroviral therapy (HAART) by the time of the study. Data was captured in excel sheet and exported to STATA for analysis. Results: The study established that the prevalence of herbal medicine use among HIV positive patients taking HAART was 15.5%. About 77.8% of the patients who had used herbal medicine had never disclosed to the doctor or any health care worker at the CCC about their herbal medicine use. Herbal medicine use led to decreased adherence to HAART. The longer the duration between HIV diagnosis and HAART start, the more likely a HIV positive patient was to use herbal medicine. Patients who use herbal medicine with HAART were more likely to experience adverse drug reactions. There were 59.7% participants who had good /fair adherence while 40.3% had poor adherence. Majority of those who had poor adherence had significantly higher proportion of side effects as compared to those had good/fair adherence. Conclusion: The prevalence of THM use among participants on HAART was high. This raises clinical and pharmacological concerns that need attention by the health care service providers.

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“…To our knowledge, only a few retrospective studies have attempted to identify the type and frequency of ADRs in Ethiopian adult patients receiving ART [10,11], and given the poor documentation of ADRs in patients' medical charts, ADRs are underreported. In addition, the impact of ADRs on treatment outcomes (body mass index [BMI] and CD4 count) has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study From Ethiopia

et al. 2015

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Self-reported adverse drug reactions and their influence on highly active antiretroviral therapy in HIV infected patients: a cross sectional study

Cited by 45 publications

References 20 publications

Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients

Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients

Prevalence and Factors Associated With Herbal Medicine Use among HIV Positive Patients on Highly Active Antiretroviral Therapy in Selected Hospitals in Nairobi County

Adverse Drug Reactions and Clinical Outcomes in Patients Initiated on Antiretroviral Therapy: A Prospective Cohort Study From Ethiopia

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