Semen Parameters as Determinants of Success in 1662 Cycles of Intrauterine Insemination After Controlled Ovarian Hyperstimulation

Sakhel, Khaled; Abozaid, T.; Schwark, S.; Ashraf, M.; Abuzeid, Mostafa I.

doi:10.1016/j.fertnstert.2005.07.644

Cited by 15 publications

(16 citation statements)

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“…In contrast, Sakhel et al (27) described an increase in the pregnancy rate from 17.1% to 30.4% if the mobility exceeded 20% (P¼.06). In our study, only initial (d-type) immotility proved to be a significantly predictive parameter: the pregnancy rate per couple decreased from 40.9% to 19.3% if 70% of the spermatozoa were immobile.…”

Section: Indications For Treatment: Male Factor Infertilitymentioning

confidence: 94%

“…In contrast, if we combine oligospermia (<20 million/mL) and asthenospermia (mobility at <25%), the rate of clinical pregnancy per couple decreases from 37.6% to 13.4% (P<.05). With respect to the sperm count, Sakhel et al (27) obtained (for 1662 IUI cycles) a pregnancy rate per cycle of 30.3% with more than 5 million spermatozoa/mL versus 18.8% with less than 5 million (P¼.10). Belaisch-Allart et al (18) obtains a pregnancy rate per cycle of 12.5% with less than 10 million spermatozoa/mL and of 17% with more than 20 million.…”

Section: Indications For Treatment: Male Factor Infertilitymentioning

confidence: 99%

See 1 more Smart Citation

Predictive factors for pregnancy after intrauterine insemination (IUI): An analysis of 1038 cycles and a review of the literature

Merviel

Heraud

Grenier

et al. 2010

Fertility and Sterility

257

196

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Section: Indications For Treatment: Male Factor Infertilitymentioning

confidence: 94%

Section: Indications For Treatment: Male Factor Infertilitymentioning

confidence: 99%

Predictive factors for pregnancy after intrauterine insemination (IUI): An analysis of 1038 cycles and a review of the literature

Merviel

Heraud

Grenier

et al. 2010

Fertility and Sterility

257

196

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“…23 Wainer, et al showed that a minimum of 5 x 10 6 motile spermatozoa should be inseminated when the normal morphology of the sperm after preparation is < 30%. 24 Study by Miller, et al have demonstrated that the total motile sperm count independently predicts success of IUI and that cycles with less than 10 million total motile sperm are significantly less likely to result in a pregnancy.…”

Section: Post Wash Sperm Countmentioning

confidence: 99%

Factors affecting success of intrauterine insemination: a 3 year prospective study

Jayakrishnan¹,

Abraham²,

Nambiar³

2016

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONIntrauterine insemination (IUI) is the therapeutic process of placing washed spermatozoa transcervically into the uterine cavity for the treatment of infertility. IUI theoretically allows a relatively higher number of motile spermatozoa to reach the oocyte and it has been used for a variety of indications such as non-severe male factor infertility, unexplained infertility, cervical mucus hostility, ovulatory disturbances, mild endometriosis, antisperm antibodies and male sexual dysfunctions like impotency, hypospadias, and retrograde ejaculation. [1][2][3][4] The rationale behind IUI is increasing the gamete density at the time and site of potential fertilization i.e., increasing the chances of spermatozoa meeting the oocyte in the fallopian tube after ovulation has occurred. IUI is generally considered as an intermediate step of low to moderate complexity before the application of more sophisticated assisted reproductive technologies (ART) such as IVF with or without ICSI.The overall success rates of IUI remains controversial and depends on several factors, with published pregnancy rates varying from as low as 5% to as high as 70% per patient, however a 10%-20% clinical pregnancies per cycle is an acceptable range for all aetiologies.2 The pregnancy rates per IUI cycle are quite variable in the literature due to differences in cause and duration of infertility, type of ovarian stimulation, sperm preparation techniques, treatment cycles and number of times IUI is performed during a cycle (single or double). Results:The overall pregnancy rate was 15.2%. Among the predictive factors evaluated, the infertility diagnosis (PCO and male factor, p value <0.001), the post wash semen count (5-10 million, p value <0.001), type of IUI (double IUI over single IUI, p value <0.001) and the endometrial thickness on the day of trigger (9-10mm, χ2 =551.59 df =5 p<0.001) significantly influenced the pregnancy rate. Conclusions: IUI is a successful contemporary treatment for appropriately selected cases of PCO and male factor infertility, especially when female age is <35 years.

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“…Studies try to elucidate which standard semen parameters impact more on pregnancy rates for couples undergoing IUI, and it seems that sperm motility is the most predictive [6][7][8]. It must be remembered that Total Motile Sperm Count [TMSC] inseminated has been cited as the most predictive index of conception after IUI cycles [9][10][11].…”

Section: Influence Of Semen Qualitymentioning

confidence: 99%

“…It must be remembered that Total Motile Sperm Count [TMSC] inseminated has been cited as the most predictive index of conception after IUI cycles [9][10][11]. A minimalTMSC of 1 million for insemination was initially reported to be a requirement for pregnancy after insemination [12], but the systematic review of the literature by Ombelet et al in 2014 indeed confirms that the native sperm TMSC which shows the best correlation with IUI success is in the range of 5-10 million [6,[13][14][15][16]. According to a previous study, sperm concentration above 10 million is not related to further improvement in conception rates [12], while other investigators have reported the best pregnancy rates when more than 10 million motile spermatozoa are inseminated [9,17].…”

Section: Influence Of Semen Qualitymentioning

confidence: 99%

How to Perform the Best Intrauterine Insemination? A Review

Carranza¹,

Santamaría²

2015

Andrology (Los Angel)

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Intrauterine insemination is a treatment used in couples with mild/moderate male factor, when female partner has at least one tube patent. Numerous studies have attempted to determine for many years which parameters are limiting to ensure pregnancy with this technique of assisted reproduction. This review focuses on prognostic factors for a successful outcome, as semen quality, female etiology, synchronization with ovulation, assessment of follicle rupture, number of inseminations per cycle and influence of uterine contractions. We conclude with this review that intrauterine insemination is a less invasive and expensive option than others [IVF], with acceptable results when adequately indicated. We conclude with this review that intrauterine insemination can be performed when patient is less than 40 years old and there are at least 5 million of motile sperm to be inseminated. The abstinence interval of 3 days prior to produce the sperm sample is the optimal period and either one or two inseminations are valid, ideally performed in the frame time between 12 and 38 hours after ovulation induction. Also, follicle rupture and uterine contractions observed by ultrasound scan following intrauterine inseminations are favorable prognostic factors.

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Semen Parameters as Determinants of Success in 1662 Cycles of Intrauterine Insemination After Controlled Ovarian Hyperstimulation

Cited by 15 publications

References 0 publications

Predictive factors for pregnancy after intrauterine insemination (IUI): An analysis of 1038 cycles and a review of the literature

Predictive factors for pregnancy after intrauterine insemination (IUI): An analysis of 1038 cycles and a review of the literature

Factors affecting success of intrauterine insemination: a 3 year prospective study

How to Perform the Best Intrauterine Insemination? A Review

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