In this paper, we present a unifying analytical framework for identifying conditions for transport effects such as reflectionless and transparent transport, lasing, and coherent perfect absorption in non-Hermitian nonreciprocal systems using a generalized transfer matrix method. This provides a universal approach to studying the transport of tight-binding platforms, including higherdimensional models and those with an internal degree of freedom going beyond the previously studied case of one-dimensional chains with nearest-neighbor couplings. For a specific class of tight-binding models, the relevant transport conditions and their signatures of non-Hermitian, nonreciprocal, and topological behavior are analytically tractable from a general perspective. We investigate this class and illustrate our formalism in a paradigmatic ladder model where the system's parameters can be tuned to adjust the transport effect and topological phases.