Self-Reported Food-Related Gastrointestinal Symptoms in IBS Are Common and Associated With More Severe Symptoms and Reduced Quality of Life

Böhn, Lena; Störsrud, Stine; Törnblom, Hans; Bengtsson, Ulf; Simrén, Magnus

doi:10.1038/ajg.2013.105

Cited by 528 publications

(431 citation statements)

References 53 publications

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“…The mere presence of gastrointestinal complaints does not allow conclusions about the genesis of the disease, although the diagnosis of an IBS is very frequently 2, 7, 30. The prevalence of IBS is significantly higher in women than in men 35.…”

Section: Discussionmentioning

confidence: 99%

“…Due to the increasing incidence of food intolerances in industrial nations and the associated restriction of quality of life, a close look at nutrition becomes increasingly important 1, 2, 3…”

Section: Introductionmentioning

confidence: 99%

“…Consequently, this is provoking disorders within a short time lag from hours up to days. High histamine levels in the body are not only caused by reduced DAO activities but also by the ingestion of histamine‐rich and histamine‐releasing foods such as meat, dairy products and alcohol 2, 13, 14…”

Section: Introductionmentioning

confidence: 99%

“…Histamine intolerance has already been reported as a causal trigger for cardinal gastrointestinal disorders like abdominal pain, diarrhoea and flatulence 2, 15, 16. On the one hand, the patients' clinical presentation can resemble other food intolerances or allergy and is usually diagnosed under the umbrella of irritable bowel syndrome (IBS) 2, 7.…”

Section: Introductionmentioning

confidence: 99%

“…On the one hand, the patients' clinical presentation can resemble other food intolerances or allergy and is usually diagnosed under the umbrella of irritable bowel syndrome (IBS) 2, 7. On the other hand, histamine intolerance is also characterized by extra‐intestinal symptoms such as headache,15 pruritus,16 urticaria,17 atopic eczema,18 cardiac arrhythmia19 and asthma13, 14 that exceed the diagnosis of IBS.…”

Section: Introductionmentioning

confidence: 99%

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Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer

Tietz

Waldmann

et al. 2017

Allergy

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BackgroundHistamine intolerance is thought to trigger manifold clinical symptoms after ingesting histamine‐rich food due to reduced activity of diamine oxidase (DAO). No study has hitherto systematically assessed daily fluctuations of histamine levels and DAO activities in symptomatic patients. The aim of the study was to investigate the presence of histamine intolerance, to therefore establish day profiles of histamine levels and DAO activities, and to compare the results between patients with suspected histamine intolerance, food allergy and healthy controls.MethodsWe determined day profiles of histamine plasma levels and DAO serum activities in 33 patients with suspected histamine intolerance, in 21 patients with proven food allergy and in 10 healthy control patients. Clinical symptoms, food intolerances and further clinical and laboratory chemical parameters were evaluated.ResultsTwenty‐four percent (8 of 33) suspected histamine‐intolerant patients showed elevated histamine levels during the day. That might be caused by constantly and significantly reduced DAO activities in these patients compared to food‐allergic and control patients. The remaining 25 patients presented normal histamine levels and DAO activities, but an increased prevalence of multiple food intolerances compared to the other subgroup of suspected histamine‐intolerants. There was no correlation between subjective complaints and serological histamine parameters in patients with suspected histamine intolerance.ConclusionsWe determined by daily profiling that decreased DAO activities correlated with elevated histamine levels in a subgroup of suspected histamine‐intolerants. This finding discriminates these patients from food intolerant individuals with similar clinical symptoms and strongly suggests the presence of histamine intolerance.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Pinzer

Tietz

Waldmann

et al. 2017

Allergy

View full text Add to dashboard Cite

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Irritable Bowel Syndrome

Ford

2019

Evidence‐based Gastroenterology and Hepatology 4e

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INTRODUCTION: The prevalence of irritable bowel syndrome (IBS) varies depending on the criteria used to diagnose it, but it ranges from about 5% to 20%. IBS is associated with abnormal gastrointestinal motor function and enhanced visceral perception, as well as psychosocial and genetic factors. People with IBS often have other bodily and psychiatric symptoms, and have an increased likelihood of having unnecessary surgery compared with people without IBS. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of treatments in people with IBS? We searched: Medline, Embase, The Cochrane Library, and other important databases up to August 2011 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found 27 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. CONCLUSIONS: In this systematic review we present information relating to the effectiveness and safety of the following interventions: 5HT 3 receptor antagonists (alosetron and ramosetron), 5HT 4 receptor agonists (tegaserod), antidepressants (tricyclic antidepressants and selective serotonin reuptake inhibitors [SSRIs]), antispasmodics (including peppermint oil), cognitive behavioural therapy (CBT), hypnotherapy, loperamide, and soluble and insoluble fibre supplementation.

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Cross‐Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment

Li,

Ghosh,

Arendt

et al. 2024

Advanced Science

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Irritable bowel syndrome (IBS) is a prevalent disorder of gut‐brain interaction without a reliable cure. Evidence suggests that an alteration of the gut microbiome may contribute to IBS pathogenesis, motivating the development of microbiome‐targeted therapies to alleviate IBS symptoms. However, IBS‐specific microbiome signatures are variable across cohorts. A total of 9204 datasets were meta‐analyzed, derived from fourteen IBS microbiome discovery cohorts, three validation cohorts for diet‐microbiome interactions, and five rifaximin therapy cohorts. The consistent bacterial species and functional signatures associated with IBS were identified. Network analysis revealed two distinct IBS‐enriched microbiota clusters; obligate anaerobes that are found commonly in the gut, and facultative anaerobes typically present in the mouth, implying a possible association between oral bacterial translocation to gut and IBS pathogenesis. By analyzing diet‐microbiome interactions, microbiota‐targeted diets that can potentially modulate the altered gut microbiota of IBS subjects toward a healthy status were identified. Furthermore, rifaximin treatment of IBS subjects was linked with a reduction in the abundance of facultatively anaerobic pathobionts. Gut microbiome signatures were identified across IBS cohorts that may inform the development of therapies for microbiome modulation in IBS. The microbiota‐targeted diet patterns described may enable nutritional intervention trials in IBS and for assisting dietary management.

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Self-Reported Food-Related Gastrointestinal Symptoms in IBS Are Common and Associated With More Severe Symptoms and Reduced Quality of Life

Cited by 528 publications

References 53 publications

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Circadian profiling reveals higher histamine plasma levels and lower diamine oxidase serum activities in 24% of patients with suspected histamine intolerance compared to food allergy and controls

Irritable Bowel Syndrome

Cross‐Cohort Gut Microbiome Signatures of Irritable Bowel Syndrome Presentation and Treatment

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