Distant supervision (DS) has been widely used for relation extraction (RE), which automatically generates large-scale labeled data. However, there is a wrong labeling problem, which affects the performance of RE. Besides, the existing method suffers from the lack of useful semantic features for some positive training instances. To address the above problems, we propose a novel RE model with sentence selection and interaction representation for distantly supervised RE. First, we propose a pattern method based on the relation trigger words as a sentence selector to filter out noisy sentences to alleviate the wrong labeling problem. After clean instances are obtained, we propose the interaction representation using the word-level attention mechanism-based entity pairs to dynamically increase the weights of the words related to entity pairs, which can provide more useful semantic information for relation prediction. The proposed model outperforms the strongest baseline by 2.61 in F1-score on a widely used dataset, which proves that our model performs significantly better than the state-of-the-art RE systems.