Self-selected unrefined and refined carbohydrate diets do not affect metabolic control in pump-treated diabetic patients

Venhaus, A; Chantelau, Ernst

doi:10.1007/bf00276848

Cited by 19 publications

(2 citation statements)

References 29 publications

(32 reference statements)

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“…Patients were asked to keep their body weight constant. At the end of the run-in period, at the end of the dietary training period and at the end of the 4-week blinded study period, patients completed a 3-day food diary as described elsewhere [21]. During the last day of these 3 days, patients collected a 24-h urine sampie.…”

Section: Methodsmentioning

confidence: 99%

Effects of dietary sodium on blood pressure in IDDM patients with nephropathy

et al. 1996

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The objectives of the study were to assess the effects of moderate sodium restriction on blood pressure in insulin-dependent diabetic (IDDM) patients with nephropathy and high normal or mildly hypertensive blood pressure (primary objective), and to document possible associated changes of exchangeable body sodium, body volumes, components of the renin-angiotensin-aldosterone system, atrial natriuretic peptide, and catecholamines (secondary objective). Sixteen patients with untreated systolic blood pressure > or = 140 < 160 mmHg and/or diastolic blood pressure > or = 85 < 100 mmHg were included in a double-blind, randomized, placebo-controlled trial. After a 4-week run-in period on their usual diet and a 2-week dietary training period to reduce sodium intake to about 90 mmol/day, eight patients received 100 mmol/day sodium supplement (group 2) and eight patients a matching placebo (group 1) for 4 weeks while continuing on the reduced-sodium diet. Patients were examined at weekly intervals. Main response variables were mean values of supine and sitting systolic and diastolic blood pressure as measured in the clinic and by the patients at home. The differences in blood pressure between the beginning and the end of the blinded 4-week study period were calculated and the differences in changes between the two patient groups were regarded as the main outcome parameters. During the blinded 4-week study period, average urinary sodium excretion was 92 +/- 33 (mean +/- SD) mmol/day in group 1 and 199 +/- 52 mmol/day in group 2 (p = 0.0002). The differences in blood pressure changes between the two patient groups were 3.9(-1.2 to 9) mmHg [mean (95% confidence intervals)] for systolic home blood pressure, 0.9(-3.7 to 5.5) mmHg for diastolic home blood pressure, 4.9(-3.3 to 13.1) mmHg for clinic systolic blood pressure and 5.3(1 to 9.7 mmHg, p = 0.02) for clinic diastolic blood pressure. Combining all patients, there were relevant associations between changes of urinary sodium excretion and blood volume (Spearman correlation coefficient r = 0.57), blood pressure and angiotensin II (diastolic: r = -0.7; systolic: r = -0.48), and exchangeable body sodium and renin activity (r = -0.5). In conclusion, in this study of IDDM patients with nephropathy and high normal or mildly hypertensive blood pressure, a difference in sodium intake of about 100 mmol/day for a period of 4 weeks led to a slight reduction of clinic diastolic blood pressure. Studies including larger numbers of patients with various stages of nephropathy and hypertension are needed to definitely clarify the effects of sodium restriction in IDDM.

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Section: Methodsmentioning

confidence: 99%

Effects of dietary sodium on blood pressure in IDDM patients with nephropathy

et al. 1996

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“…It has been shown repeatedly that in patients with adequate preprandial insulin therapy the inclusion of sucrose in a mixed meal does not lead to a significant postprandial hyperglycemia [20, 21, 22, 23]. Even regular use of up to 40 g sucrose/day in the nutrition of intensively treated IDDM patients had no negative effect on metabolic control [24, 25, 26, 27]. …”

Section: Diabetes Dietmentioning

confidence: 99%

Non-Evidence-Based Concepts Are Still Established in the Treatment of IDDM

Heise

Berger²,

Sawicki³

1998

Horm Res Paediatr

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Medicine is and always has been full of unproven concepts. However, when they are frequently used in clinical practice, they seem established and are therefore seldom questioned. In his book ‘Follies and fallacies in medicine’ (Glasgow, The Tarragon Press, 1989) Peter Skrabanek clearly proposed a way to improve the quality of medicine by being chronically sceptical towards all ‘established’ concepts. By cyting Bertold Brecht he proposed ‘scepticemia’ as a major tool to speed up the progress in medicine: ‘The chief cause of poverty in science is imaginary wealth. The chief aim of science is not to open a door to infinite wisdom but to set a limit to infinite error.’ In this article we will try to analyze the evidence of the three so-called cornerstones of diabetes therapy – diet, exercise and insulin – with regard to their efficacy in reaching the goals of treatment in type 1 (insulin-dependent) diabetes.

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Dietary Fibre in the Prevention and Treatment of Diabetes Mellitus

Berger¹,

Venhaus²

1992

Dietary Fibre — A Component of Food

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Self-selected unrefined and refined carbohydrate diets do not affect metabolic control in pump-treated diabetic patients

Cited by 19 publications

References 29 publications

Effects of dietary sodium on blood pressure in IDDM patients with nephropathy

Effects of dietary sodium on blood pressure in IDDM patients with nephropathy

Non-Evidence-Based Concepts Are Still Established in the Treatment of IDDM

Dietary Fibre in the Prevention and Treatment of Diabetes Mellitus

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