Self‐reported symptoms and health service use in adolescence in persons who later develop psychotic disorders: A prospective case‐control study

Bratlien, Unni; Øie, Merete Glenne; Haug, Elisabeth; Møller, Paul; Andreassen, Ole A.; Lien, Lars; Melle, Ingrid

doi:10.1111/eip.12102

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Our findings support and extend those of other prospective general population studies. One study 20 also found that anxiety and depression at ages 15 to 16 years were associated with a later psychosis diagnosis. A second study 21 found that social withdrawal and difficulty in contact with others at age 14 years were associated with psychosis diagnosis in early adulthood.…”

Section: Discussionmentioning

confidence: 98%

“…We are aware of 2 studies that have investigated CHR symptoms in general population samples. 20 , 21 Both studies collected symptoms before diagnosis, but the number of outcomes was small, not allowing the discounting of alternative explanations for the findings. A variety of CHR symptoms have been reported as associated with a later diagnosis of psychosis, including unusual thought content, disorganized communication, 15 sleep disturbance, 16 anxiety, depression, feeling in need of treatment for an eating disorder, 20 obsessive-compulsive disorder, 17 social withdrawal, 21 premorbid adjustment, 19 and increasing use of cannabis.…”

Section: Introductionmentioning

confidence: 99%

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Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis

et al. 2018

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Key Points Question Are primary care consultation patterns for prespecified nonspecific symptoms associated with a psychotic diagnosis? Findings In this case-control study of 11 690 adults with psychosis and 81 793 matched controls without psychosis, 12 clinical high-risk symptoms, analyzed by sex and age group, were associated with a psychosis diagnosis, with suicidal behavior having the highest associated risk for psychosis. Pairs of symptoms were associated with an increase in the positive predictive value for a diagnosis of psychosis. Meaning These findings are the first stage in the development and validation of a prognostic model of psychosis for primary care by providing candidate predictors and counter the generally held belief that individuals with emerging psychosis do not seek help from a medical professional.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis

et al. 2018

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“…During 2008 and 2009 a total of 44 patients with schizophrenia spectrum disorders were coming to their first adequate treatment (i.e., not having previously received adequate antipsychotic medication in adequate doses for 12 weeks, or until remission); some had not initiated treatment at first evaluation. To enhance statistical power we additionally included 11 patients enrolled in a related study of young patients with psychosis born in 1985/86 (Bratlien et al, 2014, 2015). They were in the early phases of treatment, with an even shorter DUP than the strict first treatment patients, and met the same inclusion and exclusion criteria, except for the strict definition of first treatment.…”

Section: Methodsmentioning

confidence: 99%

The Association between Anomalous Self-experiences, Self-esteem and Depressive Symptoms in First Episode Schizophrenia

Haug

Øie

Andreassen

et al. 2016

Front. Hum. Neurosci.

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Background: Anomalous self-experiences (ASEs) aggregate in schizophrenia spectrum disorders, but the relationship between ASEs, and depression has been studied to a limited extent. Lower self-esteem has been shown to be associated with depression in early psychosis. Our hypothesis is that ASEs in early phases of schizophrenia are linked to lower levels of self-esteem, which in turn is associated with depression.Aim: The aim is to examine the relationship between ASEs, self-esteem and depression in first-episode schizophrenia spectrum disorders.Method: ASEs were assessed in 55 patients with first-episode schizophrenia by means of the Examination of anomalous Self-Experience (EASE) instrument. Assessment of depression was based on the Calgary Depression Scale for Schizophrenia (CDSS). Self-esteem was measured using the Rosenberg Self-Esteem Scale (RSES). Symptom severity was assessed using the Structured Clinical Interview for the Positive and Negative Syndrome Scale (SCI-PANSS). Substance misuse was measured with the Drug Use Disorder Identification Test (DUDIT), and alcohol use was measured with the Alcohol Use Disorder Identification Test (AUDIT). Data on childhood adjustment were collected using the Premorbid Adjustment Scale (PAS). Data on childhood trauma were collected using the Norwegian version of the Childhood Trauma Questionnaire, short form (CTQ-SF).Results: Analyses detected a significant association between current depression and ASEs as measured by the EASE in women, but not in men. The effect of ASEs on depression appeared to be mediated by self-esteem. No other characteristics associated with depression influenced the relationship between depression, self-esteem and ASEs.Conclusion: Evaluating ASEs can assist clinicians in understanding patients' experience of self-esteem and depressive symptoms. The complex interaction between ASEs, self-esteem, depression and suicidality could be a clinical target for the prevention of suicidality in this patient group.

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“…The sample includes all consecutively identified first‐episode patients from all participating health services in the two counties. For the purpose of the current analyses, we additionally included 11 patients enrolled in a related study of young patients with psychosis born in 1985/1986 . They were in the early phases of treatment and met the same inclusion and exclusion criteria, except for the strict definition of first treatment.…”

Section: Methodsmentioning

confidence: 99%

High levels of anomalous self‐experience are associated with longer duration of untreated psychosis

Haug

Øie

Andreassen

et al. 2015

Early Intervention Psych

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Self‐reported symptoms and health service use in adolescence in persons who later develop psychotic disorders: A prospective case‐control study

Abstract: We found that, in comparison with others, youths who were later identified with a psychotic disorder reported more symptoms at age 16.

Cited by 9 publications

References 33 publications

Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis

Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis

The Association between Anomalous Self-experiences, Self-esteem and Depressive Symptoms in First Episode Schizophrenia

High levels of anomalous self‐experience are associated with longer duration of untreated psychosis

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