Semeiology of the Gammaglobulinic Pattern of Cerebrospinal Fluid in Children

Gerbaut, L; Ponsot, G

doi:10.1016/b978-0-08-031739-7.50050-1

Cited by 1 publication

(6 citation statements)

References 6 publications

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“…The total protein concentration was normal in aII these cases. The proportion of gammaglobulins was elevated in three of the first patients to be studied (I, 7, 13); protein profile studies performed as previously described by Gerbaut et al (11) were normal in four patients (8,9, I I, 14) and showed a local secretion ofIgG in three patients (3,5,6).…”

Section: Laboratory Findingsmentioning

confidence: 72%

“…Magnetic resonance imaging was performed in 6 patients (I, 2, 11, 16, 17, 18) and revealed abnormalities in each case: they consisted of high T2 signal intensity in periventricular regions of the white matter. CT scan did not show any plaques in two of these patients (11,18).…”

Section: Laboratory Findingsmentioning

confidence: 80%

“…Computed tomographic scans were performed in 13 patients. They were normal in four patients (11,17,18,19) and abnormal in 9 patients. Abnormalities observed during an attack consisted of areas of low density in four cases (2,4,7,8), areas of contrast enhancement in five cases (2,3,14,15,16), and enlargement of CSF spaces in four cases (3,12,14,15).…”

Section: Laboratory Findingsmentioning

confidence: 87%

“…Fever, headache, photophobia, nausea, vomiting and nuchal rigidity, aII symptoms suggestive of an inflammation of the meninges were the mode of onset in four patients (10,11,13,18) and necessitated rapid admission. Within hours or days these four patients developed signs of myelopathy.…”

Section: Clinical Onset Of the Diseasementioning

confidence: 99%

“…Leukocyte counts and analysis of sedimentation rates were performed in 12 patients and were elevated in six cases (2,9,11,12,13,18).…”

Section: Laboratory Findingsmentioning

confidence: 99%

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Multiple Sclerosis in Children: Report of Clinical and Paraclinical Features of 19 Cases

et al. 1988

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We report our experience concerning clinical and paraclinical features of multiple sclerosis in 19 children. The disease was highly variable in its presentation but acute episodes of retrobulbar optic neuritis or transverse myelitis or cerebellitis were commonly observed at the onset. Diagnosis was very often suspected as soon as the first episode when there was clinical evidence of more than one lesion (43%) or study of the cerebrospinal fluid demonstrated a local secretion of immunoglobulins (60%). Evoked potential studies and nuclear magnetic resonance imaging were performed during the course of the disease and exhibited abnormalities of the kind observed in adult patients and with a similar frequency; this suggests that such studies can be very useful in the evaluation of children suspected of having multiple sclerosis. When the initial form of the disease was a chronic myelopathy, the course was progressive from the onset, leading rapidly to a marked invalidity (15%). Most often a succession of relapses and remissions occurred after the first attack and major sequelae appeared 5 to 10 years later. Such features are not very different from those observed in adult patients and suggest that these patients can benefit from the progress resulting from therapeutic trials in adult patients.

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Section: Laboratory Findingsmentioning

confidence: 72%

Section: Laboratory Findingsmentioning

confidence: 80%