Sellar and parasellar lesions – Clinical outcome in 61 children

Unsinn, Caroline; Neidert, Marian C.; Burkhardt, Jan‐Karl; Holzmann, David; Grotzer, Michael A.; Bozinov, Oliver

doi:10.1016/j.clineuro.2014.04.026

Cited by 13 publications

(8 citation statements)

References 32 publications

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“…10 A retrospective evaluation of 61 children with sellar or parasellar lesions who underwent neurosurgical procedures found that the majority had no change in vision (58.3%), and 10% had an improvement in vision, but 25% had worsening of vision. 11 Four patients (6.7%) had complete vision loss in one eye, eight (13.3%) developed new visual field defects. 11 Pineal tumors can lead to vision loss as well, and a retrospective chart review of 20 children describing optic atrophy in 5%, and homonymous hemianopia in 5%.…”

Section: Effects On Afferent Visual Systemmentioning

confidence: 97%

Visual function in children with primary brain tumors

Peragallo

2019

Current Opinion in Neurology

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Purpose of review: To review the recent advances in understanding how primary brain tumors affect vision in children. Recent findings: Children with primary brain tumors may have vision loss due to involvement of their afferent visual pathways or from papilledema. These vision deficits may go unrecognized until later in life, years after treatment of the primary lesion. Strabismus and cranial nerve palsies may occur as a result of brain tumors. Ophthalmologists can monitor and treat young children at risk for vision loss from amblyopia as a result of effects from their underlying lesion. Advances in imaging techniques have made it possible to quantify damage to the visual pathways with objective tests. Summary: Systematic referrals for evaluation by an ophthalmologist should occur early in the course of treatment of primary brain tumors as these evaluations may improve visual outcomes and quality of life.

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Section: Effects On Afferent Visual Systemmentioning

confidence: 97%

Visual function in children with primary brain tumors

Peragallo

2019

Current Opinion in Neurology

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“…Traditionally, the first step in management after imaging is surgical biopsy. Surgical intervention in the optic pathway, sellar, and suprasellar region is technically challenging, with a significant risk of morbidity . Tumors in this region vary greatly in their chemotherapeutic regimens and radiotherapy, so correct diagnosis is crucial.…”

Section: Introductionmentioning

confidence: 99%

“…Surgical intervention in the optic pathway, sellar, and suprasellar region is technically challenging, with a significant risk of morbidity. [6][7][8] Tumors in this region vary greatly in their chemotherapeutic regimens and radiotherapy, so correct diagnosis is crucial. Accurate preoperative interpretation in lesions that are high Abbreviations: GCT, germ cell tumor; LCH, Langerhans cell histiocytosis; OPG, optic pathway glioma risk for surgical intervention could reduce morbidity and mortality associated with these procedures.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of neuroimaging in pediatric optic chiasm/sellar/suprasellar tumors

Norris

García

Hankinson

et al. 2019

Pediatric Blood & Cancer

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Preoperative diagnosis for tumors arising in the optic chiasm/sellar/suprasellar region in children is helpful to determine surgical necessity and approach, given the high operative risk in this area. We evaluated the ability to differentiate tumor type by preoperative neuroimaging. Thirty‐eight of 53 tumors were correctly diagnosed by neuroimaging based on final pathologic diagnosis (prediction accuracy 72%). Prediction accuracies were 87% (20/23) for craniopharyngioma, 79% (11/14) for optic pathway glioma, 64% (7/11) for germ cell tumor, and 0% (0/5) for Langerhans cell histiocytosis. Diagnosis of optic chiasm/sellar/suprasellar tumors in children by imaging alone should be considered when biopsy is considered high risk.

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“…Pituitary adenomas are some of the most frequent intracranial tumors [ 1 ], being the most common tumors of the sellar region. Sometimes, their unusual clinical behavior at different ages [ 2 , 3 ] and hormone immunoprofile heterogeneity [ 4 ] make the establishment of a proper diagnosis and appropriate therapeutic options difficult. Pituitary adenoma heterogeneity was also stated at genetic level [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Geographic-Related Differences of Pituitary Adenomas Hormone Profile: Analysis of Two Groups Coming from Southeastern and Eastern Europe

Cimpean

Melnic

Balinisteanu

et al. 2015

International Journal of Endocrinology

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We compared the immunoprofile of pituitary adenomas from Romania and Moldova. One hundred and eighty cases coming from Romania (94 cases, group 1) and Moldova (86 cases, group 2) were assessed by immunohistochemistry regarding all six basic hormones expressed in pituitary adenomas. Specific differences and similarities were found and stated for both groups. In group 1, 70% of cases were pituitary adenomas positive for one hormone, 13% were plurihormonal, while 17% were negative. In group 2, 50,3% of the cases expressed only one hormone and 12,5% were negative for all hormones. The highest difference was observed for plurihormonal adenomas, found in about 37,2% of cases for group 2 (2.86 times higher for group 2 compared with group 1). A higher incidence of GH-secreting adenomas characterized group “1,” while group “2” had the highest percent of LH-secreting adenomas, 55% of cases being positive. Triple association was noticed in 4.25% of cases of group 1 and in 8,13% out of total cases, from group 2. Four-hormone association was found only in group 2, noticed in 15,56% of the cases. The present paper highlights strong evidences of a particular and different immunoprofile of pituitary adenomas coming from Romania and Moldova.

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Sellar and parasellar lesions – Clinical outcome in 61 children

Cited by 13 publications

References 32 publications

Visual function in children with primary brain tumors

Visual function in children with primary brain tumors

Diagnostic accuracy of neuroimaging in pediatric optic chiasm/sellar/suprasellar tumors

Geographic-Related Differences of Pituitary Adenomas Hormone Profile: Analysis of Two Groups Coming from Southeastern and Eastern Europe

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