Self-reported Depressive Symptoms in Myasthenia Gravis

Fisher, Justin; Parkinson, Kari; Kothari, Milind J.

doi:10.1097/00131402-200303000-00001

Cited by 22 publications

(26 citation statements)

References 33 publications

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“…This is in accordance with the findings of Hong [13], who found that 36.21% of the studied sample suffered from depression using the Hamilton Depression scale. A similar percentage was reported by Fisher et al [14], who evaluated 45 MG patients with a self-administered survey scored according to the Beck Depression Inventory guidelines.…”

Section: Discussionsupporting

confidence: 66%

“…Many studies revealed the same conclusion [16,12,20,17,21,14,22,23,13,24]. This is in accordance with the assumption that the cause of psychiatric morbidity is the chronic and disabling characteristics of MG, which lead to restrictions in all aspects of life, decrease the quality of life, and cause prominent psychological stress.…”

Section: Discussionsupporting

confidence: 65%

“…Same was concluded in the study by Paradis and colleagues [16,22,14,23,13,20,21,24], who reported that negative association could be understood in the light of the pathophysiology and etiology of substance use disorders. Considering the self-medication theory, it can be assumed that the insidious onset, fluctuating clinical picture, and the continuous impending risk for crisis make the MG patients more cautious about their physical health state and could not take the risk of abusing any illicit substance [25].…”

Section: Discussionmentioning

confidence: 55%

“…It was developed by Besinger et al [10] and modified to perform an inter-rater reliability in 1998. It classifies clinical severity of MG into four classes: clinically free (0); mild severity (1-13); moderate severity (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26); and severe (27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39). It had been recommended by 'The Myasthenia Gravis Foundation of America Inc.' to be used in all prospective clinical trials in MG.…”

Section: Methodsmentioning

confidence: 99%

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Myasthenia gravis and psychiatric comorbidities

El-Ghonemy¹,

Salem²,

Elmissiry³

et al. 2016

Middle East Current Psychiatry

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BackgroundMyasthenia gravis (MG) is a chronic, autoimmune disease involving neuromuscular junctions frequently associated with psychiatric morbidity in terms of depression and anxiety. The interaction between MG and psychiatric disorders needs to be appreciated, especially in the primary care setting, as the symptoms may overlap. The main objective of this study was to recognize the rate of occurrence of psychiatric morbidity among MG patients and to assess the demographic variations of patients and its relevance. Participants and methodsA descriptive cross-sectional study was conducted during the period between June 2011 and December 2013 at the Neurology Department, Nasser Institute Hospital. Thirty MG patients from outpatients' clinics/inpatients' wards of Nasser Institute Hospital between 18 and 50 years of age and both sexes were included. The patients were subjected to clinical interview according to the protocol followed at the neuropsychiatry department of Ain Shams Faculty of Medicine, the quantitative myasthenia gravis test, and the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th ed. ResultsThe results showed that 27 (90%) patients had psychiatric comorbidity. Major depressive disorder (MDD) was found in 13 (43.3%) patients and dysthymic disorder was seen in only 7 (23.3%) patients. Anxiety disorders were found in 10 (33.3%) patients; adjustment disorders were found in two patients and mixed anxiety depressive disorder was found in two patients (6.7% for each). The most frequent anxiety disorder was generalized anxiety disorder (16.7%), followed by obsessive-compulsive disorder and social phobia (10% each), and panic disorder (PD) and agoraphobia (6.7% each). There was a significant correlation between the myasthenia severity index of the patient and his chance to have MDD of moderate severity. In addition, there was a significant association between MDD of mild severity and number of hospitalizations (P = 0.047), number of ICU admissions (P = 0.034), and number of myasthenic crisis (P = 0.038). There was a statistically significant association between severe MDD and number of plasmapharesis settings (P = 0.04). Moreover, there was also a statistically significant association between PD and number of myasthenic crisis (P = 0.042) and between agoraphobia without history of PD and number of hospitalizations (P = 0.048). Conclusion A high association of psychiatric comorbidities with MG of up to 90% was seen in the current study. The most common psychiatric comorbidities are depressive disorders and anxiety disorders. The disease characteristics for MG are the most common variables to have a significant correlation with the rate of psychiatric comorbidities, especially disease duration and severity.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 55%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Myasthenia gravis and psychiatric comorbidities

El-Ghonemy¹,

Salem²,

Elmissiry³

et al. 2016

Middle East Current Psychiatry

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“…2 Previous research on the psychological consequences of MG is scarce; however, there are indicators that the disease can have psychosocial consequences, with MG patients displaying higher levels of depression than population norms. 3 Ptosis occurs in the majority of MG patients, with 15% of MG patients experiencing ocular MG in isolation. 4 Although research into ptosis has mainly focused on functional elements of the condition, Bullock et al 5 concluded that ptosis can have negative social impacts and that there may be significant psychosocial benefits to corrective surgery.…”

Section: Introductionmentioning

confidence: 99%

The Psychosocial Impact of Ptosis as a Symptom of Myasthenia Gravis: A Qualitative Study

Richards

Jenkinson

Rumsey

et al. 2014

Orbit

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The aim of this qualitative study was to investigate the psychosocial impact of ptosis as a symptom of Myasthenia Gravis (MG). Participants were recruited from a MG patient group on Facebook. 166 participants answered a series of open ended questions examining the impact of ptosis, and responses were analysed using Inductive Thematic Analysis, which revealed four main themes. The first highlighted the extent to which ptosis impacted negatively on psychosocial functioning. The second related to ways in which ptosis can be framed in a positive way, eg, as a believable symptom. The final two themes revealed the complex inter-relationships between functional and appearance-related impacts, and a desire from many participants for health care professionals to provide more support directly related to their ptosis. This study suggests that ptosis impacts in ways not currently recognized in literature and practice.

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Prevalence of depression and anxiety among myasthenia gravis (MG) patients: A systematic review and meta‐analysis

et al. 2022

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Objective Myasthenia gravis (MG) people experience adverse psychiatric outcomes, which may impact on their life and disturb their daily activity. Depression and anxiety are identified as significant psychiatric problems that MG people face. However, there is no sufficient epidemiological information about depression and anxiety‐based publication. Due to this limitation, the aim of this study was to review the prevalence of depression and anxiety in MG patients. Methods Original and international databases were searched to find papers about the estimation of anxiety and depression. Random‐effects analysis was used for calculating the proportions of anxiety and depression. For estimating anxiety and depression based the severity, instruments, type of studies, and study regions, subgroup analysis was performed. Results 38 studies met inclusion criteria and entered study. The pooling of the prevalence of depression was found at 36%, (95% CI 28% to 45%). Also, prevalence of anxiety was found at 33%, (95% CI 25% to 42%). Prevalence of depression based on mild, moderate, and severe level was 27%, 14%, and 9%, respectively. Conclusions Anxiety and depression are a major concern among MG individuals. The estimation of both anxiety and depression are high even when compared to other autoimmune diseases. It seems depression and anxiety are important issues and more attention needs to be paid to these psychiatric disorders.

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Self-reported Depressive Symptoms in Myasthenia Gravis

Cited by 22 publications

References 33 publications

Myasthenia gravis and psychiatric comorbidities

Myasthenia gravis and psychiatric comorbidities

The Psychosocial Impact of Ptosis as a Symptom of Myasthenia Gravis: A Qualitative Study

Prevalence of depression and anxiety among myasthenia gravis (MG) patients: A systematic review and meta‐analysis

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