Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis

Chapoval, Svetlana P

doi:10.1186/s13075-015-0846-4

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…However, later we and others demonstrated Plexin B1 and/or D1 expression in the immune system, particularly on DC [10,20], T cells [21] and Treg cells (our unpublished observations). As Sema4A regulates the immune response to different antigens such as allergens [19,22,23], infectious agents [14,21,24], and tissue-derived factors in autoimmunity [15,25,26,27,28], it is feasible to conclude that it plays a significant role in anti-tumor immunity that has not yet been assessed.…”

Section: Introductionmentioning

confidence: 99%

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

Iyer

Chapoval

2018

IJMS

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Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function, instructing a fine tuning of the immune response. Recent studies have shown a dysregulation of Sema4A expression in several types of cancer such as hepatocellular carcinoma, colorectal, and breast cancers. Cancers have been associated with abnormal angiogenesis. The function of Sema4A in angiogenesis and cancer is not defined. Recent studies have demonstrated Sema4A expression and function in endothelial cells. However, the results of these studies are controversial as they report either pro- or anti-angiogenic Sema4A effects depending on the experimental settings. In this mini-review, we discuss these findings as well as our data on Sema4A regulation of inflammation and angiogenesis, which both are important pathologic processes underlining tumorigenesis and tumor metastasis. Understanding the role of Sema4A in those processes may guide the development of improved therapeutic treatments for cancer.

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Section: Introductionmentioning

confidence: 99%

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

Iyer

Chapoval

2018

IJMS

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“…Patients with highly active RA (DAS28 > 5.1) and patients with low activity (DAS28 score < 3.2) showed elevated class 4 semaphorin levels. SEMA4A might be involved in RA activity [64]. Elevated SEMA4A levels are directly correlated with DAS28 and DAS28-CRP, markers of the swollen joint count [23,28].…”

Section: Class 4 Semaphorins and Ramentioning

confidence: 99%

The Role of Semaphorins in the Pathogenesis of Rheumatoid Arthritis

Rosik,

Kulpa,

Szczepanik

et al. 2024

Cells

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Rheumatoid arthritis (RA) is one of the most common autoimmune diseases. Inflammation of the synovial fluid propagates the pathological process of angiogenesis. Semaphorins play a crucial role in the context of endothelial cell function, and their pleiotropic nature has various effects on the further development of RA. This narrative review summarises the various roles of semaphorins in the pathology of RA and whether they could play a role in developing novel RA treatment options.

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“…As Sema4A regulates the immune response to different antigens such as allergens (19,22,23), infectious agents (14,21,24), and tissue-derived factors in autoimmunity (15,(25)(26)(27)(28), it is feasible to conclude that it plays a significant role in anti-tumor immunity, what have not been assessed as yet.…”

Section: Introductionmentioning

confidence: 99%

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation

Iyer¹,

Chapoval²

2018

Preprint

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Neuroimmune semaphorin 4A (Sema4A), a member of semaphorin family of transmembrane and secreted proteins, is an important regulator of neuronal and immune functions. In the nervous system, Sema4A primarily regulates the functional activity of neurons serving as an axon guidance molecule. In the immune system, Sema4A regulates immune cell activation and function granting a fine tuning of immune response. Recent studies have shown a dysregulation of Sema4A expression in several types of cancer such as hepatocellular carcinoma, colorectal and breast cancers. Cancers have been associated with abnormal angiogenesis. The function of Sema4A in angiogenesis and cancer is not defined. Recent studies have demonstrated Sema4A expression and function in endothelial cells. However, the results of these studies are controversial as they report either pro – or anti-angiogenic Sema4A effects depending on the experimental settings. In this mini-review, we discuss these findings as well as our data on Sema4A regulation of inflammation and angiogenesis, which both are important pathologic processes underlining tumorigenesis and tumor metastasis. Understanding the role of Sema4A in those processes may guide the development of improved therapeutic treatments for cancer.

show abstract

Semaphorin 4A as novel regulator and promising therapeutic target in rheumatoid arthritis

Cited by 5 publications

References 10 publications

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation: A Promoter or a Suppressor?

The Role of Semaphorins in the Pathogenesis of Rheumatoid Arthritis

Neuroimmune Semaphorin 4A in Cancer Angiogenesis and Inflammation

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