Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry

Kim, Seong-Kyu; Choe, Jung Yoon; Lee, Shin Seok

doi:10.3349/ymj.2018.59.7.857

Cited by 11 publications

(18 citation statements)

References 38 publications

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“…In our multivariate analysis, IL-23R + Th cells and SLEDAI-2K association was dependent on age in our SLE cohort, tallying with the univariate comparison where younger SLE patients had a significantly higher proportion of IL-23R + Th cells. These observations are comparable with independent studies in which younger SLE patients are more likely to present with nephritis and greater organ damage (59)(60)(61)(62), and more likely to be hospitalized with SLE as a diagnosis (59). Whether an increased proportion IL-23R + Th cells plays a direct, causative role in exacerbating disease activities in younger SLE patients remains to be elucidated.…”

Section: Discussionsupporting

confidence: 89%

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

et al. 2021

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The IL-23/IL-17 axis plays causative roles in the development and progression of systemic lupus erythematosus (SLE). However, it remains unclear if the IL-17RA+ and IL-23R+ T helper (Th) cells populations are associated with the serum IL-17 and IL-23 levels, or with the immunological parameters and disease activities in SLE patients. Herein, we examined the proportion of IL-17RA+ and IL-23R+ Th cells and serum levels of IL-17 and IL-23 in established SLE patients (n = 50) compared with healthy controls (n = 50). The associations of these interleukins and their receptors with immunological parameters [anti-nuclear antibody (ANA), anti-dsDNA antibody, and C-reactive protein (CRP)] and SLE disease activity (SLEDAI-2K scores) in SLE patients were assessed. CD3+CD4+ Th cells of SLE patients demonstrated significantly elevated IL-17RA+ (p = 1.12 x 10-4) or IL-23R+ (p = 1.98 x 10-29) populations compared with the healthy controls. Serum IL-17 levels were significantly lower in SLE patients compared with the healthy controls (p = 8.32 x 10-5), while no significant difference was observed for the IL-23 serum levels between both groups. IL-23R+ Th cells population was significantly associated with higher SLEDAI-2K scores (p = 0.017). In multivariate analysis, the proportion of IL-23R+ Th cells remained significantly associated with higher SLEDAI-2K scores independent of prednisolone intake (p = 0.027). No associations were observed between the interleukin parameters (i.e., IL-17, IL-23, IL-17RA+ Th cells, and IL-23R+ Th cells) with ANA, anti-dsDNA, and CRP status, suggesting that the IL-17/IL-23 axis acts independently of these immunological parameters. In conclusion, our results support that therapeutic inhibition of the IL-23/IL-17 axis receptors on Th cells, particularly IL-23R, is potentially relevant in SLE patients.

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Section: Discussionsupporting

confidence: 89%

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

et al. 2021

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“…So, before the disease, more than half of the patients practiced physical activities, including both sports and walking, however, after the disease onset, only one in four patients performed physical activities. This represents a decrease of almost 30% of patients in this practice and corroborates the results of Kim et al [20], who pointed out that patients with LE are little engaged in physical activities.…”

Section: Discussionsupporting

confidence: 91%

“…Finlay [9] also pointed out that the QoL of patients with skin diseases can be impaired in relation to sports activities due to their skin conditions, because they are also concerned with what other people may think about their appearance. Studies like the one by Kim et al [20] emphasize that patients with LE are little engaged in physical activities. Margiotta et al [21] found that such patients have shown sedentary behavior.…”

Section: Leisure Activities For Patients With Diffuse Connective Tissue Diseasesmentioning

confidence: 97%

Leisure Activities for Patients with Diffuse Connective Tissue Diseases

Nascimento

Velho

Corrêa

et al. 2021

EJMED

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Leisure is everyone right, regardless of the clinical condition of each individual. The quality of life (QoL) of patients with dermatoses has been related to the practice of leisure activities (PLA); however, little is known about this practice in these patients. This study aimed to verify the PLA in patients with Diffuse Connective Tissue Diseases (DCTD). This is a descriptive, qualitative, and quantitative field study with patients seen at the Dermatology Outpatient Clinic (Hospital de Clínicas) of the University of Campinas (UNICAMP), São Paulo, Brazil. A form was used, containing closed questions about the sociodemographic and clinical profiles, and an open question about leisure. The responses were categorized according to the classification of leisure cultural content. Descriptive statistics, construction of a crosstable and the Mann-Whitney and Kruskal-Wallis tests were used. Data from 62 patients were collected, who aged between 19.4 and 75.3 years (average of 49.32±12.55 years). Among the patients, 80.6% were female and 70.9% were diagnosed with Cutaneous or Systemic Lupus Erythematosus (LE). The most practiced leisure activities were those related to manual and virtual content, mentioned by 24.6% of the patients. Another 18.0% reported preferring to stay at home or sleep (other activities), and no patient reported physical-sports or tourist leisure practices. The PLAs were little varied, showing 75.8% of the patients taking only one type of content related to these practices and 12.9% not carrying out any leisure activities. The elderly were the ones who most reported manual and virtual activities. An association was found between the variety of leisure content practiced and literacy level. Illiterate patients were those who least reported activities related to leisure, when compared to those who completed elementary school (X² = 24.686; p= 0.035). Before diagnosis, 56.5% of the patients performed physical activities, of which 27.4% could be classified as physical-sports leisure. After the disease development, only 19.7% of them maintained physical activities, and, of all the activities practiced by them, only 9.7% could be considered as leisure activities, but none as physical-sports leisure. Thus, it appears that leisure practices among patients with DCTD are scarce and little varied, which interferes with their QoL. The orientation and practice of these activities are necessary so that they can make choices and vary the types of activities practiced. Likewise, more studies, which can support actions that encourage and enable the leisure practices of these patients, play an important role.

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“…The medical records of 260 patients who had undergone renal biopsy between August 2005 and August 2018 and were diagnosed with LN were reviewed. From the 260 patients included, this study excluded 53 for the following reasons: (i) Patients who did not fulfil the 1997 revised American College of Rheumatology (ACR) classification criteria for SLE [15,16]; (ii) patients with histopathologic findings incompatible to the criteria proposed by the 2003 International Society of Nephrology/Renal Pathology Society (ISN/RPS) [17,18]; (iii) in LN patients who had undergone repeat renal biopsy, only the result of the first biopsy was used. Finally, a total of 207 patients were included.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis

et al. 2019

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Systemic lupus erythematosus (SLE) is characterized with aberrant responses in the immune systems and lupus nephritis (LN) is one of the most serious complications of SLE. This study evaluated the clinical significance of different nutritional indices in 207 renal biopsy-proven LN patients. The clinical and laboratory data were reviewed, and five different nutritional indices were calculated: (i) Controlling nutritional status (CONUT) score; (ii) prognostic nutritional index (PNI); (iii) nutritional risk index; (iv) neutrophil-to-lymphocyte ratio; and (v) body mass index. The factors associated with end-stage renal failure (ESRF) were assessed using a Cox-proportional hazard analysis. The patients with ESRF had significantly lower median PNI (31.1 vs. 34.7, p = 0.012) than those without ESRF at baseline. The CONUT score and PNI had the highest correlation between the SLE disease activity index-2000 (r = 0.467 and p = −0.356, all p < 0.001) and was significantly associated with SLE activity-related measures. In the Cox-proportional hazard analysis, PNI (odds ratio 0.925, 95% confidence interval 0.865–0.989, p = 0.022) was independently associated with ESRF along with creatinine and chronicity index, and the renal survival rate was significantly lower in patients with PNI ≤35.41 than in those with PNI >35.41 (p = 0.003). Among nutritional indices, the CONUT score and PNI better correlated with disease activity and PNI was associated with ESRF.

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Self-Reported Physical Activity Is Associated with Lupus Nephritis in Systemic Lupus Erythematosus: Data from KORean Lupus Network (KORNET) Registry

Cited by 11 publications

References 38 publications

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Increased IL-23R+ Th Cells Population Exhibits Higher SLEDAI-2K Scores in Systemic Lupus Erythematosus Patients

Leisure Activities for Patients with Diffuse Connective Tissue Diseases

Comparison of the Clinical Implications among Five Different Nutritional Indices in Patients with Lupus Nephritis

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