Self‐Reporting Liposomes for Intracellular Drug Release

Chen, Wansong; Huang, Qiyu; Ou, Weizhu; Hao, Yuanqiang; Wang, Liqiang; Zeng, Ke; Guo, Hongyan; Li, Juan; Liu, You‐Nian

doi:10.1002/smll.201302698

Cited by 41 publications

(31 citation statements)

References 43 publications

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“…Stimuli-triggered delivery of anticancer drugs [1–3] is mainly focused on the applications of the tumor microenvironmental or cellular physiological characteristics including higher temperature [4–5], lower pH [6–8], higher redox potential [9–11], enzyme overexpression [12–13] and higher level of reactive oxygen species [14–15] to promote the release of drugs at the target site for cancer treatment. Numerous nanocarriers integrating with the responsive elements, such as liposomes, polymeric nanoparticles, protein/DNA nanostructures and inorganic nanovehicles, have been widely exploited to achieve controlled release of their cargoes within the tumor tissues or cells [16–22].…”

Section: Introductionmentioning

confidence: 99%

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

et al. 2015

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Stimuli-triggered drug delivery systems are primarily focused on the applications of the tumor microenvironmental or cellular physiological cues to enhance the release of drugs at the target site. In this study, we applied adenosine-5′-triphosphate (ATP), the primary “energy molecule”, as a trigger for enhanced release of preloaded drugs responding to the intracellular ATP concentration that is significantly higher than the extracellular level. A new ATP-responsive anticancer drug delivery strategy utilizing DNA-graphene crosslinked hybrid nanoaggregates as carriers was developed for controlled release of doxorubicin (DOX), which consists of graphene oxide (GO), two single-stranded DNA (ssDNA, denoted as DNA1 and DNA2) and ATP aptamer. The single-stranded DNA1 and DNA2 together with the ATP aptamer serve as the linkers upon hybridization for controlled assembly of the DNA-GO nanoaggregates, which effectively inhibited the release of DOX from the GO nanosheets. In the presence of ATP, the responsive formation of the ATP/ATP aptamer complex causes the dissociation of the aggregates, which promoted the release of DOX in the environment with a high ATP concentration such as cytosol compared with that in the ATP-deficient extracellular fluid. This supports the development of a novel ATP-responsive platform for targeted on-demand delivery of anticancer drugs inside specific cells.

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Section: Introductionmentioning

confidence: 99%

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

et al. 2015

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“…It has been recognized that tumor cells are abundant with GSH to protect them from ROS damage . We supposed that Cu 2− x Te NEs with GSHOx‐ and POD‐mimicking activities could deplete intracellular GSH and generate ROS concurrently, which would synergistically elevate intratumor oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

et al. 2019

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Current cancer therapy is seriously challenged by tumor metastasis and recurrence. One promising solution to these problems is to build antitumor immunity. However, immunotherapeutic efficacy is highly impeded by the immunosuppressive state of the tumors. Here a new strategy is presented, catalytic immunotherapy based on artificial enzymes. Cu2−xTe nanoparticles exhibit tunable enzyme‐mimicking activity (including glutathione oxidase and peroxidase) under near‐infrared‐II (NIR‐II) light. The cascade reactions catalyzed by the Cu2−xTe artificial enzyme gradually elevates intratumor oxidative stress to induce immunogenic cell death. Meanwhile, the continuously generated oxidative stress by the Cu2−xTe artificial enzyme reverses the immunosuppressive tumor microenvironment, and boosts antitumor immune responses to eradicate both primary and distant metastatic tumors. Moreover, immunological memory effect is successfully acquired after treatment with the Cu2−xTe artificial enzyme to suppress tumor relapse.

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“…28,29 It has been discussed before that the improved drug release rate under lower pH values would be desirable in tumor therapy. 29,30 Here the capability of tunable drug delivery of AIE based carriers has been demonstrated by the activation of the prodrug via the pHdependent process.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Aggregation Induced Emission Mediated Controlled Release by Using a Built-In Functionalized Nanocluster with Theranostic Features

et al. 2015

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We report biological evaluation of a novel nanoparticle delivery system based on 1,1,2-triphenyl-2-(p-hydroxyphenyl)-ethene (TPE-OH, compound 1), which has tunable aggregation-induced emission (AIE) characteristics. Compound 1 exhibited no emission in DMSO. In aqueous media, compound 1 aggregated, and luminescence was observed. The novel membrane-cytoplasm-nucleus sequential delivery strategy could induce apoptosis in four different kinds of cancer cells (including three adherent cell lines and one suspension cell line). The nanoparticles remained in the cytoplasm with intense blue emissions, whereas doxorubicin was observed in the nucleus with striking red luminescence. The nanoassembly was internalized in cells through an energy-dependent process. Three sorts of chemical inhibitors were used to clarify the endocytosis mechanism based on the AIE type prodrug. Furthermore, we have developed the first AIE theranostic system where drug targeting and release have been applied in an animal model.

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Self‐Reporting Liposomes for Intracellular Drug Release

Cited by 41 publications

References 43 publications

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

Artificial Enzyme Catalyzed Cascade Reactions: Antitumor Immunotherapy Reinforced by NIR‐II Light

Aggregation Induced Emission Mediated Controlled Release by Using a Built-In Functionalized Nanocluster with Theranostic Features

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