Self-sustainable intermittent deep brain stimulator

Elsanadidy, Esraa; Mosa, Islam M.; Hou, Bowen; Schmid, Tobias; El‐Kady, Maher F.; Khan, Raihan Sayeed; Haeberlin, Andreas; Tzingounis, Anastasios V.; Rusling, James F.

doi:10.1016/j.xcrp.2022.101099

Cited by 9 publications

(7 citation statements)

References 33 publications

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“…Elsanadidy et al recently reported a self-sustainable neurostimulation system that uses TENG in a way that overcome the energy gap limitation. [61] In this work, a self-sustainable and intermittent deep brain stimulator was developed (Figure 7). This smart deep brain stimulator system has three main components, a bio-triboelectric nanogenerator (Bio-TENG) to harvest the mechanical energy of the breathing motion (Figure 7A), and biosupercapacitor as an energy storage, and a pulse generator that produces a highly regulated pulses to the brain with the desired frequency and pulse width (Figure 7B).…”

Section: Self-powered Intermittent Neuromodulationmentioning

confidence: 99%

“…A recently trending self‐sustainable intermittent neurostimulation approach has been proposed to close the gap between the relatively low energy generation from biomechanical motion of body organs and the high energy demands of implantable neurostimulators ( Figure ). [ 61 ] Although TENG devices have many advantages as implantable energy harvesters, they are still limited because TENGs produce alternating power (not continuous). In addition, TENGs produce relatively low power output due to the weak mechanical impact of body organs with TENG.…”

Section: Self‐powered Intermittent Neuromodulationmentioning

confidence: 99%

“…This work opens a new avenue for discovering self‐powered and intermittent neurostimulation for central and peripheral nervous system where a short period or intermittent stimulation is sufficient to obtain a therapeutic response. [ 61 ]…”

Section: Self‐powered Intermittent Neuromodulationmentioning

confidence: 99%

“…The electrical signal was generated through the Bio-TENG. Reproduced with permission [61]. Copyright Cell Press 2022.…”

mentioning

confidence: 99%

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Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Elsanadidy

Mosa

Luo

et al. 2023

Adv Funct Materials

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Advances in implantable bioelectronics for the nervous system are reinventing the stimulation, inhibition, and sensing of neuronal activity. These efforts promise not just breakthrough treatments of several neurological and psychiatric conditions but also signal the beginning of a new era of computer‐controlled human therapeutics. Batteries remain the major power source for all implanted electrical neuromodulation devices, which impairs miniaturization and necessitates replacement surgery when the battery is drained. Triboelectric nanogenerators (TENGs) have recently emerged as an innovative power solution for self‐powered, closed loop electrical neurostimulation devices. TENGs can leverage the biomechanical activities of different body organs to sustainably generate electricity for electrical neurostimulation. This review features advances in TENGs as they pave the way for self‐sustainable closed loop neurostimulation. A comprehensive review of TENG research for the neurostimulation of brain, autonomic, and somatic nervous systems is provided. The direction of growth of this field, publication trends, and modes of TENG in implantable bioelectronics are also discussed. Finally, an insightful outlook into challenges facing self‐sustainable neuromodulators to reach clinical practice is provided, and solutions for neurological maladies are proposed.

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Section: Self-powered Intermittent Neuromodulationmentioning

confidence: 99%

Section: Self‐powered Intermittent Neuromodulationmentioning

confidence: 99%

Section: Self‐powered Intermittent Neuromodulationmentioning

confidence: 99%

“…The electrical signal was generated through the Bio-TENG. Reproduced with permission [61]. Copyright Cell Press 2022.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Advances in Triboelectric Nanogenerators for Self‐powered Neuromodulation

Elsanadidy

Mosa

Luo

et al. 2023

Adv Funct Materials

Self Cite

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“…[38] Elsanadidy et al presented a deep brain stimulator designed to harness breathing energy, storing it efficiently through a substantial capacitor, and ultimately generating a pulse signal. [39] When dealing with stimuli demanding a consistent pulse, it's advisable to employ an ultracapacitor for energy storage. This stored energy can subsequently power the pulse-generating circuit.…”

Section: Introductionmentioning

confidence: 99%

Wireless Battery‐Free Peripheral Nerve Stimulation Conch for Remote Muscle Activation

Zhang,

Yang,

Long

et al. 2023

Adv Materials Technologies

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Peripheral nerve stimulators have emerged as a crucial instrument in the realm of neurological disease, capable of modulating nerve activity through precisely targeted electrical stimulation to specific sites within the nervous system. Here, a new wireless battery‐free peripheral nerve stimulation device for remote muscle activation is developed. The device with conch‐inspired bionic design can be wirelessly powered and controlled by a mobile phone playing audio via the piezoelectric effect. The device consists of two parts: a conch‐like signal‐intensifying piezoelectric resonator for converting acoustic wave into electrostimulation signal; and a pedestal with stimulation electrodes for transmitting the electrostimulation signal to a peripheral nerve. For remote nerve intervention, a programmed audio tone from one mobile phone can be tele‐transmitted from other phones according to the desired stimulation protocols. In‐vivo experiments in stimulating the sciatic nerve in mice showed that the device can activate muscles (e.g., 1 Hz 920 mV for 26 degree of leg movement), and the neuron‐muscle interaction has been confirmed by electromyogram (EMG). The wireless peripheral nerve stimulation conch achieves feasible remote muscle activation without batteries, and can extend the scope of self‐powered techniques for telemedicine and limb/trunk rehabilitation.

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