“…However, a simple similarity measure with a pre-set threshold is insufficient to assign high-confident protein function. DL-based PFP methods include function prediction from AA-sequence (Rao et al, 2019;Alley et al, 2019;Elnaggar et al, 2020;Dallago et al, 2021;Kulmanov & Hoehndorf, 2020;Meier et al, 2021;Biswas et al, 2021;Gelman et al, 2021;Yang et al, 2022a), 3-dimensional structure (GligorijeviÄ et al, 2021;Smaili et al, 2021;Guo et al, 2022), evolutionary relationships and genomic context (Rao et al, 2021;Engelhardt et al, 2005), and their combinations GligorijeviÄ et al, 2021). Here, we mainly restrict our scope to the sequence and structure.…”