“…As a result of this classification, from a range of possible algorithms: implicit Generalized minimum variance (Clarke and Gawthrop 1979), explicit polynomial pole placement self tuning (Wellstead et al 1979(Wellstead et al , 1981, explicit state space pole placement self tuning (Warwick, 1981), sub-optimal iterative solution of the discrete Riccati equation to produce an explicit LQG control law, and the explicit Generalized Predictive Controller (Clarke et al, 1985), only the last two techniques were found to be amenable to application on the fed-batch fermentation process being studied. In this process accurate tracking of a time varying biomass set point profile is essential, with an absolute minimum of overshoot or oscillation; both of which are detrimental to high penicillin yields.…”