Semen characteristics as a function of age in 833 fertile men

Schwartz, D.; Mayaux, Marie-Jeanne; Spira, Alfred; Moscato, M. L.; Jouannet, Pierre; Czyglik, F; David, G

doi:10.1016/s0015-0282(16)46946-3

Cited by 188 publications

(118 citation statements)

References 8 publications

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“…Abstinence adjusted studies do not provide a uniform picture. A significant age-dependent decrease [2,25] as well as constant values over the age range [19] or even a non significant age dependent increase with age [26] have been detected in healthy men. In infertile patient's sperm concentration remains unalterated [22] or increases [21,23,[26][27][28][29].…”

Section: Discussionmentioning

confidence: 97%

“…Classical parameters of spermiograms did not change significantly in over 800 fertile men between 21 and 50 years of age. Unfortunately, elderly men were not included in that particular study [19]. However Levitas et al detected a statistically significant and inverse relationship between semen volume, sperm quality, and patient age, but the patients had a longer period of sexual abstinence before the testing [20].…”

Section: Discussionmentioning

confidence: 99%

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The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Brahem

Mehdi

Elghezal

et al. 2011

J Assist Reprod Genet

110

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Purpose To investigate the effects of male aging on semen quality, DNA fragmentation and chromosomal abnormalities in the spermatozoa of infertile patients and fertile men. Methods Semen samples of 140 infertile patients (24-76 years) and 50 men with proven fertility (25-65 years) were analyzed according to WHO guidelines. DNA fragmentation was detected by TUNEL assay, while aneuploidy was assessed by FISH. Results In the patient group, semen volume and vitality of spermatozoa decreased significantly with age, while sperm concentration showed a statistically significant increase with age. DNA fragmentation as well as disomy of sex chromosomes and disomy 8 did not show a statistically significant change with age. However, the diploidy rate was significantly increased with patient's age. In the control group, conventional semen parameters as well as DNA fragmentation and chromosomal abnormalities did not show a statistically significant with age. Conclusion Increased age in infertile men is associated with an increase in sperm concentration and diploidy, as well as a decline in semen volume and sperm vitality. However motility, morphology and DNA fragmentation are not affected by male age.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

Brahem

Mehdi

Elghezal

et al. 2011

J Assist Reprod Genet

110

View full text Add to dashboard Cite

show abstract

“…In contrast to these findings, one study 17 examined 833 fertile men and found lower volumes in the younger (21-25 years) and older (46-50 years) cohorts compared with those of middle age (26-45 years). Several other studies did not find any differences among men of different ages in their semen volume, 18,19 while one reported an increase in volume with age.…”

Section: Effect Of Paternal Age On Semen Qualitymentioning

confidence: 88%

The effects of advanced paternal age on fertility

Kovac¹,

Addai²,

Smith³

et al. 2013

Asian J Androl

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Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life.

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“…Changes in semen quality can occur from the effects of age [4], which is associated with diminished semen volume, sperm motility or sperm morphology [5][6]. Most studies are based on volunteers, sperm donors and infertility clinic groups.…”

Section: Introductionmentioning

confidence: 99%

Male age influences oocyte-donor program results

Girsh

Katz

Genkin

et al. 2008

J Assist Reprod Genet

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Background The purpose of our research was to examine the relationship between male age and semen parameters in a range of ages (from 20s to 60s) in Egg Donation Program (EDP) cycles. EDP provides a pool of high quality oocytes, thus allowing better analysis of the sperm efficacy. Discussion The retrospective study population consisted of 484 male partners of patients undergoing EDP in in-vitro fertilization (IVF) treatments. A comparison was made of male age and sperm parameters within two groups: cycles resulting in a pregnancy (pregnant group) and cycles which failed to achieve a pregnancy (non-pregnant group). The men involved in the pregnant group were found to be significantly younger 43.2±8.1 than those of the nonpregnant group 46.8±7.8 (p=0.003). Analysis of sperm morphology revealed a significant prevalence of teratozoospermia in males of the non-pregnant group, as compared to the males of the pregnant group (29% vs. 11%, respectively). The results also demonstrate that sperm parameters are apparently not diminished until men reach the age of 40. However, between 40-50 years old semen parameters deteriorate. Male age was found to be related to a reduction in sperm strict criteria: 44.8 in normozoospermia, 47.9 (p=0.02), 48.4 (p=0.04) and 51.9 (p=0.001) years old in mild teratozoospermia, moderate teratozoospermia and severe teratozoospermia, respectively. Additionally, the results showed that the percentage of "healthy" embryos on day 3 of embryo culture was lower in the non-pregnant group (26%), as compared with the pregnant group (34%; p=0.01). Conclusion Our study confirms that sperm parameters are reduced by age and suggests that this age-dependent effect could be a reason for failures in IVF cycles even in EDP couples.

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Semen characteristics as a function of age in 833 fertile men

Cited by 188 publications

References 8 publications

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population

The effects of advanced paternal age on fertility

Male age influences oocyte-donor program results

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