We explore genetic and neurological bases for customer orientation (CO) and contrast them with sales orientation (SO). Study 1 is a field study that establishes that CO, but not SO, leads to greater opportunity recognition. Study 2 examines genetic bases for CO and finds that salespeople with CO are more likely to have the 7R variant of the DRD4 gene. This is consistent with basic research on dopamine receptor activity in the brain that underlies novelty seeking, the reward function, and risk taking. Study 3 examines the neural basis of CO and finds that salespeople with CO, but not SO, experience greater activation of their mirror neuron systems and neural processes associated with empathy. Managerial and research implications are discussed.Keywords Knowledge brokering . Opportunity recognition . Genetics . Customer orientation . Neuroscience . Biomarkers . Personal selling . Marketing concept "Everybody hates their phone," Jobs says, "and that is not a good thing. And there's an opportunity there." To Jobs' perfectionist eyes, phones are broken. Jobs likes things that are broken. It means he can make something that isn't and sell it to you at a premium price. In their visionary paper, Saxe and Weitz (1982) explore two contrasting orientations by which salespeople interact with customers: sales versus customer orientation. Under the former, salespeople are driven by such notions as, "I try to sell customers all I can convince them to buy, even if I think it is more than a wise customer should buy," where the motivation is to meet one's own short-term interests and goals and not necessarily the customer's. Under the latter, salespeople are guided primarily by such ideas as, "I try to align customers who have problems with products that will help them solve their problems," where the aim is to meet mutual needs and the hope is to build long-term relationships.Sales orientation (SO) involves persuasion and "selling to" customers, whereas customer orientation (CO) is more about "interacting with" and encouraging customers to talk about their problems so that the salesperson can figure out their needs (a process akin to co-creation of solutions) and bring them in touch with solutions to their problem. Seldom has a concept sparked so much interest, resonating with both researchers and practitioners (e.g., Franke and Park 2006;Homburg et al. 2009;Leigh et al. 2001 Mark. Sci. (2012) 40:639-658 DOI 10.1007 Academics and sales managers are very interested in successfully selecting and managing salespeople, but to understand the basis for salesperson motivation and implement successful policies in this regard, they need to know the why behind CO and SO. Here is where the situation is muddled, for many anecdotal and loosely conceived explanations lack coherence and managerial relevance. Saxe and Weitz (1982) proposed that researchers should explore the psychological mechanisms underlying CO, and indeed a plethora of selling and marketing research has attempted to do just this. For example, in their meta-study, F...