2023
DOI: 10.1016/j.colsurfb.2023.113467
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Self-template synthesis of mesoporous and biodegradable Fe3O4 nanospheres as multifunctional nanoplatform for cancer therapy

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Cited by 6 publications
(7 citation statements)
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“…By templating mesoporous Fe 3 O 4 microspheres, PRD layers were then coated on their mesopores through the above in situ polymerization with optimal ethanol/water ratio. Here, the mesoporous Fe 3 O 4 microspheres with a diameter of 450 nm were first synthesized by simply treating Fe 3 O 4 microspheres in oxalic acid solution, and then the smaller Fe 3 O 4 nanocrystals in the microsphere could be dissolved preferentially, the left spiky mesoporous skeleton was composed of the nanocrystals with orientated attachment. ,, As shown in Figure a,b, hierarchical topography could be observed on the surface of the Fe 3 O 4 microspheres. Meanwhile, a mesoporous structure was also found in the interior of Fe 3 O 4 microspheres (Figure c,d).…”
Section: Results and Discussionmentioning
confidence: 99%
“…By templating mesoporous Fe 3 O 4 microspheres, PRD layers were then coated on their mesopores through the above in situ polymerization with optimal ethanol/water ratio. Here, the mesoporous Fe 3 O 4 microspheres with a diameter of 450 nm were first synthesized by simply treating Fe 3 O 4 microspheres in oxalic acid solution, and then the smaller Fe 3 O 4 nanocrystals in the microsphere could be dissolved preferentially, the left spiky mesoporous skeleton was composed of the nanocrystals with orientated attachment. ,, As shown in Figure a,b, hierarchical topography could be observed on the surface of the Fe 3 O 4 microspheres. Meanwhile, a mesoporous structure was also found in the interior of Fe 3 O 4 microspheres (Figure c,d).…”
Section: Results and Discussionmentioning
confidence: 99%
“…Unlike the large diameter of the others mesoporous SPION [ 14 ], the as-prepared MSPION possess only ∼70 nm size, which is favor for its long circulation in vivo. Unlike the two-step acid etching processes used in obtaining mesoporous structures [ 16 ], the as-prepared MSPION was synthesized by a single step, where the reaction temperature and time are easily controlled. Unlike other systems that involve the addition of surfactants (such as CTAB) for the synthesis of SPIONs [ 17 ], the as-prepared MSPION was prepared without the use of any surfactants, which eliminates the potential toxicity and adverse reactions associated with surfactants.…”
Section: Resultsmentioning
confidence: 99%
“…There have been efforts to develop mesoporous SPION (MSPION) to overcome this limitation. The potential applications of these developed mesoporous SPION for drug loading are limited by their large particle size [ 14 ] complicated synthesis process [ 16 ], and use of unfriendly surfactants [ 17 ]. In this study, we addressed several critical issues.…”
Section: Discussionmentioning
confidence: 99%
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“…The development of MNPs, including IONPs, has proposed a promising functional platform that displays the capability to detect tumor metastasis early. As a helpful platform, these MNPs could also carry several different ligands for cancer imaging and treatment [ 109 ]. The incorporation of multiple components into magnetic nanomaterials allows the delivery of cargo to manage disease progression sensitively.…”
Section: Implications and Future Directionsmentioning
confidence: 99%