Self‐Supported and Clean One‐Step Cathodic Coupling of Activated Olefins with Benzyl Bromide Derivatives in a Micro Flow Reactor

Abstract

Currently coupled: A clean microreactor‐based electrosyntheses in the absence of supporting electrolyte is demonstrated and shown to feature very simple cell geometries. As exemplified for the coupling reaction of various olefins with benzyl bromides, the height of the microfluidic cell and the flow rate are crucial for the minimization of unwanted side products and optimization of yields (see picture).

Anionic polymerization of alkyl methacrylates using flow microreactor systems

“…Therefore, short residence time in flow microreactor systems also seems to be responsible for preventing decomposition of the reactive polymer chain end. The Mw/Mn of the polymer obtained at −48 and −78 • C was also large presumably because of slow initiation (entries [10][11][12][13]. These results show that precise control of the reaction temperature is very important to control the molecular-weight distribution in the flow microreactor system.…”

“…Chemical synthesis in flow microreactor systems has received significant research interests from both academia and industry [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Recent investigations revealed significant features of flow microreactor systems involving fast mixing stemming from short diffusion path and fast heat transfer by virtue of high surface-tovolume ratio, which are advantageous to increase the selectivity of chemical reactions [17][18][19].…”

Electrochemical microfluidics

“…This results in a complex molecular exchange that can enhance reactivity and selectivity. He et al (2006) demonstrate such coupling with one-step cathodic coupling of activated olefins with benzylbromide derivatives.…”

Microreactor Technology in Lithium Chemistry

“…Short residence time in a microchannel is beneficial for controlling highly reactive and unstable intermediates. By taking advantage of such features of flow microreactors, various reactions for organic synthesis and polymer synthesis have been developed [25][26][27][28][29][30][31][32][33].…”