Semen-mediated Enhancement of HIV Infection Markedly Impairs the Antiviral Efficacy of Microbicides

ZirafiOnofrio,; KimKyeong-Ae,; RoanNadia, R; MayerBenjamin,; KlugeSilvia,; JiangShibo,; GreeneWarner, C; KirchhoffFrank,; MünchJan,

doi:10.1089/aid.2014.5390.abstract

Cited by 1 publication

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References 157 publications

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“…Similarly, semenogellin-derived amyloid fibrils in semen are also capable of enhancing virus attachment and entry 45 . The potential importance of a SEVI-like activity is also demonstrated by infectivity studies in cell culture-based assays, in which the inclusion of semen reduced the activity of several antivirals in blocking infectivity (with maraviroc — an antiretroviral agent developed to prevent HIV-1 infection by blocking the C–C chemokine receptor type 5 (CCR5) co-receptor 46 — being a notable exception) 47 . Although semen-derived amyloid fibrils enhance infection in vitro , less is known about their effects in vivo .…”

Section: Transmission Bottlenecks In the Donormentioning

confidence: 99%

Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

et al. 2015

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HIV-1 infection typically results from the transmission of a single viral variant, the transmitted/founder (T/F) virus. Studies of these HIV-1 variants provide critical information about the transmission bottlenecks and the selective pressures acting on the virus in the transmission fluid and in the recipient tissues. These studies reveal that T/F virus phenotypes are shaped by stochastic and selective forces that restrict transmission and may be targets for prevention strategies. In this Review, we highlight how studies of T/F viruses contribute to a better understanding of the biology of HIV-1 transmission and discuss how these findings affect HIV-1 prevention strategies.

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Section: Transmission Bottlenecks In the Donormentioning

confidence: 99%