Self-reported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV

Lee, James T.; Saag, Lauren A.; Kipp, Aaron M.; Logan, James; Shepherd, Bryan E.; Koethe, John R.; Turner, Megan; Bebawy, Sally; Hulgan, Todd

doi:10.1007/s10461-019-02430-x

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…This relationship was also found in patients infected with chronic hepatitis B (Barré, Pol, et al, 2021). However, to our knowledge, no such data exist for HCVinfected persons, and the only results available for HIV-infected people found no evidence for an effect of cannabis use on changes in BMI (Lee et al, 2019). We did not find a significant dose-response relationship, despite the fact that aOR values for former and current use suggested the contrary.…”

Section: Discussionsupporting

confidence: 39%

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Cannabis Use as a Protective Factor Against Overweight in HIV-Hepatitis C Virus Co-Infected People (ANRS CO13 HEPAVIH Cohort)

Barré

Sogni

Zaegel-Faucher

et al. 2022

AIDS Education and Prevention

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Overweight is increasingly prevalent in people living with HIV (PLWH), and is a high risk factor for metabolic disorders in this population. PLWH co-infected with hepatitis C virus (HCV) have a higher risk of metabolic disorders than their mono-infected counterparts. The putative relationship between cannabis use and body weight found in the general population has never been documented in HIV-HCV co-infected people. We tested whether cannabis use is associated with body mass index (BMI), overweight, and underweight in HCV co-infected PLWH (N = 992). Mixed-effects linear and logistic regression models were used to study the association between cannabis use and the three outcomes over time. After multivariable adjustment, cannabis use was inversely associated with BMI. Cannabis use was associated with a lower and higher risk of overweight and underweight, respectively. Cannabis use should be assessed and taken into account in the clinical management of the HIV-HCV co-infected population.

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Section: Discussionsupporting

confidence: 39%

“…However, its impact on body weight is poorly documented in this population, and the only related result to date found no association with changes in BMI (Lee et al, 2019).…”

Section: Introductionmentioning

confidence: 84%

Cannabis Use as a Protective Factor Against Overweight in HIV-Hepatitis C Virus Co-Infected People (ANRS CO13 HEPAVIH Cohort)

Barré

Sogni

Zaegel-Faucher

et al. 2022

AIDS Education and Prevention

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“…A large single-site longitudinal study found no adverse effect of cannabis use on CD4 cell count. Similar to the Women's Interagency HIV Study (WIHS) and other studies, the use of any marijuana increased the likelihood of having a detectable viral load [6,192,193]. Among participants in the Veterans Aging Cohort Study (VACS), marijuana use was not associated with increased mortality, while psychostimulant use did confer additional risk [194].…”

Section: Effect Of Marijuana On Hivmentioning

confidence: 73%

Substance-Related and Addictive Disorders

et al. 2021

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“…In addition, a meta-analysis of clinical studies in African cohorts of men who have sex with men suggested that cannabis use was associated with a lower risk of acquiring HIV infection [ 35 ]. While these findings are countered by evidence of higher levels of HIV RNA in semen and increased risk of detectable viral load at clinic visits in HIV + cannabis users [ 67 , 68 ], the majority of clinical and in vivo evidence suggests cannabis use suppresses markers of viral replication.…”

Section: Cannabinoids × Hiv: Prevalence Cross Talk and Clinical Outcomesmentioning

confidence: 99%

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

Starr

Jordan‐Sciutto

Mironets

2021

Viruses

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The persistence of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) in the era of effective antiretroviral therapy suggests that modern HIV neuropathogenesis is driven, at least in part, by mechanisms distinct from the viral life cycle. Identifying more subtle mechanisms is complicated by frequent comorbidities in HIV+ populations. One of the common confounds is substance abuse, with cannabis being the most frequently used psychoactive substance among people living with HIV. The psychoactive effects of cannabis use can themselves mimic, and perhaps magnify, the cognitive deficits observed in HAND; however, the neuromodulatory and anti-inflammatory properties of cannabinoids may counter HIV-induced excitotoxicity and neuroinflammation. Here, we review our understanding of the cross talk between HIV and cannabinoids in the central nervous system by exploring both clinical observations and evidence from preclinical in vivo and in vitro models. Additionally, we comment on recent advances in human, multi-cell in vitro systems that allow for more translatable, mechanistic studies of the relationship between cannabinoid pharmacology and this uniquely human virus.

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Self-reported Cannabis Use and Changes in Body Mass Index, CD4 T-Cell Counts, and HIV-1 RNA Suppression in Treated Persons with HIV

Cited by 9 publications

References 32 publications

Cannabis Use as a Protective Factor Against Overweight in HIV-Hepatitis C Virus Co-Infected People (ANRS CO13 HEPAVIH Cohort)

Cannabis Use as a Protective Factor Against Overweight in HIV-Hepatitis C Virus Co-Infected People (ANRS CO13 HEPAVIH Cohort)

Substance-Related and Addictive Disorders

Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae

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