Differential drive mobile robots, being widely used in several industrial and domestic applications, are increasingly demanding when concerning precision and satisfactory maneuverability. In the present paper, the problem of independently controlling the velocity and orientation angle of a differential drive mobile robot is investigated by developing an appropriate two stage nonlinear controller embedded on board and also by using the measurements of the speed and accelerator of the two wheels, as well as taking remote measurements of the orientation angle and its rate. The model of the system is presented in a nonlinear state space form that includes unknown additive terms arising from external disturbances and actuator faults. Based on the nonlinear model of the system, the respective I/O relation is derived, and a two-stage nonlinear measurable output feedback controller, analyzed into an internal and an external controller, is designed. The internal controller aims to produce a decoupled inner closed-loop system of linear form, regulating the linear velocity and angular velocity of the mobile robot independently. The internal controller is of the nonlinear PD type and uses real time measurements of the angular velocities of the active wheels of the vehicle, as well as the respective accelerations. The external controller aims toward the regulation of the orientation angle of the vehicle. It is of a linear, delayed PD feedback form, offering feedback from the remote measurements of the orientation angle and angular velocity of the vehicle, which are transmitted to the controller through a wireless network. Analytic formulae are derived for the parameters of the external controller to ensure the stability of the closed-loop system, even in the presence of the wireless transmission delays, as well as asymptotic command following for the orientation angle. To compensate for measurement noise, external disturbances, and actuator faults, a metaheuristic algorithm is proposed to evaluate the remaining free controller parameters. The performance of the proposed control scheme is evaluated through a series of computational experiments, demonstrating satisfactory behavior.