Self-reported bacterial vaginosis and risk of ultrasound-diagnosed incident uterine fibroid cases in a prospective cohort study of young African American women

Moore, Kristen R.; Baird, Donna D.

doi:10.1016/j.annepidem.2017.10.003

Cited by 9 publications

(22 citation statements)

References 23 publications

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“…Earlier studies have revealed that women who have been diagnosed with bacterial vaginosis were more likely to have multiple instead of single fibroids. 37 This is consistent with our study that found a positive association between vaginitis (OR = 4.05, 95% CI: 3.26-5.04) and the risk of developing uterine fibroids. The detailed pathogenesis of uterine fibroids has not been determined, but some studies have shown that hormones, inflammatory agents and signal transduction pathways are related to uterine fibroids.…”

Section: Discussionsupporting

confidence: 93%

Investigation on factors related to uterine fibroids in rural women of northern Anhui province

et al. 2021

J of Obstet and Gynaecol

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Aim: Given the increasing prevalence of hysteromyoma among the Chinese rural women of childbearing age, it is imperative that more attention should be given to researching risk factors that predispose women to this condition so that early preventive measures may be taken. Our study investigates potential risk factors for uterine fibroids such as participants' demographic characteristics (age, ethnicity, education), physiological characteristics (age at menarche, primiparous age), and the occurrence of several different female reproductive diseases (vaginitis, pelvic inflammatory disease). Methods: 2200 rural women of reproductive age were screened from a cross-sectional study carried out in the northern Anhui province. Data were collected by questionnaire surveys, gynecological and laboratory examinations and were subjected to univariate and multivariate analysis to evaluate the risk factors for uterine fibroids. Results: Of the 2200 women, 440 had uterine fibroids. In general, women with endometriosis, ovarian cysts and early menarche were more likely to suffer from hysteromyoma. Factors including higher parity, late age of first childbirth, and a regular menstrual cycle were associated with the reduced risk of uterine fibroids. Conclusions: Our findings indicate that parameters such as earlier age of menarche, early primiparous age, lower parity and a variety of female reproductive diseases were associated with an increased risk of uterine fibroids. These findings may be used to guide the formulation of effective prevention and intervention protocols to improve the reproductive health of rural women.

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Section: Discussionsupporting

confidence: 93%

Investigation on factors related to uterine fibroids in rural women of northern Anhui province

et al. 2021

J of Obstet and Gynaecol

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“…This was done because prior literature using self-report of history of BV had reported BV associations with number of fibroids and total fibroid volume. 6,7…”

Section: Statistical Analyses Hierarchical Regression Analysesmentioning

confidence: 99%

“…28 There have been 3 prior studies all reporting suggestive associations between BVand an increased risk of fibroids; however, all used self-reported doctor-diagnosed BV. [5][6][7] Relying on self-report of BV diagnosis is a major limitation because of the potential for misclassification due to reporting error and underdiagnosis. 29,30 Thus, because of the limitations of Nugent scoring and self-reported BV, the aim of this study is to use qPCR to investigate the relationship between the detection and quantity of specific BV-associated bacteria with uterine fibroids.…”

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confidence: 99%

Bacterial Vaginosis–Associated Bacteria and Uterine Fibroids: A Nested Case-Control Study

et al. 2021

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Background: Reproductive tract infections are hypothesized to influence uterine fibroid development, yet few studies have investigated the common condition of bacterial vaginosis (BV). The literature is currently limited to data using self-report of BV. Methods:We conducted a nested case-control study of 200 women (100 cases and 100 controls) from a large study of 23-to 35-year-old African American women, 1310 of whom were fibroid-free and prospectively followed up for 5 years to identify incident fibroids with standardized ultrasound examinations. We used quantitative polymerase chain reaction, an objective molecular method, to assess 9 BV-associated and 4 Lactobacillus species from vaginal swab specimens. We used hierarchical logistic regression to compute odds ratios and 95% confidence intervals to examine associations between bacterial species (both individually and grouped as (1) "optimal" Lactobacillus and (2) BV-associated species) with fibroid incidence and number. We also examined vaginal imbalance (quantitatively more BV-associated bacteria than optimal Lactobacilli).Results: Contrary to our hypothesis, we found no increase in fibroid incidence or number among women with more BV-associated bacteria. High imbalance (only BV-associated bacteria, no optimal Lactobacillus bacteria) was actually inversely associated with fibroid incidence (odds ratio, 0.38; 95% confidence interval, 0.17-0.81).

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“…Earlier study has observed women with incident fibroids, those with a previous BV diagnosis are more likely to have 2 or more fibroids compared with 1 fibroid 34 . This is consistent with our study that found a positive association between vaginitis (OR = 4.05, 95%CI: 3.26-5.04) and the risk of developing uterine leiomyomas.…”

Section: Discussionmentioning

confidence: 83%

Effects of menarche,parity,primiparous age,and reproductive diseases on uterine fibroids of rural women in China

Shao

Zhu

et al. 2019

Preprint

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Objectives With the increasing prevalence of hysteromyoma among Chinese rural women at childbearing age, it has become a priority to identify the risk factors that predispose to corporeity and promote early prevention. The aim of the study is to explore the relationship between menarche age, female reproductive health and uterine fibroids.Methods Study participants included 2,200 rural women of reproductive age who were screened for a cross-sectional study in the Anhui province. Data collected by questionnaire survey, gynecological and laboratory examinations were analyzed by Univariate and multivariate analysis to evaluate the risk factors for uterine fibroids.Results Of the 2,200 women, 440 had uterine fibroids. In general, women with endometriosis, ovarian cysts and early menarche were more likely to suffer from hysteromyoma. Factors including more parity, appropriate late primiparous age and normal menstrual cycle were protective of uterine fibroids.Conclusions Our findings indicate that a variety of modifiable factors may increase the risk of uterine fibroids and that relevant health departments should develop effective prevention and intervention measures to improve the reproductive health of rural women.

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Self-reported bacterial vaginosis and risk of ultrasound-diagnosed incident uterine fibroid cases in a prospective cohort study of young African American women

Cited by 9 publications

References 23 publications

Investigation on factors related to uterine fibroids in rural women of northern Anhui province

Investigation on factors related to uterine fibroids in rural women of northern Anhui province

Bacterial Vaginosis–Associated Bacteria and Uterine Fibroids: A Nested Case-Control Study

Effects of menarche,parity,primiparous age,and reproductive diseases on uterine fibroids of rural women in China

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