Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development

Szczurkowska, Joanna; Guo, Alan; Martin, Jacqueline; Lee, Seong-il; Martinez, Edward; Chien, Chia Te; Khan, Tamor A.; Singh, Ravnit; Dadson, Doreen; Tran, Tracy S.; Pautot, Sophie; Shelly, Maya

doi:10.1016/j.celrep.2022.110483

Cited by 3 publications

(2 citation statements)

References 56 publications

(116 reference statements)

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“…The associations within the complex are not only necessary for semaphorin3A-mediated cGMP increases in dendrites and CA1 apical dendrite development, but also for bipolar polarity establishment in CA1 pyramidal progenitors. Together, these findings demonstrate that apical dendrite development is promoted by the extrinsic Sema3A/PlexinA3 cue and mediated by a localized cGMP-synthesizing complex (Szczurkowska et al 2022 ).…”

Section: Meeting Highlightsmentioning

confidence: 79%

The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report

Friebe

Kraehling

Russwurm

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Increasing cGMP is a unique therapeutic principle, and drugs inhibiting cGMP-degrading enzymes or stimulating cGMP production are approved for the treatment of various diseases such as erectile dysfunction, coronary artery disease, pulmonary hypertension, chronic heart failure, irritable bowel syndrome, or achondroplasia. In addition, cGMP-increasing therapies are preclinically profiled or in clinical development for quite a broad set of additional indications, e.g., neurodegenerative diseases or different forms of dementias, bone formation disorders, underlining the pivotal role of cGMP signaling pathways. The fundamental understanding of the signaling mediated by nitric oxide-sensitive (soluble) guanylyl cyclase and membrane-associated receptor (particulate) guanylyl cyclase at the molecular and cellular levels, as well as in vivo, especially in disease models, is a key prerequisite to fully exploit treatment opportunities and potential risks that could be associated with an excessive increase in cGMP. Furthermore, human genetic data and the clinical effects of cGMP-increasing drugs allow back-translation into basic research to further learn about signaling and treatment opportunities. The biannual international cGMP conference, launched nearly 20 years ago, brings all these aspects together as an established and important forum for all topics from basic science to clinical research and pivotal clinical trials. This review summarizes the contributions to the “10th cGMP Conference on cGMP Generators, Effectors and Therapeutic Implications,” which was held in Augsburg in 2022 but will also provide an overview of recent key achievements and activities in the field of cGMP research.

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Section: Meeting Highlightsmentioning

confidence: 79%

The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report

Friebe

Kraehling

Russwurm

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Reduced-rank regression analysis using morphological features supported the separation of major types (cross-validated R 2 = 0.24 and correlations 0.87, 0.61, and 0.72, respectively) and revealed a select set of genes well predicting morphological diversity (Figure 7B). Notably, some selected genes were directly related to morphological properties, such as Sema3a, a gene involved in the growth of apical dendrite of cortical neurons (Polleux et al, 2000;Szczurkowska et al, 2022) and Epha6, a gene involved in the regulation of spine morphology (Das et al, 2016). The Sema3a expression may be responsible for the unusually large dendrite trees of D-stellate cells among CN cell types.…”

Section: Transcriptional Programs Underlie Functional Specialization ...mentioning

confidence: 99%

Molecular logic for cellular specializations that initiate the auditory parallel processing pathways

Jing

Ngodup

et al. 2023

Preprint

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SummaryThe cochlear nucleus (CN), the starting point for all auditory processing in the brain, comprises a suite of well-defined cell types that are morphologically and biophysically specialized for initiating parallel processing pathways, yet their molecular distinctions are largely unknown. To determine how their functional specialization is determined at the molecular level, we employed a single-nucleus RNA sequencing analysis of the mouse CN to transcriptomically define its cell types and then related each molecularly distinct cell type to well-established cell type via Patch-seq, an approach linking single-cell transcriptome to their morphological/electrophysiological features. We reveal a one-to-one correspondence between an expanded set of molecular cell types and all previously described major types. Our approach also yields a set of novel markers for these cell types, as well as clear molecular subtypes for several major principal cell types. This study thus establishes the CN as a brain region with clearly defined cell types from the molecular to the circuit level, opening a new window for genetic dissection of auditory processing and hearing disorders.

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Directed mechanisms for apical dendrite development during neuronal polarization

Khan

Guo

Martin

et al. 2022

Developmental Biology

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Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development

Cited by 3 publications

References 56 publications

The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report

The 10th International Conference on cGMP 2022: recent trends in cGMP research and development—meeting report

Molecular logic for cellular specializations that initiate the auditory parallel processing pathways

Directed mechanisms for apical dendrite development during neuronal polarization

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