Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy

Li, Junjie; Ke, Wei; Wang, Lei; Huang, Mingming; Yin, Wei; Zhang, Ping; Chen, Qixian; Ge, Zhishen

doi:10.1016/j.jconrel.2016.01.029

Cited by 118 publications

(93 citation statements)

References 61 publications

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“…After 24 hp ost intravenous injection of theraNR, 6'-o-pentafluorobenzene sulfonyl-2',7'-difluorofluorescein (BES-H 2 O 2 )solution was injected into the tail vein and the green fluorescence intensity in tumor was detected using dorsal window chamber models due to the fluorescence turn-on after treatment by H 2 O 2 . [15] Thefluorescence intensity increased afactor of four quickly in tumor tissue compared with the PBS,G OD,a nd NC groups indicating significantly improved H 2 O 2 level in tumor after treatment by theraNR ( Figure 3B…”

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confidence: 92%

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation

Dirisala

et al. 2017

Angewandte Chemie

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Polymeric nanoreactors (NRs) have distinct advantages to improve chemical reaction efficiency,b ut the in vivo applications are limited by lack of tissue-specificity.H erein, novel glucose oxidase (GOD)-loaded therapeutic vesicular NRs (theraNR) are constructed based on adiblockcopolymer containing poly(ethylene glycol) (PEG) and copolymerized phenylboronic ester or piperidine-functionalized methacrylate (P(PBEM-co-PEM)). Upon systemic injection, theraNR are inactive in normal tissues.A tatumor site,t heraNR are specifically activated by the tumor acidity via improved permeability of the membranes.H ydrogen peroxide (H 2 O 2 ) production by the catalysis of GOD in theraNR increases tumor oxidative stress significantly.M eanwhile,h igh levels of H 2 O 2 induce self-destruction of theraNR releasing quinone methide (QM) to deplete glutathione and suppress the antioxidant ability of cancer cells.F inally,t heraNR efficiently kill cancer cells and ablate tumors via the synergistic effect.

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confidence: 92%

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation

Dirisala

et al. 2017

Angewandte Chemie

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“…More recently, several investigations using multifunctional stimulus-responsive drug delivery systems (or nanoreactors) were published. 98 , 99 These systems aim to specifically upregulate stimuli inside the physical environment of the tumor to create an amplified intratumoral stimulus compared to the healthy tissue. This will eventually lead to a release of active drug from the multifunctional stimulus-responsive drug delivery system and therefore intratumoral accumulation of the anticancer drugs.…”

Section: Discussionmentioning

confidence: 99%

Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer

Eerden

Mathijssen

Koolen

2020

IJN

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“…On one hand, pH-dependent charge conversion strategy is utilized to construct polymeric drug, which maintains their stealth features during circulation and then undergoes a charge reversal process for achieving enhanced tumor cells' internalization once exposed to tumor relative acidic environment [15][16][17][18] . On the other hand, polymeric drug with ROS generation capability will be an effective approach to copying with insu cient ROS concentration for activating the complete drug release [13][14][15]19] .…”

Section: Introductionmentioning

confidence: 99%

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

Zhang

Zhu

Miao

et al. 2020

Preprint

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Background: The enhancement of tumor retention and cellular uptake of drugs are important factors in maximizing anticancer therapy and minimizing side effects of encapsulated drugs. Herein, a delivery nanoplatform, armed with a pH-triggered charge-reversal capability and self-amplifiable reactive oxygen species (ROS)-induced drug release, is constructed by encapsulating doxorubicin (DOX) in pH/ROS-responsive polymeric micelle. Results: The surface charge of this system was converted from negative to positive from pH 7.4 to pH 6.8, which facilitated the cellular uptake. In addition, methionine-based system was dissociated in a ROS-rich and acidic intracellular environment, resulting in the release of DOX and α-tocopheryl succinate (TOS). Then, the exposed TOS segments further induced the generation of ROS, leading to self-amplifiable disassembly of the micelles and drug release. Conclusions: We confirms efficient DOX delivery into cancer cells, upregulation of tumoral ROS level and induction of the apoptotic capability in vitro . The system exhibits outstanding tumor inhibition capability in vivo , indicating that dual stimuli nano-system has great potential to function as an anticancer drug delivery platform.

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Self-sufficing H2O2-responsive nanocarriers through tumor-specific H2O2 production for synergistic oxidation-chemotherapy

Cited by 118 publications

References 61 publications

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation

Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation

Recent Clinical Developments of Nanomediated Drug Delivery Systems of Taxanes for the Treatment of Cancer

Dual-responsive doxorubicin-loaded nanomicelles for enhanced cancer therapy

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