Semantic Priming in Parkinsons Disease: Evidence for Delayed Spreading Activation

Arnott, Wendy L.; Chenery, Helen J.; Murdoch, Bruce E.; Silburn, Peter A.

doi:10.1076/jcen.23.4.502.1224

Cited by 61 publications

(65 citation statements)

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“…This result is consistent with findings of delayed lexical-semantic activation during semantic priming in some patients with PD (Angwin et al, 2005;Arnott et al, 2001;Grossman et al, 2002). Also worthy of note, Kotz, Frisch, Von Cramon, and Friederici (2003) found that patients with a basal ganglia lesion demonstrated an Table 5.…”

supporting

confidence: 78%

“…Impairments to semantic processing have also been identified in PD (Bocanegra et al, 2015;Lewis, Lapointe, Murdoch, & Chenery, 1998;Portin, Laatu, Revonsuo, & Rinne, 2000), including deficits to semantic inhibition (Arnott et al, 2010;Copland, Sefe, Ashley, Hudson, & Chenery, 2009) and alterations to automatic or controlled semantic priming (Angwin, Chenery, Copland, Murdoch, & Silburn, 2005Angwin et al, 2009;Arnott, Chenery, Murdoch, & Silburn, 2001;Arnott et al, 2011;Copland, 2003;Grossman et al, 2002). Thus, developing a better understanding of the nature and extent of semantic impairments in PD is critical to understanding language function and cognitive decline in this population.…”

Section: Introductionmentioning

confidence: 99%

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A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

Angwin

Dissanayaka

Moorcroft

et al. 2016

J Int Neuropsychol Soc

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Objectives: Cognitive-linguistic impairments in Parkinson's disease (PD) have been well documented; however, few studies have explored the neurophysiological underpinnings of semantic deficits in PD. This study investigated semantic function in PD using event-related potentials. Methods: Eighteen people with PD and 18 healthy controls performed a semantic judgement task on written word pairs that were either congruent or incongruent. Results: The mean amplitude of the N400 for new incongruent word pairs was similar for both groups, however the onset latency was delayed in the PD group. Further analysis of the data revealed that both groups demonstrated attenuation of the N400 for repeated incongruent trials, as well as attenuation of the P600 component for repeated congruent trials. Conclusions: The presence of N400 congruity and N400 repetition effects in the PD group suggests that semantic processing is generally intact, but with a slower time course as evidenced by the delayed N400. Additional research will be required to determine whether N400 and P600 repetition effects are sensitive to further cognitive decline in PD. (JINS, 2017, 23, 78-89)

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supporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

Angwin

Dissanayaka

Moorcroft

et al. 2016

J Int Neuropsychol Soc

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“…Instead, the current data add to mounting evidence that various aspects of language processing are indeed compromised in PD, including semantic priming (e.g., Arnott et al, 2001), lexical ambiguity resolution in sentences (Copland et al, 2000a(Copland et al, , 2001 and sentence processing (Grossman, 1999). The same pattern of priming for NS and PD groups is also at odds with the view that language disturbances following NS lesions are due to white matter pathway disruption causing corticocortical or thalamocortical disconnection (Alexander et al, 1987).…”

contrasting

confidence: 48%

The basal ganglia and semantic engagement: Potential insights from semantic priming in individuals with subcortical vascular lesions, Parkinson's disease, and cortical lesions

Copland

2003

J Int Neuropsychol Soc

123

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The impact of basal ganglia dysfunction on semantic processing was investigated by comparing the performance of individuals with nonthalamic subcortical (NS) vascular lesions, Parkinson's disease (PD), cortical lesions, and matched controls on a semantic priming task. Unequibiased lexical ambiguity primes were used in auditory prime-target pairs comprising 4 critical conditions; dominant related (e.g., bank-money), subordinate related (e.g., bank-river), dominant unrelated (e.g., foot-money) and subordinate unrelated (e.g., bat-river). Participants made speeded lexical decisions (word0nonword) on targets using a go-no-go response. When a short prime-target interstimulus interval (ISI) of 200 ms was employed, all groups demonstrated priming for dominant and subordinate conditions, indicating nonselective meaning facilitation and intact automatic lexical processing. Differences emerged at the long ISI (1250 ms), where control and cortical lesion participants evidenced selective facilitation of the dominant meaning, whereas NS and PD groups demonstrated a protracted period of nonselective meaning facilitation. This finding suggests a circumscribed deficit in the selective attentional engagement of the semantic network on the basis of meaning frequency, possibly implicating a disturbance of frontal-subcortical systems influencing inhibitory semantic mechanisms. (JINS, 2003(JINS, , 9, 1041(JINS, -1052

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“…This may also reveal insight into the impairments exhibited by some patient populations (Arnott et al, 2001). In order to understand these complex behaviors, one must first begin to understand how these manipulations affect brain regions associated with language processing.…”

Section: Introductionmentioning

confidence: 99%

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Tivarus¹,

Hillier²,

Schmalbrock³

et al. 2008

Brain and Language

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We describe an fMRI experiment examining the functional connectivity (FC) between regions of the brain associated with semantic and phonological processing. We wished to explore whether L-Dopa administration affects the interaction between language network components in semantic and phonological categorization tasks, as revealed by FC. We hypothesized that L-Dopa would decrease FC due to restriction of the semantic network. During two test sessions (placebo and L-Dopa) each participant performed two fMRI runs, involving phonological and semantic processing. A number of brain regions commonly activated by the two tasks were chosen: left inferior frontal, left posterior temporal and left fusiform gyri, and left parietal cortex. FC was calculated and further analyzed for effects of either the drug or task. No drug effect was found. A significant main effect for task was found, with a greater average correlation for the phonological task than for the semantic task. These findings suggest that language areas are activated in a more synchronous manner for phonological tasks than for semantic tasks. This may relate to the fact that phonological tasks are mediated to a greater extent within language areas, whereas semantic tasks likely require greater interaction outside of the language areas. Alternatively, this may be due to differences in the attentional requirements of the two tasks.

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Semantic Priming in Parkinsons Disease: Evidence for Delayed Spreading Activation

Cited by 61 publications

References 0 publications

A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

A Neurophysiological Study of Semantic Processing in Parkinson’s Disease

The basal ganglia and semantic engagement: Potential insights from semantic priming in individuals with subcortical vascular lesions, Parkinson's disease, and cortical lesions

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

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