Self-reported hypoglycemia in insulin-treated patients with diabetes: Results from an international survey on 7289 patients from nine countries

Emral, Rıfat; Pathan, Faruque; Cortés, Carlos Augusto Yepes; El-Hefnawy, Mohamed H; Goh, Su‐Yen; Gómez, Ana María; Murphy, Angela; Abusnana, Salah; Rudijanto, Achmad; Jain, Anand; Ma, Zeyu; Mirasol, Roberto

doi:10.1016/j.diabres.2017.07.031

Cited by 46 publications

(54 citation statements)

References 33 publications

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“…The International Operations Hypoglycemia Assessment Tool (IO HAT) builds on information gathered as part of the GLOBAL HAT study [12]. This study was an international, multicenter study designed to assess the incidence of hypoglycemia in DM patients treated with insulin (pre-mix, short-acting, long-acting, or insulin pump) in Bangladesh, Colombia, Egypt, Indonesia, the Philippines, Singapore, South Africa, Turkey, and United Arab Emirates [13]. This sub-analysis of Egyptian diabetes patients was performed with an aim to assess the incidence and rates of hypoglycemia, the relationship between hypoglycemia and HbA1c levels, and how hypoglycemic events affected healthcare resources in Egypt.…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemia among Insulin-treated Patients with Diabetes: Egypt Cohort of IO HAT Study

Hefnawy¹,

Abdelaaty²,

Bassyouni³

et al. 2018

TODIAJ

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Objectives:The study aims to assess the real-world incidence of hypoglycemia in patients with Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM) in Egypt cohort of the International Operations Hypoglycemia Assessment Tool (IO HAT) study. Methods:This is a non-interventional study to estimate hypoglycemia in eligible patients with T1DM or T2DM, aged ≥18 years and treated with insulin for >12 months, who have completed self-assessment questionnaires to record demography, treatment information, and hypoglycemia during the 6-month/4-week retrospective and 4-week prospective periods. Data on hypoglycemia for this sub-analysis were collected from DM patients of Egyptian cohort who were recruited in IO HAT study across 36 sites in Egypt between 22 Nov 2014 and 15 Apr 2015. Results:Percentage of patients who reported at least one hypoglycemic event in the prospective period was any: T1DM: 96.3% (95% confidence interval [CI]. An estimated rate of any and severe hypoglycemia in the prospective period was 63.3 (95% CI: 57.2, 69.9) events per patient year (PPY) and 28.9 (95% CI: 24.8, 33.4) events PPY, respectively, for patients with T1DM and 32.0 (95% CI: 29.8, 34.3) events PPY and 15.5 (95% CI: 14.0, 17.1) events PPY, respectively, for patients with T2DM. Hypoglycemic rate was independent of glycated hemoglobin levels. Conclusion:The self-reported hypoglycemia data from Egypt confirms that hypoglycemia is under-reported. The high impact of hypoglycemia on the Egyptian DM patients and healthcare system warrants patient education to prevent hypoglycemia.

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Section: Introductionmentioning

confidence: 99%

Hypoglycemia among Insulin-treated Patients with Diabetes: Egypt Cohort of IO HAT Study

Hefnawy¹,

Abdelaaty²,

Bassyouni³

et al. 2018

TODIAJ

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“…Glycaemic control was determined by baseline HbA1c measurements, with percentages of >9%, 7-9% and <7% indicating poor, suboptimal and good glycaemic control, respectively. Comprehensive details of the design of the IO-HAT study and the procedures used for the assessment of hypoglycaemia have been previously reported by Emral et al 11 The percentages of patients experiencing at least one hypoglycaemic event during the four-week prospective period were calculated along with 95% confidence intervals (CIs). Rates of hypoglycaemia were deemed equivalent in the retrospective and prospective periods according to two-sided statistical tests with the level of statistical significance set at P ≤0.050.…”

Section: Methodsmentioning

confidence: 99%

“…10 In 2017, the International Operations-Hypoglycaemia Assessment Tool (IO-HAT) study was conducted to determine the prevalence and incidence rates (IRs) of hypoglycaemic events among 7,289 insulin-treated patients with T1DM and T2DM in Bangladesh, Colombia, Egypt, Indonesia, the Philippines, Singapore, South Africa, Turkey and the United Arab Emirates (UAE). 11 The IO-HAT study was itself based on data gathered as part of a larger investigation of 27,585 adult patients from 24 countries. 12 The current study aimed to determine the incidence of hypoglycaemia among the UAE cohort of the IO-HAT study.…”

mentioning

confidence: 99%

“…12 The current study aimed to determine the incidence of hypoglycaemia among the UAE cohort of the IO-HAT study. 11 In addition, the patients' knowledge of and attitudes towards hypoglycaemia were assessed, as well as the relationship between the incidence of hypoglycaemia and insulin regimens and glycaemic control, as determined by baseline glycated haemoglobin (HbA1c) measurements.…”

mentioning

confidence: 99%

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Hypoglycaemia Among Insulin-Treated Patients with Diabetes: Evaluation of the United Arab Emirates cohort of the International Operations-Hypoglycaemia Assessment Tool study

Abusnana

Beshyah

Al-Mutawa

et al. 2019

Sultan Qaboos Univ Med J

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Objectives: This study aimed to evaluate the incidence of hypoglycaemia among insulin-treated patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) from the United Arab Emirates (UAE) cohort of the non-interventional International Operations-Hypoglycaemia Assessment Tool study. Methods: This cross-sectional observational study took place at 25 patient care centres in the UAE from October 2014 to May 2015. All adult patients with T1DM or T2DM who had been treated with insulin for >12 months were included. Self-assessment questionnaires and patient diaries were used to determine the incidence of documented hypoglycaemia both prospectively (four weeks after baseline) and retrospectively (six months and four weeks before baseline for severe and non-severe hypoglycaemic events, respectively). Results: A total of 325 patients were enrolled in the study, of which 82 (25.2%) had T1DM and 243 (74.8%) had T2DM. Among patients with T1DM, 71.4% reported hypoglycaemic events retrospectively, with an incidence rate (IR) of 102.8 events per patient-year (PY), while 95% reported hypoglycaemic events prospectively, with an IR of 63.1 events per PY. Additionally, 56.3% of patients with T2DM reported hypoglycaemic events retrospectively, with an IR of 42.2 events per PY, while 91.9% reported hypoglycaemic events prospectively, with an IR of 33.3 events per PY. Conclusion: The prevalence and incidence of hypoglycaemia were high among insulin-treated patients with T1DM and T2DM in the UAE. Individualised glycaemic goals, patient education and blood glucose monitoring may help to reduce the incidence of hypoglycaemia in this population.Keywords: Hypoglycemia; Insulin; Type 1 Diabetes Mellitus; Type 2 Diabetes Mellitus; United Arab Emirates.

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“…11 The aim of this sub-analysis was to assess the incidence and rates of hypoglycaemia in insulin-treated patients with T1DM or T2DM in the South African cohort.…”

Section: Introductionmentioning

confidence: 99%

Incidence of hypoglycaemia among insulin-treated patients with type 1 or type 2 diabetes mellitus: South African cohort of International Operations Hypoglycaemia Assessment Tool (IO HAT) study

Omar

Kok²,

Khutsoane

et al. 2017

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Objectives: To assess the incidence and rates of hypoglycaemia in patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) in the South African cohort of the International Operations Hypoglycaemia Assessment Tool (IO HAT) study. Methods: Patients diagnosed with either T1DM or T2DM, aged ≥ 18 years and treated with insulin for > 12 months, completed selfassessment questionnaires to record demography, treatment information and hypoglycaemia during a 6-month retrospective and 4-week prospective periods (ClinicalTrials.gov: NCT02306681). Results: In T1DM 76.2% (95% confidence interval [CI] 69.1%, 82.3%) of patients reported hypoglycaemia in the retrospective period and 98.2% (95% CI 94.7%, 99.6%) in the prospective period. The corresponding figures for patients with T2DM were 52.2% (95% CI 48.6%, 55.9%) and 90.1% (95% CI 87.7%, 92.3%), respectively. Rates of any and severe hypoglycaemia, respectively were T1DM 90.7 events per patient year (PPY) (95% CI 85.5, 96.1) and 8.8 events PPY (95% CI 7.2, 10.6) and T2DM 45.7 events PPY (95% CI 43.9, 47.5) and 8.9 events PPY (95% CI 8.1, 9.8) during the prospective period. The rates of hypoglycaemia were independent of glycated haemoglobin levels. Conclusions: This is the first patient dataset of self-reported hypoglycaemia in South Africa; results showed that hypoglycaemia is under-reported.

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Self-reported hypoglycemia in insulin-treated patients with diabetes: Results from an international survey on 7289 patients from nine countries

Cited by 46 publications

References 33 publications

Hypoglycemia among Insulin-treated Patients with Diabetes: Egypt Cohort of IO HAT Study

Hypoglycemia among Insulin-treated Patients with Diabetes: Egypt Cohort of IO HAT Study

Hypoglycaemia Among Insulin-Treated Patients with Diabetes: Evaluation of the United Arab Emirates cohort of the International Operations-Hypoglycaemia Assessment Tool study

Incidence of hypoglycaemia among insulin-treated patients with type 1 or type 2 diabetes mellitus: South African cohort of International Operations Hypoglycaemia Assessment Tool (IO HAT) study

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