Semaphorins and neuropilins expression in salivary gland tumors

Fonseca, Felipe Paiva; Bingle, Lynne; Santos‐Silva, Alan Roger; Lopes, Márcio Ajudarte; Almeida, Oslei Paes de; Andrade, Bruno Augusto Benevenuto De; Mariano, Fernanda Viviane; Kowalski, Luiz Paulo; Rangel, Ana Lúcia Carrinho Ayroza; Martins, Manoela Domingues; Meurer, Luíse; Speight, Paul M.; Vargas, Pablo Agustı́n

doi:10.1111/jop.12341

Cited by 11 publications

(10 citation statements)

References 39 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FGF‐2 immunostaining and FGFR‐1 immunostaining were digitally assessed on a quantitative scale by the use of aperio positive pixel count v9 software. The immunostaining scores for tumour cells and stromal cells of each case were calculated by use of the formula [tumour score = (percentage weak × 1) + (percentage moderate × 2) + (percentage strong × 3)], and ranged from 100 to 300, in agreement with previous studies from our group …”

Section: Methodssupporting

confidence: 81%

FGF‐2 and FGFR‐1 might be independent prognostic factors in oral tongue squamous cell carcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Methodssupporting

confidence: 81%

FGF‐2 and FGFR‐1 might be independent prognostic factors in oral tongue squamous cell carcinoma

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Therefore, the changes in the level of SEMA3B in the vascular endothelium of tumor biopsies found in this work indicate that with the increase of endometrial cancer grade and cell de-differentiation, the processes of neovascularization are intensified [31–35]. Moreover, considering the pro-apoptotic role of the analyzed protein in the context of tumor angiogenesis, it is possible that there is a reduction in the percentage of normal vascular endothelial cells in endometrial cancer, with the simultaneous promotion of cell proliferation with accumulated mutations [4,5].…”

Section: Discussionmentioning

confidence: 99%

“…Semaphorin 3B (SEMA3B) is a tumor growth suppressor. The biological activity of SEMA3B results from its interaction with neuropilin receptors (NRP1 and NRP2), which leads to reduced secretion of vascular endothelial growth factor and inhibition of formation of new blood vessel networks through which nutrients and oxygen are supplied to the tumor mass [4,5]. The abnormal expression pattern of SEMA3B has been reported in breast cancer [4], ovarian cancer [6], hepatocellular carcinoma [7], lung cancer [8], and endometrial cancer [9].…”

Section: Introductionmentioning

confidence: 99%

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Dziobek

Opławski²,

Grabarek

et al. 2019

Med Sci Monit

View full text Add to dashboard Cite

Background SEMA3B is known as an inhibitor of angiogenesis and cell proliferation. During carcinogenesis, the loss of SEMA3B function is observed, which results in the progression of neoplastic changes. The aim of this study was to evaluate the expression profile of SEMA3B in endometrial cancer (G1–G3) in comparison to the control group and to assess whether the observed changes in expression could become a molecular marker in endometrial cancer. Material/Methods The study group consisted of 45 patients diagnosed with endometrial cancer (G1, 17; G2, 15; G3, 13). The control group included 15 patients. SEMA3B expression was assessed using the immunohistochemical method. Statistical analysis was carried out using the Statistica 12 PL program (StatSoft, USA). It included the Kruskal-Wallis test and post hoc Dunn’s test (p<0.05). Results Statistically significant differences in the level of SEMA3B expression were observed between all analyzed groups. The expression pattern of SEMA3B was as follows: cancer cells G1>G2>G3; endothelial cells: G3>G1>G2; stromal cells: G2>G1>G3. Conclusions Analysis of the SEMA3B expression profile shows the complexity of neoplastic transformation, which confirms the different expression of SEMA3B in endometrial cancer cells and endothelial cells. The present results and data in the literature data suggest that SEMA3B expression indicates the progression of carcinogenesis in the context of endometrial cancer.

show abstract

“…All slides were scanned into high-resolution images with Aperio Scanscope CS Slide Scanner (Aperio Technologies Inc., Vista, California, USA). In order to calculate the scores of positivity expression of p-Akt1, digital analyses were performed, as previously described [41, 55]. Nuclear p-Akt1 expression was scored based on the percentage [%] of positive nuclei, assessed digitally with the Nuclear Algorithm (Aperio Technologies Inc.).…”

Section: Methodsmentioning

confidence: 99%

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas

Soares

Morais

Carlos³

et al. 2018

Oncotarget

View full text Add to dashboard Cite

Melanomas are highly aggressive tumours derived from melanocytes, which occur most commonly in the skin. Occasionally, these tumours may appear in oral and sinonasal mucous membranes. In this study, we performed a comparative analysis of the Phosphorylated Akt1 (p-Akt1) expression in 144 patients affected by cutaneous (CM), 34 oral cavity (OM), and 31 sinonasal melanomas (SNM). Similar to the metastatic cutaneous melanomas, p-Akt1 was overexpressed in 17/34 of the oral cavity and 20/31 of the sinonasal melanomas. In addition, the p-Akt1-nuclear expression was associated with poorer cancer-specific survival in cutaneous (P < .0001), oral (P < .0001), and sinonasal (P = .001) melanomas. Multivariate analysis showed p-Akt1 to be an independent prognostic marker in oral (P = .041) and sinonasal (P < .0001) melanomas patients. In conclusion, p-Akt1 overexpression is an independent prognostic marker in mucosal melanomas and is significantly up-regulated in sinonasal melanomas. As both mucosal and metastatic cutaneous melanomas showed high frequency of p-Akt1 expression, these findings suggest that mucosal melanomas have a biological behaviour, similar to the aggressive cutaneous melanomas.

show abstract

Semaphorins and neuropilins expression in salivary gland tumors

Abstract: Sema3A, Sema3B, Np-1, and Np-2 may be involved in the pathogenesis of SGT, but their expression did not present a statistically significant prognostic potential in this study.

Cited by 11 publications

References 39 publications

FGF‐2 and FGFR‐1 might be independent prognostic factors in oral tongue squamous cell carcinoma

FGF‐2 and FGFR‐1 might be independent prognostic factors in oral tongue squamous cell carcinoma

Expression of Semaphorin 3B (SEMA3B) in Various Grades of Endometrial Cancer

Phosphorylated Akt1 expression is associated with poor prognosis in cutaneous, oral and sinonasal melanomas

Contact Info

Product

Resources

About