Self-reported IBS and gastrointestinal symptoms in the general population are associated with asthma, drug consumption and a family history of gastrointestinal diseases

Ruderstam, Hanna; Ohlsson, Bodil

doi:10.1080/00365521.2022.2031281

Cited by 7 publications

(12 citation statements)

References 38 publications

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“…Thirdly, 1,577 participants of the 4,225 participants included between March 2013 and June 2020 (46.7% participation rate) were excluded due to the presence of any type of organic GI disease or due to their inability to provide an answer to the questions regarding GI symptoms. Therefore, 2,648 individuals were finally included in the study of sociodemographic factors ( 25 ), chronic stress and sleeping habits ( 26 ), concomitant diseases, drug use, and family history of any diseases ( 27 ) ( Fig. 1 ; Table I ).…”

Section: Mosmentioning

confidence: 99%

“…When examining comorbidity, asthma was associated with self-reported IBS. The associations between asthma and GI symptoms in the past 2 weeks and chest pain >30 min and IBS disappeared following adjustment for FDR ( 27 ).…”

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

“…IBS was associated with prescription of drugs in the past week or the use of a non-prescription drug in the past week. When calculations were performed with specific medications, antihistamines, beta blockers, and hypnotics were the drugs associated with IBS ( 27 ).…”

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

“…GI symptoms in the past 2 weeks were associated with non-prescription drugs prior to FDR correction, as well as the prescribed drugs beta-blockers and proton pump inhibitors ( 27 ).…”

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

“…In addition, there was an association between GI disease in the family and self-reported IBS and GI symptoms. Regarding the subgroups of GI diseases, IBS was associated with celiac disease, gastric ulcer, functional dyspepsia, IBS, and reflux; GI symptoms were associated with functional dyspepsia, IBS, and reflux ( 27 ).…”

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

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Functional bowel symptoms in the general population (Review)

Ohlsson

2022

Mol Med Rep

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Several patients with irritable bowel syndrome (IBS) do not seek medical attention for their symptoms. When patients with IBS seek help, the majority of them are handled at primary healthcare centers, whereas research studies are performed at tertiary healthcare centers. The present study aimed to summarize findings from >4,000 participants of the general population included in the Malmö Offspring Study (inclusion rate 46.7%). The participants were clinically examined, their blood and fecal samples collected, and their questionnaires completed. The participants were divided into subjects with or without self-reported IBS and those having functional gastrointestinal (GI) symptoms in the past 2 weeks. The presence of IBS and GI symptoms in the participants were associated with each other. Zonulin levels did not differ between participants with or without GI diseases and were not associated with the degree of GI symptoms. The parameters low body weight at birth and small for gestational age were associated with the degree of the symptoms' influence on daily life. IBS and GI symptoms were positively associated with Blautia abundance. Beta-diversity differed between participants with or without these two conditions. Positive correlations were noted between the degree of diarrhea and the mean 24-h measurements of systolic blood pressure, diastolic blood pressure, and heart rate. Both IBS and GI symptoms were associated with female sex, smoking, stress, poor sleeping habits, unemployment, drug use, and a family history of GI diseases, whereas younger age was inversely associated with IBS and its associated symptoms. In conclusion, only a limited number of medical findings could be identified in participants with IBS and GI symptoms, whereas sociodemographic and environmental conditions were associated with these entities.

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Section: Mosmentioning

confidence: 99%

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

“…GI symptoms in the past 2 weeks were associated with non-prescription drugs prior to FDR correction, as well as the prescribed drugs beta-blockers and proton pump inhibitors ( 27 ).…”

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

Section: Self-reported Ibs or Gi Symptoms And Comorbidity Medication ...mentioning

confidence: 99%

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Functional bowel symptoms in the general population (Review)

Ohlsson

2022

Mol Med Rep

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Prevalence and impact of disorders of Gut–Brain interaction in Sweden

Tornkvist

Simrén

Hreinsson

et al. 2023

Neurogastroenterology Motil

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Background Previous epidemiologic studies in Sweden have only covered some of the disorders of gut–brain interaction (DGBI) and are not representative of the general population. This study aimed to define the prevalence and impact of DGBI in Sweden. Methods We used Swedish data from the Rome Foundation Global Epidemiology Study which include information on DGBI diagnoses, psychological distress, quality of life (QoL), healthcare utilization, and the impact of stress on GI symptoms. Key Results The prevalence of having any DGBI was 39.1% (95% CI 37.0–41.2); esophageal disorders 6.1% (5.1–7.3), gastroduodenal disorders 10.7% (9.3–12.0), bowel disorders 31.6% (29.6–33.6), and anorectal disorders 6.0% (5.1–7.2). Subjects with a DGBI more commonly reported anxiety and/or depression, reduced mental and physical QoL, and more frequent doctor visits due to health problems. Subjects with a DGBI reported bothersome gastrointestinal (GI) symptoms to a greater extent and more than 1/3 had visited a doctor due to GI problems and of those 1/3 had seen multiple doctors. Prescription medications were available among 36.4% (31.0–42.0) who had bothersome GI symptoms and a DGBI, with sufficient symptom relief in 73.2% (64.0–81.1). Psychological factors and eating were reported to worsen GI symptoms and stress during the last month was greater in subjects with a DGBI. Conclusions and Inferences DGBI prevalence and its impact in Sweden is in line with global data, including increased healthcare utilization. GI symptoms are commonly affected by psychological factors and eating, and a high proportion of those on prescription medication report sufficient GI symptom relief.

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Prevalence of extra‐intestinal symptoms according to irritable bowel syndrome subtype

Pereyra,

Bustos Fernández,

Schlottmann

et al. 2024

Neurogastroenterology Motil

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BackgroundIrritable bowel syndrome (IBS) is a functional disorder commonly associated with extra‐intestinal symptoms. However, the prevalence of these symptoms according to IBS subtype is not well established.AimTo compare the prevalence of extra‐intestinal symptoms among patients with different subtypes of IBS.MethodsA descriptive cross‐sectional study including patients with IBS according to Rome IV criteria was performed between July 2022 and April 2023. Patients were classified according their subtype of IBS: IBS‐D (diarrhea‐predominant), IBS‐C (constipation‐predominant), and IBS‐M (mixed bowel habits). Patients completed the IBS severity scoring system questionnaire (IBS‐SSS) to determine severity of IBS symptoms and patient health questionnaire‐ 9 (PHQ‐9) to define presence and severity of depressive symptoms. The prevalence of reported extra‐intestinal symptoms was also assessed and compared between groups.Key ResultsA total of 4862 patients with IBS were included; 608 IBS‐D (12.5%), 1978 IBS‐C (40.7%), and 2276 IBS‐M (46.8%). Patients with IBS‐C had significantly lower IBS‐symptoms severity (mean IBS‐SSS 290 vs. 310 and 320 for IBS‐D and IBS‐M, respectively, p = 0.03). The prevalence of obesity was also significantly lower in these patients (17.1% vs. 30.9% IBS‐D and 27.9% IBS‐M, p = 0.0001). Patients with IBS‐D showed a significantly higher prevalence of food intolerance perception (9.5%, p = 0.03), history of cholecystectomy (17.8%, p = 0.03), and fecal incontinence (36.2%, p = 0.0001) as compared to the other groups. Patients with IBS‐M had significantly higher mean PHQ‐9 score (12.7 vs. 11.1 IBS‐D and 10.5 IBS‐C, p = 0.001) and prevalence of depressive symptoms (80.0%, p = 0.01). Patients with IBS‐M also had higher prevalence of extra‐intestinal symptoms such as arthralgia (62.4%, p = 0.0001), extremity numbness (64.5%, p = 0.0001), atopic dermatitis (28.2%, p = 0.02), and chronic cervicalgia (81.0%, p = 0.01).Conclusions & InferencesThe prevalence of most extra‐intestinal symptoms is higher among patients with IBS‐M. Further research is needed to better characterize IBS subtypes, which could potentially help refining tailored therapeutic strategies.

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Self-reported IBS and gastrointestinal symptoms in the general population are associated with asthma, drug consumption and a family history of gastrointestinal diseases

Cited by 7 publications

References 38 publications

Functional bowel symptoms in the general population (Review)

Functional bowel symptoms in the general population (Review)

Prevalence and impact of disorders of Gut–Brain interaction in Sweden

Prevalence of extra‐intestinal symptoms according to irritable bowel syndrome subtype

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