Self-Reported Adverse Drug Reactions, Medication Adherence, and Clinical Outcomes among Major Depressive Disorder Patients in Ethiopia: A Prospective Hospital Based Study

Abstract

Background There is paucity of data on prevalence of Adverse Drug Reactions (ADRs) and adherence and clinical outcomes of antidepressants. The present study determined the magnitude of ADRs of antidepressants and their impact on the level of adherence and clinical outcome. Methods A prospective cross-sectional study was conducted among depression patients from September 2016 to January 2017 at Gondar University Hospital psychiatry clinic. The Naranjo ADR probability scale was employed to assess the ADRs. The rate of medication adherence was determined using Morisky Medication Adherence Measurement Scale-Eight. Results Two hundred seventeen patients participated in the study, more than half of them being males (122; 56.2%). More than one-half of the subjects had low adherence to their medications (124; 57.1%) and about 186 (85.7%) of the patients encountered ADR. The most common ADR was weight gain (29; 13.2%). More than one-half (125; 57.6%) of the respondents showed improved clinical outcome. Optimal level of medication adherence decreased the likelihood of poor clinical outcome by 56.8%. Conclusion ADRs were more prevalent. However, adherence to medications was very poor in the setup. Long duration of depression negatively affects the rate of adherence. In addition, adherence was found to influence the clinical outcome of depression patients.

Self-Reported Antidepressant Drug Side Effects, Medication Adherence, and Its Associated Factors among Patients Diagnosed with Depression at the Psychiatric Hospital of Nepal

“…The study showed that the majority of patients with depression had a low level of adherence (52.29%) towards antidepressant medications. This finding showed consistency with two other studies conducted in Ethiopia and Saudi Arabia, both of which ascertained lower adherence to antidepressant medications, i.e., 52.29% and 57.1%, respectively [ 10 , 24 ]. In this study, females were found more likely to be nonadherent than males with AOR: 1.001 (0.31-1.63).…”

“…Medication adherence was found to be significantly associated with the probability and severity of antidepressant drug adverse effects/side effects at a “ P ” value of 0.05. This contradicts the finding of the Ethiopian study [ 10 ]. In this study, illiterate patients were observed to be more nonadherent than literate patients.…”

“…This study found that side effects are most common in depressive patients, as above 70% of the patients experienced antidepressant drug side effects. This finding was comparably higher than that of an Indian study (26.87%) [ 20 ] and lower than that of an Ethiopian study (85.7%) [ 10 ]. A total of 15 side effect types were identified in this study, where general ones such as insomnia, anxiety, dry mouth, and weight gain were more common among the study population.…”

“…In a study from the United States, it was reported that the patients with bothersome side effects are more likely to nonadhere to their antidepressant medications [ 9 ]. This affects the efficacy of antidepressant medications [ 10 ]. Moreover, antidepressant drug side effects are the significant determinants of antidepressant-associated nonadherence, which is predicted to be considerably high among depressive people [ 11 ].…”

Corrigendum to “Self-Reported Adverse Drug Reactions, Medication Adherence, and Clinical Outcomes among Major Depressive Disorder Patients in Ethiopia: A Prospective Hospital Based Study”

“…In the article titled “Self-Reported Adverse Drug Reactions, Medication Adherence, and Clinical Outcomes among Major Depressive Disorder Patients in Ethiopia: A Prospective Hospital Based Study” [ 1 ], the name of the second author was given incorrectly as Lamessa Melese Sori. The author's name should have been written as Lamesa Melese Sori.…”