Seltene Vaskulitiden als Hinweis auf Plasmozytom

Marini, Alessandra; Fenk, Roland; Plettenberg, H.; Ruzicka, Thomas; Haas, Rainer; Hengge, Ulrich R.

doi:10.1007/s00105-004-0890-5

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…In addition, the prognosis was favorable, and lesions healed after the institution of appropriate treatment: chemotherapy in 10 cases and 1 case after bone marrow transplant [ 2 , 4 , 11 , 14 – 25 ]. Two patients died before recovering, and there were no references in 9 cases [ 4 , 14 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Accelerating Healing and Relieving Pain: High-Intensity Laser Therapy for Paraneoplastic Cutaneous Vasculitis Associated with Multiple Myeloma

Felipe Fernandes Maciel,

Cordeiro,

Fernandes Batista de Amorim

et al. 2023

Am J Case Rep

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Patient: Female, 76-year-old Final Diagnosis: Multiple myeloma Symptoms: Bullous skin lesions • leg edema • leg ulcers • pain • paresthesia of extremities • purpuric pigmentations • purpuric skin lesions Clinical Procedure: Analgesia • corticosteroids • dressing • laser therapy Specialty: Dermatology • Hematology • Pathology • Surgery Objective: Unusual clinical course Background: Leukocytoclastic vasculitis (LCV) is an atypical form of cutaneous paraneoplastic manifestation. Its association with multiple myeloma (MM) is even rarer and is associated with poor prognosis and short survival, regardless of the therapy instituted. Different treatment approaches are necessary. We present a case in which LCV was the first manifestation of MM, and high-intensity laser therapy (HILT) was used as an option to accelerate healing and control pain. Case Report: A 76-year-old woman presented with pain and paresthesia in her lower limbs, associated with palpable purpura. The clinical diagnosis was small-vessel vasculitis. Laboratory tests showed an elevated gamma globulin monoclonal peak on protein electrophoresis. The immunophenotypic study of bone marrow aspirates led to the diagnosis of MM. Due to pain refractory to conventional analgesics, and the progressive evolution of the lesions, despite corticosteroid therapy, we performed photo-biomodulation with a neodymium-doped yttrium aluminum garnet laser (Nd: YAG), wavelength 1064 nanometers, using a 7-mm probe and energy density 6 J/cm 2 . After the first session, the patient was referred for pain management, and after 5 weeks, we observed complete healing in ulcerated lesions and involution of bullous lesions. Conclusions: This case report shows the positive effects of the Nd: YAG laser in modulating healing and reducing pain. HILT is an innovative, non-invasive, and effective treatment and should be considered a promising technique to accelerate healing and controlling pain.

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Section: Discussionmentioning

confidence: 99%

Accelerating Healing and Relieving Pain: High-Intensity Laser Therapy for Paraneoplastic Cutaneous Vasculitis Associated with Multiple Myeloma

Felipe Fernandes Maciel,

Cordeiro,

Fernandes Batista de Amorim

et al. 2023

Am J Case Rep

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“…[25] There have been case reports of MM which described rare presentation as LCV. [67] In fact, in a study of 2357 patients with diagnosis of MM, only eight patients were found to have LCV. [8] It indicates a sign of poor prognosis with short survival rate which happened in our case also.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous manifestations of multiple myeloma

et al. 2016

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Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. We report four such interesting patients who presented to us initially with common dermatoses such as leukocytoclastic vasculitis, pyoderma gangrenosum, and vesiculobullous disorders and were subsequently diagnosed to have MM. There were no skeletal involvements or renal function abnormality at the time of presentation. Unusual presentation, nonresponsiveness to conventional therapy, and abnormal blood parameters prompted us to suspect some underlying systemic conditions which were later confirmed to be MM after serum immunoelectrophoresis for M-band and bone marrow biopsy.

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“…This vasculitis is an inflammatory necrotizing condition of the superficial dermal vessels, and is characterized by neutrophilic, angiocentric, segmental inflammation with endothelial cell injury and fibrinoid necrosis of the blood vessel walls [9]. Clinical symptoms are variable and include palpable purpura, and hemorrhagic-necrotizing, bullous, nodular, and urticarial lesions [10]. …”

Section: Discussionmentioning

confidence: 99%

Metastatic Pulmonary Calcinosis and Leukocytoclastic Vasculitis in a Patient with Multiple Myeloma

Cagirgan¹,

Soyer²,

Vural³

et al. 2012

Turk J Hematol

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Both leukocytoclastic vasculitis and metastatic pulmonary calcification are conditions that rarely occur during the course of multiple myeloma. We present a multiple myeloma patient that had severe dyspnea due to metastatic pulmonary calcinosis, and ulceronecrotic skin lesions caused by leukocytoclastic vasculitis. After 3 courses of standarddose chemotherapy all skin and pulmonary lesions disappeared. Autologous peripheral stem cell transplantation was performed and during 1 year of follow-up the patient was in complete remission; after 1 year, laboratory test results indicated disease relapse. Although the patient was treated with bortezomib and dexamethasone, the disease progressed. Non-myeloablative allogeneic stem cell transplantation was performed, but despite of all treatment the patient died due to disease progression.Conflict of interest:None declared.

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Seltene Vaskulitiden als Hinweis auf Plasmozytom

Cited by 5 publications

References 13 publications

Accelerating Healing and Relieving Pain: High-Intensity Laser Therapy for Paraneoplastic Cutaneous Vasculitis Associated with Multiple Myeloma

Accelerating Healing and Relieving Pain: High-Intensity Laser Therapy for Paraneoplastic Cutaneous Vasculitis Associated with Multiple Myeloma

Cutaneous manifestations of multiple myeloma

Metastatic Pulmonary Calcinosis and Leukocytoclastic Vasculitis in a Patient with Multiple Myeloma

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