SEM-2/SoxC regulates multiple aspects ofC. eleganspostembryonic mesoderm development
Marissa Baccas,
Vanathi Ganesan,
Amy Leung
et al.
Abstract:Development of multicellular organisms requires well-orchestrated interplay between cell-intrinsic transcription factors and cell-cell signaling. One set of highly conserved transcription factors that plays diverse roles in development is the SoxC group.C. eleganscontains a sole SoxC protein, SEM-2. SEM-2 is essential for embryonic development, and for specifying the sex myoblast (SM) fate in the postembryonic mesoderm, the M lineage. We have identified a novel partial loss-of-functionsem-2allele that has a pr… Show more
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