Self-reported alcohol consumption, carbohydrate deficient transferrin and risk of cardiovascular disease: The PREVEND prospective cohort study

Kunutsor, Setor K; Kremer, Daan; Eisenga, Michele F.; Gruppen, Eke G.; Borst, Martin H. de; Kobold, Anneke C. Muller; Kootstra‐Ros, Jenny E.; Dullaart, Robin P. F.; Bakker, Stephan J. L.

doi:10.1016/j.cca.2021.05.024

Cited by 4 publications

(1 citation statement)

References 44 publications

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“…Body mass index (BMI) was calculated using the standard formula: weight in kilograms divided by height in meters squared. Data on alcohol consumption were self-reported [65], utilizing a structured questionnaire with predefined categories over a one-month period, including options such as (i) none or almost never, (ii) 1-4 units/month, (iii) 2-7 units/week, (iv) 1-3 units/day, and (v) over 3 units/day. These responses were then converted into daily alcohol intake, with one drink in the Netherlands equating to 10 g of alcohol, irrespective of beverage type [40].…”

Section: Assessment Of Exposures and Other Risk Markersmentioning

confidence: 99%

Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings from the PREVEND Prospective Study

Kunutsor,

Bhattacharjee,

Connelly

et al. 2024

IJMS

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The associations of HDL particle (HDL-P) and subspecies concentrations with alcohol consumption are unclear. We aimed to evaluate the interplay between alcohol consumption, HDL parameters and cardiovascular disease (CVD) risk. In the PREVEND study of 5151 participants (mean age, 53 years; 47.5% males), self-reported alcohol consumption and HDL-P and subspecies (small, medium, and large) by nuclear magnetic resonance spectroscopy were assessed. Hazard ratios (HRs) with 95% CIs for first CVD events were estimated. In multivariable linear regression analyses, increasing alcohol consumption increased HDL-C, HDL-P, large and medium HDL, HDL size, and HDL subspecies (H3P, H4P, H6 and H7) in a dose-dependent manner. During a median follow-up of 8.3 years, 323 first CVD events were recorded. Compared with abstainers, the multivariable adjusted HRs (95% CIs) of CVD for occasional to light, moderate, and heavy alcohol consumers were 0.72 (0.55–0.94), 0.74 (0.54–1.02), and 0.65 (0.38–1.09), respectively. These associations remained consistent on additional adjustment for each HDL parameter. For CVD, only HDL-C was associated with a statistically significant decreased risk of CVD in a fully adjusted analysis (HR 0.84, 95% CI 0.72–0.97 per 1 SD increment). For coronary heart disease, HDL-C, HDL-P, medium HDL, HDL size, and H4P showed inverse associations, whereas HDL-C and HDL size modestly increased stroke risk. Except for H6P, alcohol consumption did not modify the associations between HDL parameters and CVD risk. The addition of HDL-C, HDL size, or H4P to a CVD risk prediction model containing established risk factors improved risk discrimination. Increasing alcohol consumption is associated with increased HDL-C, HDL-P, large and medium HDL, HDL size, and some HDL subspecies. Associations of alcohol consumption with CVD are largely independent of HDL parameters. The associations of HDL parameters with incident CVD are generally not attenuated or modified by alcohol consumption.

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Section: Assessment Of Exposures and Other Risk Markersmentioning

confidence: 99%

Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings from the PREVEND Prospective Study

Kunutsor,

Bhattacharjee,

Connelly

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

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Self-reported smoking, urine cotinine, and risk of type 2 diabetes: Findings from the PREVEND prospective cohort study

Kunutsor,

Tetteh,

Dey

et al. 2024

Primary Care Diabetes

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A burden of proof study on alcohol consumption and ischemic heart disease

Carr,

Bryazka,

McLaughlin

et al. 2024

Nat Commun

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Cohort and case-control data have suggested an association between low to moderate alcohol consumption and decreased risk of ischemic heart disease (IHD), yet results from Mendelian randomization (MR) studies designed to reduce bias have shown either no or a harmful association. Here we conducted an updated systematic review and re-evaluated existing cohort, case-control, and MR data using the burden of proof meta-analytical framework. Cohort and case-control data show low to moderate alcohol consumption is associated with decreased IHD risk – specifically, intake is inversely related to IHD and myocardial infarction morbidity in both sexes and IHD mortality in males – while pooled MR data show no association, confirming that self-reported versus genetically predicted alcohol use data yield conflicting findings about the alcohol-IHD relationship. Our results highlight the need to advance MR methodologies and emulate randomized trials using large observational databases to obtain more definitive answers to this critical public health question.

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Self-reported alcohol consumption, carbohydrate deficient transferrin and risk of cardiovascular disease: The PREVEND prospective cohort study

Cited by 4 publications

References 44 publications

Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings from the PREVEND Prospective Study

Alcohol Consumption, High-Density Lipoprotein Particles and Subspecies, and Risk of Cardiovascular Disease: Findings from the PREVEND Prospective Study

Self-reported smoking, urine cotinine, and risk of type 2 diabetes: Findings from the PREVEND prospective cohort study

A burden of proof study on alcohol consumption and ischemic heart disease

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