Self-reported concussion history: impact of providing a definition of concussion

Robbins, Clifford A.; Daneshvar, Daniel H.; Picano, John; Gavett, Brandon E.; Baugh, Christine M.; Riley, Donald E.; Nowinski, Christopher J.; McKee, Ann C.; Cantu, Robert C.; Stern, Robert A.

doi:10.2147/oajsm.s58005

Cited by 88 publications

(85 citation statements)

References 17 publications

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“…It is also possible that retrospective self-reporting of concussion history introduces significant error variance. 29 As stated previously, self-reported concussion history was not associated with cortical thickness. Follow-up analysis, however, revealed an "Age by Concussion History" interaction on cortical thickness in right ventrolateral prefrontal and right parietal regions.…”

Section: Discussionmentioning

confidence: 53%

Postconcussion Symptoms Are Associated with Cerebral Cortical Thickness in Healthy Collegiate and Preparatory School Ice Hockey Players

Albaugh

Orr

Nickerson

et al. 2015

The Journal of Pediatrics

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Section: Discussionmentioning

confidence: 53%

Postconcussion Symptoms Are Associated with Cerebral Cortical Thickness in Healthy Collegiate and Preparatory School Ice Hockey Players

Albaugh

Orr

Nickerson

et al. 2015

The Journal of Pediatrics

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“…Third, previous work has demonstrated that the operational definition of concussion can influence athletes' self-report of previous concussions. 56 The reliance on self-reported medically diagnosed concussions in the current work may have led to under-estimation, as many concussions go unreported. 57 Although we observed no significant relationship between the number of concussions and cortical thickness in football athletes with a history of concussion, alternative cutoff points (e.g., three or more concussions) and larger sample sizes should be used in future studies to investigate potential exposuredependent relationships with neuroanatomical measures.…”

Section: Limitationsmentioning

confidence: 99%

Thinner Cortex in Collegiate Football Players With, but not Without, a Self-Reported History of Concussion

Meier

Bellgowan

Bergamino

et al. 2016

Journal of Neurotrauma

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Emerging evidence suggests that a history of sports-related concussions can lead to long-term neuroanatomical changes. The extent to which similar changes are present in young athletes is undetermined at this time. Here, we tested the hypothesis that collegiate football athletes with (n = 25) and without (n = 24) a self-reported history of concussion would have cortical thickness differences and altered white matter integrity relative to healthy controls (n = 27) in frontotemporal regions that appear particularly susceptible to traumatic brain injury. Freesurfer software was used to estimate cortical thickness, fractional anisotropy was calculated in a priori white matter tracts, and behavior was assessed using a concussion behavioral battery. Groups did not differ in self-reported symptoms ( p > 0.10) or cognitive performance ( p > 0.10). Healthy controls reported significantly higher happiness levels than both football groups (all p < 0.01). Contrary to our hypothesis, no differences in fractional anisotropy were observed between our groups ( p > 0.10). However, football athletes with a history of concussion had significantly thinner cortex in the left anterior cingulate cortex, orbital frontal cortex, and medial superior frontal cortex relative to healthy controls ( p = 0.02, d = -0.69). Further, football athletes with a history of concussion had significantly thinner cortex in the right central sulcus and precentral gyrus relative to football athletes without a history of concussion ( p = 0.03, d = -0.71). No differences were observed between football athletes without a history of concussion and healthy controls. These results suggest that previous concussions, but not necessarily football exposure, may be associated with cortical thickness differences in collegiate football athletes.

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“…Control subjects were excluded if they had ever served in the military or had ever participated in any of the following organized sports: football, hockey, rugby, soccer, lacrosse, wrestling, boxing, basketball, gymnastics, martial arts, kickboxing, cycling, or distance running. Medical conditions that led to the exclusion of controls included self-reported history of concussion, 29 diagnosis of dementia, or medication that would make lumbar puncture unsafe.…”

Section: Participantsmentioning

confidence: 99%

Cavum Septi Pellucidi in Symptomatic Former Professional Football Players

Koerte

Hufschmidt

Muehlmann

et al. 2016

Journal of Neurotrauma

113

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Post-mortem studies reveal a high rate of cavum septi pellucidi (CSP) in chronic traumatic encephalopathy (CTE). It remains, however, to be determined whether or not the presence of CSP may be a potential in vivo imaging marker in populations at high risk to develop CTE. The aim of this study was to evaluate CSP in former professional American football players presenting with cognitive and behavioral symptoms compared with noncontact sports athletes. Seventytwo symptomatic former professional football players (mean age 54.53 years, standard deviation [SD] 7.97) as well as 14 former professional noncontact sports athletes (mean age 57.14 years, SD 7.35) underwent high-resolution structural 3T magnetic resonance imaging. Two raters independently evaluated the CSP, and interrater reliability was calculated. Within National Football League players, an association of CSP measures with cognitive and behavioral functioning was evaluated using a multivariate mixed effects model. The measurements of the two raters were highly correlated (CSP length: rho = 0.98; Intraclass Correlation Coefficient [ICC] 0.99; p < 0.0001; septum length: rho = 0.93; ICC 0.96; p < 0.0001). For presence versus absence of CSP, there was high agreement (Cohen kappa = 0.83, p < 0.0001). A higher rate of CSP, a greater length of CSP, as well as a greater ratio of CSP length to septum length was found in symptomatic former professional football players compared with athlete controls. In addition, a greater length of CSP was associated with decreased performance on a list learning task (Neuropsychological Assessment Battery List A Immediate Recall, p = 0.04) and decreased test scores on a measure of estimate verbal intelligence (Wide Range Achievement Test Fourth Edition Reading Test, p = 0.02). Given the high prevalence of CSP in neuropathologically confirmed CTE in addition to the results of this study, CSP may serve as a potential early in vivo imaging marker to identify those at high risk for CTE. Future research is needed to investigate the pathomechanism underlying the development of CSP after repetitive head impacts, and its potential association with neuropathologically confirmed CTE.

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Self-reported concussion history: impact of providing a definition of concussion

Cited by 88 publications

References 17 publications

Postconcussion Symptoms Are Associated with Cerebral Cortical Thickness in Healthy Collegiate and Preparatory School Ice Hockey Players

Postconcussion Symptoms Are Associated with Cerebral Cortical Thickness in Healthy Collegiate and Preparatory School Ice Hockey Players

Thinner Cortex in Collegiate Football Players With, but not Without, a Self-Reported History of Concussion

Cavum Septi Pellucidi in Symptomatic Former Professional Football Players

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